Abstract: Provided herein are novel anti-CD28×anti-TROP2 antibodies and methods of using such antibodies for the treatment of TROP2-associated cancers. Subject anti-CD28×anti-TROP2 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and TROP2 on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies, including, for example, bispecific antibodies for the treatment of TROP2-associated cancers.

Abstract: One embodiment provides a method comprising receiving content for presentation on a display, and obtaining a plurality of image patches from the content. Each image patch is segmented from a bottom and horizontal-center portion of a sub-sampled grayscale image of a frame of the content. The method further comprises applying a searching algorithm to the plurality of image patches to detect a region of interest of moving text in the content. The searching algorithm utilizes a first set of features and a second set of features to detect the region of interest with respect to a vertical axis and a horizontal axis of the display, respectively. The method further comprises correcting one or more visual artifacts in the region of interest, where the one or more visual artifacts include broken text.

Abstract: One embodiment provides a method comprising receiving content for presentation on a display, and obtaining one or more sample frames of the content. The method further comprises generating a set of features based on one or more horizontal edge signals and one or more vertical edge signals of the one or more sample frames. The method further comprises utilizing a classification model to detect, based on the set of features, a region of interest of moving text in the one or more sample frames.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CD8 and NKG2D.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CD8 and NKG2D.

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

Abstract: The present invention relates to biomaterials that interact with and regulate immune functions, as well as implantable materials and devices. In one embodiment, the present invention provides an implantable medical device comprising a biomaterial coated with one or more CD200 molecules. In another embodiment, the present invention provides a method of treating inflammation by administering a composition comprising one or more biomaterials that inhibit immune reactivity.

Abstract: The present invention relates to biomaterials that interact with and regulate immune functions, as well as implantable materials and devices. In one embodiment, the present invention provides an implantable medical device comprising a biomaterial coated with one or more CD200 molecules. In another embodiment, the present invention provides a method of treating inflammation by administering a composition comprising one or more biomaterials that inhibit immune reactivity.

Abstract: In an aspect, the present disclosure provides a composition for moisturizing skin, which contains a bamboo sap and a betaine as active ingredients. Specifically, the composition exhibits skin moisturizing effect by regulating natural moisturizing factors (NMFs) and is useful as a cosmetic composition, a pharmaceutical composition or a health food composition effective in moisturizing skin.

Abstract: Provided are a semiconductor device and a method of fabricating the same. The semiconductor device includes a first bit line structure extending in a first direction, a second bit line structure extending in the first direction and spaced apart from the first bit line structure, a storage contact plug located between the first bit line structure and the second bit line structure, and extending in a second direction perpendicular to the first direction, a first plug insulator located between the first bit line structure and the second bit line structure, and configured to contact a side surface extending in the second direction of the storage contact plug, and a plug isolation pattern located between the first bit line structure and the first plug insulator.

Abstract: Disclosed is an intelligent information providing system including: a user terminal requesting a registration of an intent for a word selected from a content recorded on a memo pad and receiving information related to the registered intent or style information on a role model in a group related to the intent; and an information management device registering the intent requested by the user terminal and providing the information related to the registered intent or the style information on the role model in the group related to the intent to the user terminal.

Abstract: Provided are a semiconductor device and a method of fabricating the same. The semiconductor device includes a first bit line structure extending in a first direction, a second bit line structure extending in the first direction and spaced apart from the first bit line structure, a storage contact plug located between the first bit line structure and the second bit line structure, and extending in a second direction perpendicular to the first direction, a first plug insulator located between the first bit line structure and the second bit line structure, and configured to contact a side surface extending in the second direction of the storage contact plug, and a plug isolation pattern located between the first bit line structure and the first plug insulator.

Abstract: A method of operation of a display system includes: receiving an input image having input pixels; assigning a pixel information for the input pixels corresponding to a semantic category; detecting input background pixels from the input pixels with the pixel information; identifying input foreground pixels from the input pixels with the background pixels; assigning a pixel depth to the input background pixels and input foreground pixels; generating a depth map with the input background pixels and the input foreground pixels; and generating a processed image from the input image with the depth map for displaying on a device.