Abstract: The present invention provides an anti-CD47 antibody or antigen-binding fragment thereof, a preparation method therefor and the use for treating or preventing CD47-related diseases.

Abstract: The present disclosure relates to the field of mineral processing and separation, and in particular, to an underground coal hypergravity field separation system and a separation process. The separation system includes a grading hydrocyclone group, hypergravity field separators, feeding pumps, and conveying pumps. Coal collected underground is graded through a grading hydrocyclone first, then is fed into the hypergravity field separators for separation, and finally, is conveyed to a next link for dehydration through the conveying pumps. The separation system of the present disclosure has less supporting equipment, small floor area, and no complex pipeline, and is suitable for a downhole operation. In addition, the hypergravity field separators can provide a high-strength centrifugal acceleration, which can realize rapid separation of coal gangue particles in a radial direction and a tangential direction, and realize effective separation of fine coal gangue particles.

Abstract: An intelligent control method for a dry dense medium fluidized bed separator includes supplying air to fluidize a bed; estimating an initial bed density according to a washability curve of a raw coal; detecting a magnetic material content in the bed to obtain a real-time bed density, and adjusting the real-time bed density according to a result from an analysis on a deviation from the initial bed density; during separation, adjusting a medium addition amount and a scraper discharge speed to maintain a stability of a bed height; separating the raw coal in the dry dense medium fluidized bed separator to obtain a clean coal product; and detecting a product ash content of the clean coal product, comparing the product ash content with a target ash content, and if a difference between the product ash content and the target ash content exceeds an expectation, adjusting the initial bed density.

Abstract: Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).

Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Abstract: Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).

Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.

Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Abstract: Substituted quinazoline compounds of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and X are defined herein. It also discloses a pharmaceutical composition containing one of these compounds.

Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.

Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5,T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Abstract: Dihydrobenzoquinone compounds of the following formula: wherein R1, R2, R3, and R4 are defined herein. Also disclosed is a method of treating cancer with one of the dihydrobenzoquinone compounds.