Patents by Inventor Yongping Xie

Yongping Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR FGF RECEPTOR KINASES INHIBITORS
    Publication number: 20090312321
    Abstract: Described are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent disease or disordered associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activity of kinases such as Abl, ALK, AMPK, Aurora, Axl, Bcr-Abl, BIK, Bmx, BRK, BTK, c-Kit, CSK, cSrc, CDK1, CHK2, CK1, CK2, CaMKII, CaMKIV, DYRK2, EGFR, EphB1, FES, FGFR1, FGFR2, FGFR3, Flt1, Flt3, FMS, Fyn, GSK3?, IGF-1R, IKK?, IKK?, IR, IRAK4, ITK, JAK2, JAK3, JNK1?1, JNK2?, KDR, Lck, LYN, MAPK1, MAPKAP-K2, MEK1, MET, MKK4, MKK6, MST2, NEK2, NLK, p70S6K, PAK2, PDGFR, PDGFR?, PDK1, Pim-2, Plk3, PKA, PKB?, PKC?, PKCtheta, PKD2, c-Raf, RET, ROCK-I, ROCK-II, Ron, Ros, Rsk1, SAPK2a, SAPK2b, SAPK3, SAPK4, SGK, SIK, Syk, Tie2, TrkB, WNK3, and ZAP-70.
    Type: Application
    Filed: April 6, 2007
    Publication date: December 17, 2009
    Applicant: IRM LLC
    Inventors: Pingda Ren, Guobao Zhang, Shuli You, Taebo Sim, Nathanael S. Gray, Yongping Xie, Xing Wang, Yun He
  • Immunosuppressant compounds and compositions
    Patent number: 7572811
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: August 11, 2009
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Wenqi Gao, Nathanael Schiander Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
    Publication number: 20090192203
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: November 7, 2006
    Publication date: July 30, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher Cow, Mihai Azimioara, Ross Russo, Yongping Xie, Xing Wang
  • COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
    Publication number: 20090137591
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Application
    Filed: February 3, 2006
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Christopher Cow, Robert Epple, Xing Wang, Yongping Xie, Hans Martin Seidel
  • Compounds and Compositions as Protein Kinase Inhibitors
    Publication number: 20080300246
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKK?, IKK?, JNK2? 2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFR?, PKA, PKB?, PKD2, Rsk1, SAPK2?, SAPK2?, SAPK3, SGK, Tie2 and TrkB kinases.
    Type: Application
    Filed: August 9, 2006
    Publication date: December 4, 2008
    Applicant: IRM LLC
    Inventors: Yongping Xie, Guobao Zhang, Xing Wang, Nathanael S. Gray, Yi Liu
  • Compounds and Compositions as Ppar Modulators
    Publication number: 20080292608
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: November 7, 2006
    Publication date: November 27, 2008
    Applicant: IRM LLC
    Inventors: Robert Epple, Yongping Xie, Xing Wang, Ross Russo, Christopher Cow, Mihai Azimioara
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 7449582
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, CSK, JNK1, JNK2, PDGF-R, p38, p70S6K, TGF?, SRC, EGFR, c-Kit, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6 and SAPK2? kinases.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: November 11, 2008
    Assignee: IRM LLC
    Inventors: Qiang Ding, Yongping Xie, Nathanael S. Gray, Shuli You, Greg Chopiuk, Jiqing Jiang, Yi Liu, Ruo Steensma, Xing Wang, Taebo Sim
  • Compounds And Compositions As Ppar Modulators
    Publication number: 20080114044
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Application
    Filed: May 12, 2005
    Publication date: May 15, 2008
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara, Yongping Xie
  • Compounds and Compositions as Ppar Modulators
    Publication number: 20070244130
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Application
    Filed: May 24, 2005
    Publication date: October 18, 2007
    Applicant: IRM LLC
    Inventors: Robert Epple, Yongping Xie, Xing Wang, Christopher Cow, Ross Russo
  • Immunosuppressant Compounds and Compositions
    Publication number: 20070203100
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: February 24, 2005
    Publication date: August 30, 2007
    Applicant: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Gao Wenqi, Nathanael Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • Compounds And Compositions As Ppar Modulators
    Publication number: 20070203155
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Application
    Filed: May 24, 2005
    Publication date: August 30, 2007
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher Cow, Yongping Xie, Xing Wang, Ross Russo, Mihai Azimioara, Enrique Saez
  • Compounds and compositions as protein kinase inhibitors
    Publication number: 20050187230
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, CSK, JNK1, JNK2, PDGF-R, p38, p70S6K, TGF?, SRC, EGFR, c-Kit, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6 and SAPK2? kinases.
