Patents by Inventor Yongyan Nie

Yongyan Nie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11573223
    Abstract: A reagent for extracting immunosuppressant drugs from a whole blood sample for immunoassay includes protein denaturant, proteolytic enzyme, surfactant and pH buffer. A method and an immunoassay kit for detection of the immunosuppressant concentration in a whole blood sample uses the extraction reagent. The extraction reagent doesn't need the use of organic solvent as that in the traditional extraction methods, therefore the adverse effects of the organic solvent on the antibody activity in a detection system and the other relative defects associated to its use are obviated. The drug extraction process doesn't need centrifugation, as the processed sample can be directly applied for immunoassay. The operation for drug extraction is simple, and the detection result based on this extraction method is accurate.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: February 7, 2023
    Assignee: Shanghai Inzex Biotechnology Co., Ltd.
    Inventors: Fengbo Wu, Yongyan Nie, Xiaojuan Shi
  • Publication number: 20200232975
    Abstract: The disclosure provides a reagent for extracting immunosuppressant drugs from whole blood sample for immunoassay. The extraction reagent comprises protein denaturant, proteolytic enzyme, surfactant and pH buffer. The disclosure also provides a method and an immunoassay kit for detection of the immunosuppressant concentration in a whole blood sample using the extraction reagent. The extraction reagent of the present disclosure doesn't need the use of organic solvent as that in the traditional extraction method, therefore the adverse effects of the organic solvent on the antibody activity in a detection system and the other relative defects associated to its use are obviated. The drug extraction process of the present disclosure doesn't need centrifugation, the processed sample can be directly applied for immunoassay. The operation for drug extraction by the present disclosure is simple, and the detection result based on this extraction method is accurate.
    Type: Application
    Filed: April 2, 2020
    Publication date: July 23, 2020
    Inventors: Fengbo Wu, Yongyan Nie, Xiaojuan Shi
  • Publication number: 20180024124
    Abstract: The disclosure provides a reagent for extracting immunosuppressant drugs from whole blood sample for immunoassay. The extraction reagent comprises protein denaturant, proteolytic enzyme, surfactant and pH buffer. The disclosure also provides a method and an immunoassay kit for detection of the immunosuppressant concentration in a whole blood sample using the extraction reagent. The extraction reagent of the present disclosure doesn't need the use of organic solvent as that in the traditional extraction method, therefore the adverse effects of the organic solvent on the antibody activity in a detection system and the other relative defects associated to its use are obviated. The drug extraction process of the present disclosure doesn't need centrifugation, the processed sample can be directly applied for immunoassay. The operation for drug extraction by the present disclosure is simple, and the detection result based on this extraction method is accurate.
    Type: Application
    Filed: May 29, 2015
    Publication date: January 25, 2018
    Inventors: Fengbo Wu, Yongyan Nie, Xiaojuan Shi