Abstract: In an embodiment, the present disclosure pertains to a method of treating or preventing C. difficile infections. In some embodiments, the method includes administering an antitoxin to a subject in need thereof. In some embodiments, the antitoxin includes a designed ankyrin repeat protein (DARPin). In an additional embodiments, the present disclosure pertains to a composition including an antitoxin for treating or preventing C. difficile infections. In some embodiments, the anti-toxin includes a DARPin. In some embodiments, the anti-toxin is a monomeric or dimeric DARPin for the neutralization of Clostridium difficile toxin B (TcdB).

Abstract: Novel, antibody-based binding agents derived from camelid VHH and human immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include humanized VHH peptide monomers, linked groups of humanized VHH peptide monomers, humanized VHH peptide monomers joined to antibody Fc domains, and humanized VHH peptide monomers joined to IgG antibodies.

Abstract: An extension lead with a conductive piece in a first socket of the extension lead is provided separately from a conductive part connected to a power cord connection piece. A rotating part for driving the conductive piece or the conductive part to move to and contact with the other of the conductive piece or the conductive part is further provided. When a male tab of the plug is inserted into the first socket, the male tab pushes the rotating part to rotate, and drives the conductive piece or the conductive part to move to and contact with the other of the conductive piece or the conductive part, and the circuit is turned on at this time. When the male tab is pulled out from the first socket, the conductive piece and the conductive part return to their original positions, and the conductive piece is not charged at this time.

Abstract: An extension lead with a conductive piece in a first socket of the extension lead is provided separately from a conductive part connected to a power cord connection piece. A rotating part for driving the conductive piece or the conductive part to move to and contact with the other of the conductive piece or the conductive part is further provided. When a male tab of the plug is inserted into the first socket, the male tab pushes the rotating part to rotate, and drives the conductive piece or the conductive part to move to and contact with the other of the conductive piece or the conductive part, and the circuit is turned on at this time. When the male tab is pulled out from the first socket, the conductive piece and the conductive part return to their original positions, and the conductive piece is not charged at this time.