Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, CY, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A transformable robot comprises an arm structure, a leg structure and a head of the robot which are fixed to a ribcage structure. The arm structure includes a left arm and a right arm; the leg structure includes a left leg and a right leg; the ribcage structure includes a first steering gear fixed on an upper part of a second fixing frame; a rotating output shaft of the first steering gear successively passes through a top wall of the second fixing frame and a first backing plate to fixedly connected to a first steering wheel fixed on a first rotating frame; the first steering wheel is provided with an arc-shaped limited opening; a limited column on the first backing plate is movably passed through the limited opening; the rotating output shaft of the first steering gear rotates to drive the first rotating frame to rotate.