Patents by Inventor Yongzhong Du

Yongzhong Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pegylated and fatty acid grafted chitosan oligosaccharide, synthesis method and application for drug delivery system
    Patent number: 8466127
    Abstract: The present invention provides a PEGylated and fatty acid grafted chitosan oligosaccharide comprising a structural unit represented by the following Formula (I) and a structural unit represented by the following Formula (II) and synthesize method, wherein the chitosan oligosaccharide has a molecular weight of less than 200,000 Da, and a degree of deacetylation of 70%-100%, and part of free amino groups of chitosan oligosaccharide chain are replaced by a fatty acid or PEG, where n refers to degree of polymerization of the PEG, and R is an alkyl group having 11-21 carbon atoms. The grafting ratio of fatty acids is 1%-50%, and the grafting ratio of PEG is 0.05%-50%. The present invention also comprise a pharmaceutical composition comprising the PEGylated and fatty acid grafted chitosan oligosaccharide as a carrier, and use of the PEGylated and fatty acid grafted chitosan oligosaccharide in preparation of a pharmaceutical composition.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: June 18, 2013
    Assignee: Zhejiang University
    Inventors: Fuqiang Hu, Yongzhong Du, Hong Yuan, Pan Meng
  • A PEGYLATED AND FATTY ACID GRAFTED CHITOSAN OLIGOSACCHARIDE, SYNTHESIS METHOD AND APPLICATION FOR DRUG DELIVERY SYSTEM
    Publication number: 20110118200
    Abstract: The present invention provides a PEGylated and fatty acid grafted chitosan oligosaccharide comprising a structural unit represented by the following Formula (I) and a structural unit represented by the following Formula (II) and synthesize method, wherein the chitosan oligosaccharide has a molecular weight of less than 200,000 Da, and a degree of deacetylation of 70%-100%, and part of free amino groups of chitosan oligosaccharide chain are replaced by a fatty acid or PEG, where n refers to degree of polymerization of the PEG, and R is an alkyl group having 11-21 carbon atoms. The grafting ratio of fatty acids is 1%-50%, and the grafting ratio of PEG is 0.05%-50%. The present invention also comprise a pharmaceutical composition comprising the PEGylated and fatty acid grafted chitosan oligosaccharide as a carrier, and use of the PEGylated and fatty acid grafted chitosan oligosaccharide in preparation of a pharmaceutical composition.
    Type: Application
    Filed: June 16, 2009
    Publication date: May 19, 2011
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Fuqiang Hu, Yongzhong Du, Hong Yuan, Pan Meng