Abstract: The present application belongs to the technical field of proteolysis-targeting chimeras (PROTACs), and discloses a PROTAC molecule and a preparation method and use thereof. A ligand for a target protein in the PROTAC molecule of the present application is a pyridine carboxylic acid-1-oxide derivative. In cell and zebrafish experiments, the PROTAC molecule exhibits no toxic and side effects at a drug concentration allowing a desired effect. At a cellular level, an inhibition level of the PROTAC molecule for human tyrosinase (TYR) reaches less than or equal to 1 ?mol/L. The PROTAC molecule in the present application can significantly reduce the generation of melanin by degrading TYR, and has excellent solubility, safety, and efficacy and a low effective concentration.

Abstract: The present invention relates to an electronic cigarette set, in particular to an ultrasonic atomizer, comprising an e-liquid guide assembly. In an embodiment, the e-liquid guide assembly comprises an e-liquid guide ceramic, e-liquid guide cotton, and springs located between the e-liquid guide ceramic and the e-liquid guide cotton and abut the e-liquid guide cotton against an atomization piece. Embodiments of the present invention use a combination of an e-liquid guide ceramic and e-liquid guide cotton to guide an e-liquid. Further details are disclosed herein.

Abstract: A shipping assembly is described. The assembly includes a shipping container, a bottom structure, and a top structure. The bottom and top structures retain objects in a spaced-apart arrangement within the shipping container. A paperboard sheet is folded into three horizontal layers to form the bottom structure. A first layer has apertures to retain the objects. A second layer is below and spaced apart from the first layer with a substantially flat surface below the first apertures. A third layer is below and spaced apart from the second layer. Another paperboard sheet is folded into two horizontal layers to form the top structure. A fourth layer has another set of apertures to retain the objects. A fifth layer is above and spaced apart from the fourth layer. The apertures are align to position the objects in the shipping container.

Abstract: An atomizer for an electronic cigarette is provided. The atomizer comprises a liquid cartridge device with a liquid outlet, atomization cotton, and an ultrasonic atomization piece. The middle of the atomization cotton abuts against a central area of the ultrasonic atomization piece by means of a spring to form an atomization zone. An end portion of the atomization cotton is pressed against the bottom of the liquid cartridge device and covers the liquid outlet. An atomization cavity is provided between the ultrasonic atomization piece and the bottom of the liquid cartridge device. An atomization cavity gas inlet and an atomization cavity gas outlet are provided at the top of the atomization cavity. The atomization cavity gas inlet (501) and the liquid outlet (321) are staggered.

Abstract: Disclosed is an electronic cigarette atomizer including a liquid cartridge (6) and an ultrasonic atomization piece (42) mounted vertically. The liquid cartridge (6) is located above the ultrasonic atomization piece (42), a liquid guide channel (311) communicated with the liquid cartridge (6) is disposed below the liquid cartridge (6), a liquid outlet (331) is horizontally disposed in the liquid guide channel (311), and the caliber of the liquid outlet (331) is smaller than that of the liquid guide channel (311); and liquid guide cotton (43) is horizontally mounted across the ultrasonic atomization piece (42). The liquid guide cotton (43) is in contact with or attached to an atomization surface of the ultrasonic atomization piece (42), and the liquid outlet (331) abuts against the liquid guide cotton (43). With the electronic cigarette atomizer, when smoking, e-liquid is supplied in time, and e-liquid supply and ultrasonic atomization are balanced, such that the burning phenomenon can be prevented.

Abstract: An electronic cigarette atomizing core and an atomizer are disclosed. The electronic cigarette atomizing core includes an outer sleeve and an inner sleeve, wherein the outer sleeve is provided with a liquid passing port. An atomization cavity is provided between the bottom of the inner sleeve and the ultrasonic atomization piece. A liquid guide cotton in communication with the liquid passing port is sandwiched between the outer sleeve and the inner sleeve. The inner sleeve is longitudinally provided with a main air groove and an auxiliary air groove at intervals. The cross sectional area of the auxiliary air groove is ¼ to ? the size of the cross sectional area of the main air groove. The main air groove is in communication with the atomization cavity. An auxiliary air inlet, an auxiliary air channel, the auxiliary air groove, and the atomization cavity are in communication with each other.

