Patents by Inventor Yongxing Qiu

Yongxing Qiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11534994
    Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: December 27, 2022
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
  • Publication number: 20220372391
    Abstract: The present invention generally relates to a method for applying a coating of hydrophilic polymers onto polyvinylalcohol-based hydrogel contact lenses to improve lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a polyvinylalcohol-based hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant polyvinylalcohol-based hydrogel contact lens has a coating with improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rinsing.
    Type: Application
    Filed: April 20, 2022
    Publication date: November 24, 2022
    Inventors: Chung-Yuan Chiang, Yongxing Qiu
  • Patent number: 11459479
    Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: October 4, 2022
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, Chung-Yuan Chiang, Newton T. Samuel, Richard Govan, Ciara Dauenhauer
  • Publication number: 20220299796
    Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort.
    Type: Application
    Filed: June 7, 2022
    Publication date: September 22, 2022
    Inventors: Yongxing Qiu, John Dallas Pruitt, Kelly Kayi Tallau, Angela Driver-Scott, Chung-Yuan Chiang
  • Publication number: 20220281190
    Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 8, 2022
    Inventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
  • Patent number: 11407734
    Abstract: Provided is a preparation method for a tyrosine kinase inhibitor and an intermediate thereof. Specifically, a preparation method for a cyanoquinoline compound is provided. The method has a high yield, good product purity, and mild reaction conditions.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: August 9, 2022
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Guobing Feng, Yongxing Cao, Peng Zhang, Zhenjun Qiu, Long Zhang
  • Patent number: 11385478
    Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: July 12, 2022
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, John Dallas Pruitt, Kelly Kayi Tallau, Angela Driver-Scott, Chung-Yuan Chiang
  • Patent number: 11364695
    Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: June 21, 2022
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
  • Publication number: 20220137263
    Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.
    Type: Application
    Filed: January 11, 2022
    Publication date: May 5, 2022
    Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Robert Carey Tucker, Yuan Chang, Ethan Leveillee
  • Patent number: 11256003
    Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: February 22, 2022
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Robert Carey Tucker, Yuan Chang, Ethan Leveillee
  • Publication number: 20220032564
    Abstract: The invention is related to a coated contact lens, especially a coated silicone hydrogel contact lens, which comprises an anterior surface, an opposite posterior surface, and a layered structural configuration from the anterior surface to the posterior surface. The layered structural configuration comprises an outer anterior surface hydrogel layer, an inner layer, and an outer posterior surface hydrogel layer. The inner layer is a lens bulk material. The coated contact lens has a superior lens surface softness and a good lens surface hydrophilicity while optionally having a desirably-lower polyquaternium-1 uptake.
    Type: Application
    Filed: July 27, 2021
    Publication date: February 3, 2022
    Inventors: Yongxing Qiu, John Dallas Pruitt, Ciara Dauenhauer, Chung-Yuan Chiang, Paul William Oyler, Robert Carey Tucker
  • Patent number: 11099300
    Abstract: The invention is generally related to a method for producing, in a consistent manner, SiHy contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, the base coating is formed by having two solution coating steps separated by at least one rinsing step with a buffered saline or pH controlled solution. The durability of the hydrogel coatings on resultant silicone hydrogel contact lenses can be improved significantly and will not vary with the optical power (i.e., the center thickness) of the SiHy contact lens under coating.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 24, 2021
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, Hyeju Kim, Ciara Dauenhauer
  • Patent number: 11029447
    Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 8, 2021
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Angela Driver-Scott, Ciara Dauenhauer, Rita Anand
  • Patent number: 11029446
    Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 8, 2021
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel
  • Publication number: 20210132411
    Abstract: The invention is related to a contact lens, especially a SiHy contact lens, which comprises a lens bulk material covered with an outer surface hydrogel layer thereon and has a posterior surface and an opposite anterior surface. The outer surface hydrogel layer consists of an anterior outer hydrogel layer and a posterior outer hydrogel layer. A contact lens of the invention is characterized by having a difference in surface softness between its posterior (BC) and anterior (FC) surfaces.
    Type: Application
    Filed: November 3, 2020
    Publication date: May 6, 2021
    Inventors: Yongxing Qiu, Robert Carey Tucker, Yeming Gu
  • Publication number: 20210130648
    Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
  • Patent number: 10920102
    Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: February 16, 2021
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
  • Patent number: 10830923
    Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: November 10, 2020
    Assignee: Alcon Inc.
    Inventors: Yongxing Qiu, Kasey Jon Minick, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Kelly Kayi Tallau, Matthew McCollum, Richard Govan
  • Publication number: 20200339836
    Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
    Type: Application
    Filed: July 9, 2020
    Publication date: October 29, 2020
    Inventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
  • Publication number: 20200324314
    Abstract: The invention is generally related to a method for producing, in a consistent manner, contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material having azetidinium groups onto a base coating of a polyanionic polymer on a contact lens at a relatively low temperature (e.g., from about 40° C. to about 60° C.). The coating temperature for forming a durable hydrogel coating on top of the base coating of a contact lens can be significantly lowered by raising, in situ, the pH (to about 9.5 or higher) of a reactive coating solution which contains the hydrophilic polymeric material having azetidinium groups.
    Type: Application
    Filed: April 9, 2020
    Publication date: October 15, 2020
    Inventors: Newton T. Samuel, Yongxing Qiu, John Dallas Pruitt, Matthew McCollum