Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: Proposed are an unsupported metallic catalyst for a selective ring-opening (SRO) reaction and a method of using the same catalyst, wherein the catalyst contains nickel (Ni), molybdenum (Mo), and tungsten (W).

Abstract: A display device includes a substrate including an active area having pixels and a non-active area including a pad region. A pad electrode is disposed in the pad region and includes a first pad electrode and a second pad electrode disposed on the first pad electrode. A first insulating pattern is interposed between the first and second pad electrodes. In a plan view, the first insulating pattern is positioned inside the first pad electrode, and a portion of the second pad electrode overlapping the first insulating pattern protrudes further from the substrate in a thickness direction than a portion of the second pad electrode not overlapping the first insulating pattern. The second pad electrode directly contacts a portion of the upper surface of the first pad electrode. In a plan view, an area of the second pad electrode is greater than an area of the first pad electrode.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CD8 and NKG2D.

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

Abstract: The present invention relates to biomaterials that interact with and regulate immune functions, as well as implantable materials and devices. In one embodiment, the present invention provides an implantable medical device comprising a biomaterial coated with one or more CD200 molecules. In another embodiment, the present invention provides a method of treating inflammation by administering a composition comprising one or more biomaterials that inhibit immune reactivity.

Abstract: The present invention relates to biomaterials that interact with and regulate immune functions, as well as implantable materials and devices. In one embodiment, the present invention provides an implantable medical device comprising a biomaterial coated with one or more CD200 molecules. In another embodiment, the present invention provides a method of treating inflammation by administering a composition comprising one or more biomaterials that inhibit immune reactivity.

Abstract: In an aspect, the present disclosure provides a composition for moisturizing skin, which contains a bamboo sap and a betaine as active ingredients. Specifically, the composition exhibits skin moisturizing effect by regulating natural moisturizing factors (NMFs) and is useful as a cosmetic composition, a pharmaceutical composition or a health food composition effective in moisturizing skin.

Abstract: Provided are a semiconductor device and a method of fabricating the same. The semiconductor device includes a first bit line structure extending in a first direction, a second bit line structure extending in the first direction and spaced apart from the first bit line structure, a storage contact plug located between the first bit line structure and the second bit line structure, and extending in a second direction perpendicular to the first direction, a first plug insulator located between the first bit line structure and the second bit line structure, and configured to contact a side surface extending in the second direction of the storage contact plug, and a plug isolation pattern located between the first bit line structure and the first plug insulator.

Abstract: Disclosed is an intelligent information providing system including: a user terminal requesting a registration of an intent for a word selected from a content recorded on a memo pad and receiving information related to the registered intent or style information on a role model in a group related to the intent; and an information management device registering the intent requested by the user terminal and providing the information related to the registered intent or the style information on the role model in the group related to the intent to the user terminal.

Abstract: Provided are a semiconductor device and a method of fabricating the same. The semiconductor device includes a first bit line structure extending in a first direction, a second bit line structure extending in the first direction and spaced apart from the first bit line structure, a storage contact plug located between the first bit line structure and the second bit line structure, and extending in a second direction perpendicular to the first direction, a first plug insulator located between the first bit line structure and the second bit line structure, and configured to contact a side surface extending in the second direction of the storage contact plug, and a plug isolation pattern located between the first bit line structure and the first plug insulator.

Abstract: A method of operation of a display system includes: receiving an input image having input pixels; assigning a pixel information for the input pixels corresponding to a semantic category; detecting input background pixels from the input pixels with the pixel information; identifying input foreground pixels from the input pixels with the background pixels; assigning a pixel depth to the input background pixels and input foreground pixels; generating a depth map with the input background pixels and the input foreground pixels; and generating a processed image from the input image with the depth map for displaying on a device.

Abstract: Disclosed is an intelligent information providing system including: a user terminal requesting a registration of an intent for a word selected from a content recorded on a memo pad and receiving information related to the registered intent or style information on a role model in a group related to the intent; and an information management device registering the intent requested by the user terminal and providing the information related to the registered intent or the style information on the role model in the group related to the intent to the user terminal.

Abstract: The present invention relates to biomaterials that interact with and regulate immune functions, as well as implantable materials and devices. In one embodiment, the present invention provides an implantable medical device comprising a biomaterial coated with one or more CD200 molecules. In another embodiment, the present invention provides a method of treating inflammation by administering a composition comprising one or more biomaterials that inhibit immune reactivity.

Abstract: Provided is an image processing method and apparatus for improving image quality and enhancing a three-dimensional effect. By extracting an interest feature index from an input image based on a depth sensation estimation cue existing in the image, calculating an interest feature index integration map based on the interest feature index and importance of interest of the depth sensation estimation cue, and performing discrimination processing of the image based on the interest feature index integration map, three-dimensional effect and true sensation enhancement processing can be performed based on the probability of the existence of a depth sensation estimation cue, without segmentation of an object of interest, correct depth information, or an object model.

Abstract: A method of operation of a display system includes: receiving a current input image with current input pixels; identifying an input object, having input object pixels, based on differences in characteristics of the current input pixels; calculating an object pixel depth for the input object pixels from an image depth map of the current input image based on a weighted average of depth candidates; and generating a processed image, having a perceived depth, from the current input image with the image depth map and the object pixel depth for displaying on a device.