Abstract: An electronic cigarette atomizer and an electronic cigarette are disclosed. The electronic cigarette atomizer comprises an air inlet (1), an air inlet passage (2), an atomization cavity (3), an air outlet passage (4), an air outlet (5), and a suction nozzle (6) communicated sequentially, and further comprises an adjustment mechanism (7) for adjusting the air output of the air outlet. The adjustment mechanism (7) simultaneously adjusts the air input of the air inlet (1) and the air output of the air outlet (5). The electronic cigarette atomizer can adjust the air output of the air outlet (5) of the atomizer and can meet the needs of users with different lung capacities for different smoke concentration adjustment modes. The electronic cigarette atomizer can simultaneously adjust the air flow at the air inlet (1) and the air outlet (5) of the atomizer.

Abstract: An atomizing sheet assembly, an atomizer, and an electronic cigarette are disclosed. The atomizing sheet assembly comprises an e-liquid guide member, an atomizing sheet, and an atomizing seat. The atomizing sheet is fixed on the atomizing seat. The e-liquid guide member is in contact with an atomizing surface of the atomizing sheet. The atomizing seat is made of an elastic material. The e-liquid guide member is flaky. The atomizing seat is provided with a through hole. The flaky e-liquid guide member passes through the through hole and is in contact with the atomizing sheet. The atomizing sheet assembly can effectively adjust the e-liquid guide rate.

Abstract: Disclosed are an electronic cigarette atomization core (4) and atomizer. The electronic cigarette atomization core (4) includes an ultrasonic atomization piece (46) disposed horizontally, a liquid guide cotton (45) disposed above the ultrasonic atomization piece (46), and an electrode plate (47) placed on the liquid guide cotton (45). Each end of the electrode plate (47) is provided with a curved segment (472). The curved segment (472) includes a first contact (4721) located above a second contact (4722), wherein the first contact (4721) and the second contact (4722) are electrically connected but are distant horizontally, and the second contact (4722) abuts against an atomization surface electrode of the ultrasonic atomization piece (46) to form an electrical connection.

Abstract: Methods, systems, and apparatus, including a reusable recyclable packing pouch. The reusable recyclable packing pouch includes a plastic container and a paperboard jacket. The plastic container includes a first portion and a second portion. The first portion has a shaped region. The second portion is coupled to the first portion by a hinge, and sized to mate with the first portion such as to define a space between facing surfaces of the second portion and the shaped region of the first portion When the first portion and the second portion are coupled, the plastic container includes a flange extending annularly around the shaped region. The paperboard jacket has an aperture defined therethrough. The aperture is sized to permit the shaped region of the plastic container to pass through while the flange extends past edges of aperture and overlaps with a region of paperboard jacket at a periphery of the aperture.

Abstract: An ultrasonic atomization core (17), an ultrasonic atomizer, and an ultrasonic electronic cigarette are disclosed. The ultrasonic atomization core (17) comprises an atomization sleeve (1). The atomization sleeve is provided with an ultrasonic atomization sheet (2) and e-liquid guide cotton (3) that communicates the outside with an atomization surface of the ultrasonic atomization sheet (2). The atomization surface of the ultrasonic atomization sheet (2) is a concave surface. The e-liquid guide cotton (3) has a convex surface corresponding to the atomization surface. The curvature of the convex surface of the e-liquid guide cotton (3) is greater than or equal to the curvature of the atomization surface of the ultrasonic atomization sheet (2). The convex surface of the e-liquid guide cotton (3) is in contact with the atomization surface of the ultrasonic atomization sheet (2).

Abstract: An ultrasonic electronic cigarette atomizer and an electronic cigarette, wherein the ultrasonic electronic cigarette atomizer comprises a shell, a tobacco tar storage bottle, an ultrasonic atomization piece and a flaky tobacco tar storage body fit to one side face of the ultrasonic atomization piece are provided in the shell, and a tobacco tar guide body is fixed to an outer wall of at least one side of the tobacco tar storage bottle; one side face of the tobacco tar guide body is communicated with the inner cavity of the tobacco tar storage bottle, and the other side face of the tobacco tar guide body is contacted with the side face of the tobacco tar storage body which is away from the ultrasonic atomization piece; and the ultrasonic atomization piece and the tobacco tar storage body are provided to be parallel to the length direction of an electronic cigarette.

Abstract: An ultrasonic atomization sheet (1) and atomizer and an ultrasonic electronic cigarette are disclosed. The ultrasonic atomization sheet (1) comprises a flaky piezoelectric substrate (101), a surface electrode (102) attached to one surface of the piezoelectric substrate (101), and a drive electrode (103) attached to the other surface of the piezoelectric substrate (101). The piezoelectric substrate (101) is elongated. The piezoelectric substrate (101) is composed of an oscillating section (106) and a fixed section (107) connected to each other. The surface electrode (102) is fixed on one surface of the oscillating section (106), and the drive electrode (103) is fixed on the other surface of the oscillating section (106). The surface electrode (102) and the drive electrode (103) are both rectangular or circular.

