Abstract: Provided are a method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets, and a medical imaging device for simultaneously detecting multiple targets using the method. The method includes: injecting at least one marker particle comprising Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. The simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical fibers. As an examination may be performed by injecting surface-enhanced Raman marker particles, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time.

Abstract: The present invention relates to a method for separating nanoparticles and analyzing a biological substance using a microfluidic chip. The microfluidic chip of the present invention is effective in more sensitively and precisely detecting an analyte. According to the present invention, the use of the microfluidic chip enables the separation of nanoparticles through separation holes on the basis of size, achieving highly reliable analysis of a biological substance. In conclusion, the microfluidic chip of the present invention uses separation holes adapted to the size of nanoparticles to greatly increase the reliability of analysis of a biological substance, which will contribute to a marked improvement in the reliability of analysis based on microfluidics and a microfluidic system.

Abstract: Provided is a nanoprobe based on a self-replicating biological material. The nanoprobe includes a binding agent existing in a first region of the biological material and capable of binding specifically to a target analyte, and nanoparticles existing in a second region of the biological material and providing an optical detection signal. The use of the nanoprobe enables quantitative analysis and multiplexed analysis of a target. In addition, the nanoprobe is easy to fabricate on a large scale.

Abstract: Method pertains to a medical imaging device for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets. The method includes: injecting at least one marker particle including Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. The simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical fibers. As an examination may be performed by injecting surface-enhanced Raman marker particles, into which fluorescent components are introduced, into the body of the animal using a spray or the like, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time.

Abstract: The present invention relates to a seed-conjugated polymer support. In particular, the present invention is directed to a seed-conjugated polymer support for aggregating biomolecules, a method for preparing the same, and a method for removing ?-2-microglobulin.

Abstract: Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering.

Abstract: Provided is a protein detection system using a micro-cantilever and based on immune responses, wherein the micro-cantilever shows significantly improved sensitivity to allow detection of a trace amount of biomolecule. To the micro-cantilever, sandwich immunoassay is applied, and the sandwich immunoassay uses a polyclonal antibody or silica nanoparticles having a monoclonal antibody bound thereto, so that variations in the output signals of the cantilever are amplified and the detection sensitivity is significantly improved. The system enables detection of disease specific antigen at several femtomolar levels, and makes it possible to detect a trace amount of protein related to diseases, particularly to cancers, with ease.

Abstract: There is provided a method for manufacturing a surface enhanced Raman scattering nano-tagging particle, the method including the steps of: introducing silver nanoparticles on the surface of a silica core particle; immobilizing tagging materials and silica shell precursors on the silver nanoparticles; and forming a silica shell surrounding the silica core particle to which the tagging materials and the silica shell precursor are immobilized.

Abstract: There is provided a method for manufacturing a surface enhanced Raman scattering nano-tagging particle, the method including the steps of: introducing silver nanoparticles on the surface of a silica core particle; immobilizing tagging materials and silica shell precursors on the silver nanoparticles; and forming a silica shell surrounding the silica core particle to which the tagging materials and the silica shell precursor are immobilized.

Abstract: Provided is a method for screening a biological molecule rapidly and economically with high-throughput using microbeads encoded with silver nanoparticles and a chemical compound and dielectrophoresis. A biological screening method particularly utilizes microbeads encoded with silver nanoparticles and a specific chemical compound and dielectrophoresis. Since this screening method does not use a fluorescent material and a dying agent, which are typically used in the conventional screening method, it is non-toxic and economical. Also, this screening method allows simultaneous identification of many target materials. Accordingly, a leading compound can be screened within a short period of time, and thus, this screening method can be implemented as an economical and effective system for developing new pharmaceutical products.

Abstract: Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering.

Abstract: Disclosed is an expanded organic foam material having excellent thermal resistance and durability. The expanded plastic foam material is produced by preparing plastic beads or plastic foams, modifying silicate with at least one selected from among an alkaline earth metal compound, an alkaline earth metal compound-containing material, and an acid, coating the modified silicate on the prepared plastic beads or plastic foams, melt-molding the coated plastic beads or plastic foams while applying heat and pressure thereto, and drying the molded material. Also, the expanded organic plastic foam material has good impact-absorbing properties, easy formability, excellent sound-insulating and sound-absorbing performance and thermal insulating performance, good flame retardancy and thermal resistance, and improved water resistance and durability.

Abstract: The present invention relates to an aminomethyl polystyrene resin wherein aminomethyl group is grafted only on the surface of polystyrene resin, and a preparation process for the same. More particularly, the present invention is directed to a process for preparing aminomethyl polystyrene resin wherein aminomethyl group is grafted only on the surface of polystyrene resin, which comprises a step for grafting amidomethyl group to surface of polystyrene resin and a step for hydrolysis of the amidomethyl group grafted on the surface of polystyrene resin.

Abstract: The present invention relates to an aminomethyl polystyrene resin wherein aminomethyl group is grafted only on the surface of polystyrene resin, and a preparation process for the same. More particularly, the present invention is directed to a process for preparing aminomethyl polystyrene resin wherein aminomethyl group is grafted only on the surface of polystyrene resin, which comprises a step for grafting amidomethyl group to surface of polystyrene resin and a step for hydrolysis of the amidomethyl group grafted on the surface of polystyrene resin.

Abstract: An adsorbent, polystyrene spherical resin grafted with polyethylene glycol characterized in that polystyrene resin is crosslinked with 1 to 10 wt % of divinylbenzene, the content of polyethylene glycol is more than 50 wt % and the molecular weight of polyethylene glycol part, is more than 500 Da, is described. In addition processes for decontaminating dye contained in waste water of dye industry, heavy metal ion contained in waste water, surfactant, humic substance contained in trash sediment effectively and quickly by using the said adsorbent, are disclosed.

Abstract: The nitration of aromatic compounds is achieved in high yield and selectivity by using oxygen activated by an inorganic catalyst and nitrogen dioxide. Since this process uses neither concentration nitric nor sulfuric acids, the generation of spent waste acid does not occur. Furthermore, the process does not encounter the problem of high costs associated with the generation of ozone as in an alternative nitration process. Since the solubility of oxygen in a reaction medium is increased by using pressurized oxygen, nitrogen dioxide is activated by a porous inorganic oxide and thus an aromatic compound(e.g., benzene) is nitrated into a nitro compound (e.g., PhNO2), the reaction rate is significantly increased, and the recovery of reactants is easy due to the insolubility of the catalyst.