Patents by Inventor Yongxin Zhao

Yongxin Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF
    Publication number: 20200215206
    Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
    Type: Application
    Filed: February 4, 2016
    Publication date: July 9, 2020
    Applicants: SUZHOU M-CONJ BIOTECH CO., LTD., HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Linyao Zhao, Hangbo Ye, Huihui Guo, Qianqian Tong, Minjun Cao, Junxiang Jia, Chengyu Yang, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Chen Lin, Zhixiang Guo, Zhicang Ye
  • Charged linkers and their uses for conjugation
    Patent number: 10696700
    Abstract: Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 30, 2020
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Xing Li, Yuangyuang Huang, Qingliang Yang
  • Charged linkers and their uses for conjugation
    Patent number: 10696699
    Abstract: Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 30, 2020
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Xing Li, Yuangyuang Huang, Qingliang Yang
  • Charged linkers and their uses for conjugation
    Patent number: 10683314
    Abstract: Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 16, 2020
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Xing Li, Yuangyuang Huang, Qingliang Yang
  • CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS
    Publication number: 20200172480
    Abstract: A conjugate of a potent cytotoxic agent with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
    Type: Application
    Filed: February 5, 2020
    Publication date: June 4, 2020
    Applicant: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: R. Yongxin ZHAO, Yue ZHANG, Yourang MA
  • CROSS-LINKERS AND THEIR USES
    Publication number: 20200148764
    Abstract: Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.
    Type: Application
    Filed: October 14, 2019
    Publication date: May 14, 2020
    Inventors: Ravi V.J. Chari, Robert Yongxin Zhao, Yelena Kovtun, Rajeeva Singh, Wayne C. Widdison
  • METHODS FOR THE ACYLATION OF MAYTANSINOL
    Publication number: 20200153130
    Abstract: Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.
    Type: Application
    Filed: September 18, 2019
    Publication date: May 14, 2020
    Inventors: Wayne C. Widdison, Robert Yongxin Zhao
  • Hydrophilic linkers and ligand-drug conjugates thereof
    Patent number: 10646585
    Abstract: Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 12, 2020
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Sanxing Sun, Robert Yongxin Zhao, Xing Li, Huihui Guo, Junxiang Jia, Hongsheng Xie, Xiaomai Zhou, Yuanyuan Huang, Qingliang Yang, Xiaotao Zhuo, Hangbo Ye, Shun Gai, Lan Qu, Wenjun Li, Chen Lin
  • OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL
    Publication number: 20200123218
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 23, 2020
    Applicants: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam Ezra Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Methods for Examining Podocyte Foot Processes in Human Renal Samples Using Conventional Optical Microscopy
    Publication number: 20200081005
    Abstract: The invention provides a method for preparing an expanded renal (kidney) tissue sample suitable for microscopic analysis. Expanding the kidney sample can be achieved by binding, e.g., anchoring, key biomolecules to a polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network, isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, kidney sample.
    Type: Application
    Filed: August 15, 2019
    Publication date: March 12, 2020
    Inventors: Edward Stuart Boyden, Andrew Hanno Beck, Yongxin Zhao, Octavian Bucur
  • DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE
    Publication number: 20200079820
    Abstract: The present invention is related to novel cytotoxic agents, derivatives of Amanita toxins of Formula (I), wherein , - - - , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, L, m, n and Q are defined herein, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
    Type: Application
    Filed: April 20, 2016
    Publication date: March 12, 2020
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Qianqian TONG, Minjun CAO, Linyao ZHAO, Junxiang JIA, Wenjun LI, Xiaotao ZUO, Chen LIN, Yifang XU, Zixiang GUO
  • CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE
    Publication number: 20200069814
    Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
    Type: Application
    Filed: April 6, 2017
    Publication date: March 5, 2020
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
  • Methods for Diagnosing Neoplastic Lesions
    Publication number: 20200041514
    Abstract: A method for diagnosing cancer in an expanded biological tissue sample of a patient comprising providing at least one sample image of the expanded biological tissue sample; providing a computer configured to analyze the sample; analyzing, with the computer, the sample detect and segment nuclei; calculating, with the computer, molecular characteristics of those nuclei; and determining, with the computer, a diagnosis of cancer of the sample by comparing the sample with a benign normal tissue reference.
    Type: Application
    Filed: August 15, 2019
    Publication date: February 6, 2020
    Inventors: Edward Stuart Boyden, Andrew Hanno Beck, Yongxin Zhao, Octavian Bucur, Humayun Irshad
  • Conjugates of cell binding molecules with cytotoxic agents
    Patent number: 10501412
    Abstract: A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a formula (I), wherein T, L, m, n, Y, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: December 10, 2019
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: R. Yongxin Zhao, Yue Zhang, Yourang Ma
  • CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS
    Publication number: 20190367453
    Abstract: A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R1, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
    Type: Application
    Filed: August 13, 2019
    Publication date: December 5, 2019
    Applicant: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: R. Yongxin ZHAO, Yue ZHANG, Yourang MA
  • Cross-linkers and their uses
    Patent number: 10494431
    Abstract: Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: December 3, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Ravi V. J. Chari, Robert Yongxin Zhao, Yelena Kovtun, Rajeeva Singh, Wayne C. Widdison
  • Charged linkers and their uses for conjugation
    Patent number: 10464955
    Abstract: Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: November 5, 2019
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Xing Li, Yuangyuang Huang, Qingliang Yang
  • CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS
    Publication number: 20190330149
    Abstract: A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
    Type: Application
    Filed: May 9, 2019
    Publication date: October 31, 2019
    Applicant: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: R. Yongxin ZHAO, Yue ZHANG, Yourang MA
  • Methods for the acylation of maytansinol
    Patent number: 10461449
    Abstract: Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: October 29, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Wayne C. Widdison, Robert Yongxin Zhao
  • Hydrophilic linkers and ligand-drug conjugates thereof
    Patent number: 10456479
    Abstract: Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: October 29, 2019
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Sanxing Sun, Robert Yongxin Zhao, Xing Li, Huihui Guo, Junxiang Jia, Hongsheng Xie, Xiaomai Zhou, Yuanyuan Huang, Qingliang Yang, Xiaotao Zhuo, Hangbo Ye, Shun Gai, Lan Qu, Wenjun Li, Chen Lin