Abstract: An electronic cigarette atomizer and an electronic cigarette are disclosed. The electronic cigarette atomizer comprises an air inlet (1), an air inlet passage (2), an atomization cavity (3), an air outlet passage (4), an air outlet (5), and a suction nozzle (6) that are communicated in sequence. The electronic cigarette atomizer further comprises a housing (8) and an adjustment mechanism (7) for adjusting the air input of the air inlet (1). The air inlet passage (2), the atomization cavity (3), and the air outlet passage (4) are all arranged in the housing (8), and a top of the housing (8) is provided with a top cover (9). The adjustment mechanism (7) comprises a movable member (10) located in the top cover (9) and movable axially along the top cover (9).

Abstract: An electronic cigarette atomization core and atomizer is disclosed. The electronic cigarette atomization core includes an atomization member (3), an outer sleeve (24), a connection sleeve (22), and atomization cotton (14). A lower segment of the connection sleeve (22) is sleeved outside an upper segment of the outer sleeve (24). The outer sleeve (24) is sleeved outside the atomization cotton (14). The outer sleeve (24) is provided with a first e-liquid passage hole (2401) capable of communicating an inner cavity of an electronic cigarette e-liquid bin (12) with the atomization cotton (14). The connection sleeve (22) is axially movable or circumferentially rotatable relative to the outer sleeve (24) to close or open the first e-liquid passage hole (2401). A buffer sealing structure is arranged between the connection sleeve (22) and the outer sleeve (24).

Abstract: The present application provides a double-beam laser polishing device and a double-beam laser polishing method for an aluminum alloy, which includes a frame; a rotary workbench and an optical path system, which are arranged on the frame. The optical path system includes: a first fiber laser, a second fiber laser, a first three-dimensional galvanometer, and a second three-dimensional galvanometer. The first three-dimensional galvanometer is connected with the first fiber laser through an optical fiber, and the second three-dimensional galvanometer is connected with the second fiber laser through an optical fiber. The first three-dimensional galvanometer and the second three-dimensional galvanometer are arranged side by side above the rotary workbench in a horizontal direction.

Abstract: A shipping assembly is described. The assembly includes a shipping container, a bottom structure, and a top structure. The bottom and top structures retain objects in a spaced-apart arrangement within the shipping container. A paperboard sheet is folded into three horizontal layers to form the bottom structure. A first layer has apertures to retain the objects. A second layer is below and spaced apart from the first layer with a substantially flat surface below the first apertures. A third layer is below and spaced apart from the second layer. Another paperboard sheet is folded into two horizontal layers to form the top structure. A fourth layer has another set of apertures to retain the objects. A fifth layer is above and spaced apart from the fourth layer. The apertures are align to position the objects in the shipping container.

Abstract: The present application provides a double-beam laser polishing device and a double-beam laser polishing method for an aluminum alloy, which includes a frame; a rotary workbench and an optical path system, which are arranged on the frame. The optical path system includes: a first fiber laser, a second fiber laser, a first three-dimensional galvanometer, and a second three-dimensional galvanometer. The first three-dimensional galvanometer is connected with the first fiber laser through an optical fiber, and the second three-dimensional galvanometer is connected with the second fiber laser through an optical fiber. The first three-dimensional galvanometer and the second three-dimensional galvanometer are arranged side by side above the rotary workbench in a horizontal direction.

Abstract: A shipping assembly is described. The assembly includes a shipping container, a bottom structure, and a top structure. The bottom and top structures retain objects in a spaced-apart arrangement within the shipping container. A paperboard sheet is folded into three horizontal layers to form the bottom structure. A first layer has apertures to retain the objects. A second layer is below and spaced apart from the first layer with a substantially flat surface below the first apertures. A third layer is below and spaced apart from the second layer. Another paperboard sheet is folded into two horizontal layers to form the top structure. A fourth layer has another set of apertures to retain the objects. A fifth layer is above and spaced apart from the fourth layer. The apertures are align to position the objects in the shipping container.

Abstract: Disclosed is an atomizer, comprising an atomizer body, a suction nozzle assembly mounted at the top of the atomizer body, an air inlet provided in the atomizer body, an atomizing sheet and a tobacco tar cavity provided in the atomizer body, and a tobacco tar guide body which guides tobacco tar in the tobacco tar cavity to an atomizing surface of the atomizing sheet. The atomizer introduces entered air to allow all the air to pass over, at a low level, the surface where the atomizing cotton is in contact with the atomizing sheet. The atomizing efficiency is higher, and more smoke is produced.