Patents by Inventor Yongqiang Zhu

Yongqiang Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10982242
    Abstract: The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: April 20, 2021
    Assignees: SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD., ZHEJIANG UNIVERSITY, ZHEJIANG NHU COMPANY LTD.
    Inventors: Hongwei Yu, Yong Lv, Yong Li, Jianbo Chen, Shaofeng Chen, Weifeng Li, Hongmei Zhang, Yongqiang Zhu
  • Publication number: 20210053971
    Abstract: Disclosed in the present invention are a crystal form of monomethanesulfonate of a deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound as represented by formula I, and a preparation method therefor. The crystal form is highly stable, can be used for treatment or prevention of diseases or conditions by means of epidermal growth factor receptors (EGFRs) in some mutation forms, can effectively inhibit the growth of a variety of tumor cells, and have an inhibiting effect on other proteases of EGFR and Her families, and thus can be used for preparing antitumor drugs.
    Type: Application
    Filed: March 15, 2019
    Publication date: February 25, 2021
    Applicant: NANJING CAREPHAR SHENGHUI PHARMACEUTICAL CO., LTD.
    Inventors: Yongqiang ZHU, Yang YANG, Ou HAI, Zhaogang LIU, Chao FENG
  • Patent number: 10774350
    Abstract: The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be ?50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: September 15, 2020
    Assignees: ZHEJIANG NHU COMPANY LTD., ZHEJIANG UNIVERSITY, HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD., SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD.
    Inventors: Shenfeng Yuan, Hongwei Yu, Zhaofeng Chen, Yongqiang Zhu, Yi Min, Yong Li, Baishan Hu, Guisheng Qiu, Kai Yu
  • Patent number: 10728297
    Abstract: Embodiments of the present invention provide a streaming media play mode determination method and apparatus. The method includes: acquiring a streaming media play status in a current play mode, where the current play mode corresponds to a set of parameters for reflecting software and hardware states corresponding to a current play environment; calculating a candidate play mode according to the current play mode, if the streaming media play status satisfies a preset condition; and judging whether the current play mode is the same as the candidate play mode, and determining a play mode for streaming media to be played according to a result of the judgment. The embodiments of the present application provide a mechanism for intelligently selecting the streaming media play mode, make it possible to intelligently calculate the matching degrees of various types of algorithms in the current environment, enabling a best play mode to be preferentially selected.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: July 28, 2020
    Assignee: Chengdu Changtian Information Technology Co., Ltd.
    Inventor: Yongqiang Zhu
  • Patent number: 10654851
    Abstract: A type of deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof. The derivatives are compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds or salts thereof can be used for treatment or prevention of diseases or illnesses through certain mutant forms of epidermal growth factor receptors, inhibit the growth of various tumor cells effectively, and inhibit other proteases of EGFR and Her families, they can be used for preparing anti-tumor drugs.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: May 19, 2020
    Assignee: NANJING CHUANGTE PHARMACEUTICAL TECHNOLOGY CO., LTD.
    Inventors: Yongqiang Zhu, Zhaogang Liu, Chao Feng, Shihe Hu, Hao Chen, Enhe Bai, Jie Wang, Jingmiao Shi
  • Publication number: 20190225610
    Abstract: A type of deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof. The derivatives are compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds or salts thereof can be used for treatment or prevention of diseases or illnesses through certain mutant forms of epidermal growth factor receptors, inhibit the growth of various tumor cells effectively, and inhibit other proteases of EGFR and Her families, they can be used for preparing anti-tumor drugs.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 25, 2019
    Inventors: Yongqiang ZHU, Zhaogang LIU, Chao FENG, Shihe HU, Hao CHEN, Enhe BAI, Jie WANG, Jingmiao SHI
  • Publication number: 20190194704
    Abstract: The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be ?50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient.
    Type: Application
    Filed: June 25, 2018
    Publication date: June 27, 2019
    Inventors: Shenfeng YUAN, Hongwei YU, Zhaofeng CHEN, Yongqiang ZHU, Yi MIN, Yong LI, Baishan HU, Guisheng QIU, Kai YU
  • Publication number: 20180288121
    Abstract: Embodiments of the present invention provide a streaming media play mode determination method and apparatus. The method includes: acquiring a streaming media play status in a current play mode, where the current play mode corresponds to a set of parameters for reflecting software and hardware states corresponding to a current play environment; calculating a candidate play mode according to the current play mode, if the streaming media play status satisfies a preset condition; and judging whether the current play mode is the same as the candidate play mode, and determining a play mode for streaming media to be played according to a result of the judgment. The embodiments of the present application provide a mechanism for intelligently selecting the streaming media play mode, make it possible to intelligently calculate the matching degrees of various types of algorithms in the current environment, enabling a best play mode to be preferentially selected.
    Type: Application
    Filed: September 27, 2017
    Publication date: October 4, 2018
    Applicant: Chengdu Changtian Information Technology Co., Ltd.
    Inventor: Yongqiang Zhu
  • Publication number: 20180245113
    Abstract: The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
    Type: Application
    Filed: October 21, 2016
    Publication date: August 30, 2018
    Inventors: HONGWEI YU, YONG LV, YONG LI, JIANBO CHEN, ZHAOFENG CHEN, WEIFENG LI, HONGMEI ZHANG, YONGQIANG ZHU
  • Patent number: 9421237
    Abstract: The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: August 23, 2016
    Assignee: PEKING UNIVERSITY
    Inventors: Runtao Li, Jingrong Cui, Yongqiang Zhu, Shuyang Yao, Zemei Ge, Tieming Cheng
  • Publication number: 20120135921
    Abstract: The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma.
    Type: Application
    Filed: May 17, 2010
    Publication date: May 31, 2012
    Inventors: Runtao Li, Jingrong Cui, Yongqiang Zhu, Shuyang Yao, Zemei Ge, Tieming Cheng