Abstract: Provided is a high-speed variant ChRmine protein having faster kinetic properties compared to a parent ChRmine protein, where the high-speed variant ChRmine protein has one or more amino acid substitutions compared to the parent ChRmine protein. Also provided is a red-shifted variant ChRmine protein having a red-shifted spectrum compared to a parent ChRmine protein, where the red-shifted variant ChRmine protein has one or more amino acid substitutions compared to the parent ChRmine protein. Further provided is a nucleic acid encoding for a variant ChRmine protein disclosed herein as well as a genetically modified cell comprising such nucleic acid. Additionally, provided is an optogenetic method that includes genetically modifying a subject to express in the subject's brain cells a variant ChRmine protein disclosed herein, applying stimulating light to the subject's brain, and imaging the subject's brain.

Abstract: According to an embodiment of the disclosure, an ultrasonic probe may be provided, the ultrasonic probe including a first housing, a second housing coupled to the first housing, an acoustic module at least partially arranged in the first housing and including a transducer and a lens portion, the transducer being capable of converting an ultrasonic signal and an electrical signal, and the lens portion being capable of changing a path of the ultrasonic signal, a first connector connected to an inner surface of the first housing, and a second connector at least partially arranged in the second housing and connected to the first connector, wherein the first connector is configured to connect the second connector and the first housing to each other, such that the first housing is coupled to the second housing.

Abstract: The present invention relates to an immune checkpoint inhibitor conjugated with an sonosensitizer, a use thereof, and the like. The immune checkpoint inhibitor conjugate conjugated with an sonosensitizer according to the present invention has selectivity for tumors with respect to targeted therapy and specifically responds to ultrasonic waves, and thus can be used to produce drugs for diagnosing and treating cancer. Particularly, the conjugate of the present invention exhibits excellent solubility and stability in an aqueous solution, and provides excellent anticancer effects as compared with simple immune checkpoint inhibitors, and therefore, is expected to be useful as a novel drug for treating cancer.

Abstract: Compositions and methods are provided for genetically modifying cells to guide in situ chemical synthesis of electroactive, conductive, or insulating polymers on plasma membranes, organelle membranes, or subcellular surfaces of cells. In particular, compositions and methods are provided for genetically modifying excitable cells such as neurons, muscle cells, and endocrine cells to guide in situ chemical synthesis of polymers on the extracellular side of the plasma membrane. The subject methods can be used in various applications, for example, to assemble polymers in vivo at targeted locations to modulate electrical conduction and create new electrical conduction pathways, allow cell-type-specific neuromodulation, provide a conductive structure on cells for connection to electrodes, sensors, or other external electronic and electrochemical devices, and create a durable structure to replace damaged tissue for use in regenerative medicine.

Abstract: The present disclosure provides recombinant expression vectors for modulating production of polypeptides of interest in a target cell or target cell population. Aspects of the disclosure include recombinant expression vectors having coding sequences encoding portions of a polypeptide of interest, where the coding sequences are flanked by recombinase recognition sites. Also provided are methods for using the recombinant expression vectors as well as a device for monitoring expression of the polypeptide of interest.

Abstract: The present disclosure relates to an ultrasonic probe used in a medical instrument for ultrasonic diagnosis, and the ultrasonic probe includes a strain relief having a structure for preventing a cable from being damaged by twisting or sharp bending.

Abstract: Provided is a method of distributing an application including transmitting, by a distribution server, a signal for requesting metadata to a user terminal where an application is installed; receiving, by the distribution server, a reply including first metadata from the user terminal; determining, by the distribution server, whether the first metadata is valid based on second metadata corresponding to the application; setting a connection with the user terminal to re-install the application on the user terminal if the distribution server determines that the first metadata is not valid; encrypting, by the distribution server, one or more installation files that install the application with a private key; and transmitting the one or more encrypted installation files via the set connection to the user terminal.

Abstract: Provided is a probe for an ultrasonic diagnostic apparatus. The probe includes: the transducer module including a transducer configured to transmit or receive ultrasound waves; a first casing positioned below the transducer module to support the transducer module; a second casing extending along a perimeter of the first casing and integrally formed with the first casing; and a heat spreader positioned below the transducer module and above the first casing, where the heat spreader is a sheet of metal.

Abstract: Provided is a method of distributing an application including transmitting, by a distribution server, a signal for requesting metadata to a user terminal where an application is installed; receiving, by the distribution server, a reply including first metadata from the user terminal; determining, by the distribution server, whether the first metadata is valid based on second metadata corresponding to the application; setting a connection with the user terminal to re-install the application on the user terminal if the distribution server determines that the first metadata is not valid; encrypting, by the distribution server, one or more installation files that install the application with a private key; and transmitting the one or more encrypted installation files via the set connection to the user terminal.

Abstract: The non-polar or semi-polar group III nitride layer disclosed in a specific example of the present invention can be used for substrates for various electronic devices, wherein problems of conventional polar group III nitride substrates are mitigated or solved by using the nitride substrate of the invention, and further the nitride substrate can be manufactured by a chemical lift-off process.

Abstract: An image forming apparatus includes a developing module which develops a toner image on a printing medium, a fixing module which fixes the toner image onto the printing medium, and a toner neutralization module arranged on a travel path of the printing medium between the developing module and the fixing module to electrically neutralize the toner image on the printing medium.

Abstract: The non-polar or semi-polar group III nitride layer disclosed in a specific example of the present invention can be used for substrates for various electronic devices, wherein problems of conventional polar group III nitride substrates are mitigated or solved by using the nitride substrate of the invention, and further the nitride substrate can be manufactured by a chemical lift-off process.

Abstract: An image forming apparatus includes a developing module which develops a toner image on a printing medium, a fixing module which fixes the toner image onto the printing medium, and a toner neutralization module arranged on a travel path of the printing medium between the developing module and the fixing module to electrically neutralize the toner image on the printing medium.

Abstract: The present invention relates to a light emitting diode with high electrostatic discharge and a fabrication method thereof, and more specifically to a light emitting diode comprising a first electrode layer provided over a upper surface of a first semiconductor layer and a upper surface of a second semiconductor layer; a transparent electrode layer formed on the upper surface of the second semiconductor layer, spaced from the first electrode layer; and a second electrode layer provided on a upper surface of the transparent electrode layer. With the present invention, there is provided a light emitting diode element with resistance against electrostatic discharge and with high reliability being strong against electrical impact, by selecting a structure arranging a form of an electrode differently from a conventional electrode.

Abstract: The present invention relates to a light emitting diode with high electrostatic discharge and a fabrication method thereof, and more specifically to a light emitting diode comprising a first electrode layer provided over a upper surface of a first semiconductor layer and a upper surface of a second semiconductor layer; a transparent electrode layer formed on the upper surface of the second semiconductor layer, spaced from the first electrode layer; and a second electrode layer provided on a upper surface of the transparent electrode layer. With the present invention, there is provided a light emitting diode element with resistance against electrostatic discharge and with high reliability being strong against electrical impact, by selecting a structure arranging a form of an electrode differently from a conventional electrode.