Abstract: This disclosure relates to aminopiperidine amides, derivatives, pharmaceutical compositions, and uses related to CXCR4 modulation. In certain embodiments, the aminopiperidine amides are compounds having formula I, salts, derivatives, and prodrugs thereof wherein, R1, R2, and R3 are further defined herein. In certain embodiments, this disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, this disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.

Abstract: This disclosure relates to chimeric compounds and methods for managing neurological conditions. In certain embodiments, the compound comprises a chemical structure of a monoamine reuptake inhibitor conjugated to a chemical structure of a histone deacetylase inhibitor. In certain embodiments, this disclosure relates to methods of treating or preventing a neurological disorder, mental disorder or depression comprising administering an effective amount of a compound disclosed herein to a subject in need thereof.

Abstract: Disclosed are catalyst preparation olefin polymerization processes with the recycling of a co-catalyst. According to the olefin polymerization process activated single-site catalysts are prepared by contacting supported single-site pre-catalyst with an organic solvent containing co-catalyst. The activated single-site catalysts are separated from co-catalysts dissolved in an organic solvent and the olefin polymerization is conducted using the separated single-site catalysts with one or more olefinic monomers. The separated co-catalysts is reused by recycling the organic solvent containing the separated co-catalysts and contacting them with the supported single-site pre-catalysts. The olefin polymerization process of the present invention enables recycling expensive co-catalyst for subsequent olefin polymerization and accordingly the total amount of co-catalyst required can be significantly reduced.