Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

Abstract: A system and method is provided for pivoting a pilot on a model train, thereby allowing the model train to maneuver around a section of a model train track having a relatively small radius. In one embodiment of the present invention, the model train includes a frame, a shell connected to the frame, at least one truck assembly, at least one pilot and at least one coupler, wherein the coupler includes a coupler assembly and a coupler arm. The pilot is connected to a pilot arm, and the pilot arm, the coupler arm and the truck assembly are pivotally attached to the frame (e.g., via common or different pivots). In another embodiment of the present invention, the model train shell includes an aperture configured to receive a pilot arm. The pilot arm is connected to the pilot, which includes an aperture adapted to receive a coupler arm. The shell aperture is sized to allow the pilot arm to pivot from side to side, and the pilot aperture is sized to allow the coupler arm to pivot from side to side.

Abstract: A system and method is provided for pivoting a pilot on a model train, thereby allowing the model train to maneuver around a section of a model train track having a relatively small radius. In one embodiment of the present invention, the model train includes a frame, a shell connected to the frame, at least one truck assembly, at least one pilot and at least one coupler, wherein the coupler includes a coupler assembly and a coupler arm. The pilot is connected to a pilot arm, and the pilot arm, the coupler arm and the truck assembly are pivotally attached to the frame (e.g., via common or different pivots). In another embodiment of the present invention, the model train shell includes an aperture configured to receive a pilot arm. The pilot arm is connected to the pilot, which includes an aperture adapted to receive a coupler arm. The shell aperture is sized to allow the pilot arm to pivot from side to side, and the pilot aperture is sized to allow the coupler arm to pivot from side to side.