    Type: Application
    Filed: October 8, 2004
    Publication date: August 25, 2005
    Applicant: IRM LLC
    Inventors: Qiang Ding, Yongping Xie, Nathanael Gray, Shuli You, Greg Chopiuk, Jiqing Jiang, Yi Liu, Ruo Steensma, Xing Wang, Taebo Sim
  • Methods and compounds for inhibiting MRP1
    Patent number: 6743794
    Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: June 1, 2004
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Jeffrey Daniel Cohen, Joseph Michael Gruber, Douglas Webb Johnson, Louis Nickolaus Jungheim, Julian Stanley Kroin, Peter Ambrose Lander, Ho-Shen Lin, Mark Christopher Lohman, Brian Stephen Muehl, Bryan Hurst Norman, Vinod Francis Patel, Michael Enrico Richett, Kenneth Jeff Thrasher, Sreenivasarao Vepachedu, Wesley Todd White, Yongping Xie, Jeremy Schulenburg York, Brandon Lee Parkhurst, Qiupang Wang
  • Compounds and methods for inhibiting MRP1
    Publication number: 20040077675
    Abstract: The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
    Type: Application
    Filed: October 3, 2003
    Publication date: April 22, 2004
    Inventors: Rosanne Bonjouklian, Douglas Webb Johnson, Peter Ambrose Lander, Mark Christopher Lohman, Vinod Francis Patel, Screenivasara Vepachedu, Yongping Xie
  • Compounds and method for inhibiting MRP1
    Patent number: 6670373
    Abstract: The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: December 30, 2003
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Douglas Webb Johnson, Peter Ambrose Lander, Mark Christopher Lohman, Vinod Francis Patel, Sreenivasarao Vepachedu, Yongping Xie
  • Indolocarbazole anticancer agents and methods of using them
    Patent number: 6605596
    Abstract: The present invention relates to anti-tumor compounds, compositions and methods.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: August 12, 2003
    Assignee: Advanced Life Sciences, Inc.
    Inventors: David E. Zembower, Yongping Xie, Yasheen Zhou
  • Methods and compounds for inhibiting mrp1
    Publication number: 20030100576
    Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
    Type: Application
    Filed: May 21, 2002
    Publication date: May 29, 2003
    Inventors: Rosanne Bonjouklian, Jeffrey Daniel Cohen, Joseph Michael Gruber, Douglas Webb Johnson, Louis Nickolaus Jungheim, Julian Stanley Kroin, Peter Ambrose Lander, Ho-Shen Lin, Mark Christopher Lohman, Brian Stephen Muehl, Bryan Hurst Norman, Vinod Francis Patel, Michael Enrico Richett, Kenneth Jeff Thrasher, Sreenivasarao Vepachedu, Wesley Todd White, Yongping Xie, Jeremy Schulenburg York, Brandon Lee Parkhurst
  • Indolocarbazole anticancer agents and methods of using them
    Publication number: 20030087842
    Abstract: The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity.
    Type: Application
    Filed: October 29, 2001
    Publication date: May 8, 2003
    Applicant: Advanced Life Sciences, Inc.
    Inventors: David E. Zembower, Yongping Xie, Yasheen Zhou