Abstract: The present invention provides: an extracellular matrix of which the biocompatibility is greatly increased through fat removal and decellularization and which contains growth factors so as to control physiological activities of cells; and a method for preparing the same. In addition, the extracellular matrix may be effectively obtained through a solvent extraction process using supercritical fluid, and a preservation solution comprising the extracellular matrix may be preserved for a long time by preventing contamination, and has increased manageability so that usability of the extracellular matrix may be greatly increased.

Abstract: Provided is a method for extracting an extracellular matrix with a supercritical fluid, comprising (a) injecting an extracted adipose tissue into a reactor, (b) pressurizing a solvent to prepare a supercritical fluid, and (c) introducing the supercritical fluid into the reactor to decellularize and delipidate the adipose tissue, and thereby extracting an extracellular matrix.