Abstract: The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27 bladder, 38 cervical, and 17 prostate cancers, for the BRAF T1796A mutation by polymerase chain reaction (PCR)-restriction enzyme analysis of BRAF exon 15. In 24 (69%) of the 35 papillary thyroid carcinomas examined, we found a missense thymine (T)?adenine (A) transversion at nucleotide 1796 in the BRAF gene (T1796A). The T1796A mutation was detected in four lung cancers and in six head and neck cancers but not in bladder, cervical, or prostate cancers. Our data suggested that activating BGRAF mutations may be an important even in the development of papillary thyroid cancer. Moreover, BRAF mutation reliably predicts a poor prognosis for papillary thyroid carcinomas.

Abstract: A monitoring system and a method for monitoring a reverse osmosis (RO) membrane in an RO unit is capable of detecting the formation of mineral salt crystals on the surface of the RO membrane. The monitoring system includes a reverse osmosis monitoring cell coupled to the RO unit so as to receive a sample stream taken from either the feed stream to, or the concentrate stream from, the RO unit. The cell has a visually observable RO membrane that is visible to an imaging system that creates and collects images of the visually-observable RO membrane, and that conveys an image data signal to a data processing system that is operable to translate the image data signal into visual images for display, and to correlate the data in the image data signal with a scaling condition on the RO membrane in the RO unit.

Abstract: A vacuum extractor for obstetrical use comprises a vacuum cup at one end of an elongated stem having a handle at the opposite end. The vacuum cup is sealed over a portion of the head of the fetus and a vacuum source, usually operating through the stem, connects to the inner side of the cup and secures it to the fetal head. A strain sensor is connected to the stem. When the force applied to the cup through the handle and stem exceeds a predetermined maximum, a valve connecting the vacuum pressure to the atmosphere is opened so as to release the vacuum pressure from the cup. Another extractor comprises an elongated hollow stem having one or more apertures along its length, a vacuum source connected to a cup supported on the stem, and a handle member which includes a traction limiting element operative to open and close the apertures.

Abstract: An optical relay comprises a light-transmissive substrate having a plurality of diffractive optical elements, where at least one diffractive optical element is characterized by nonuniform diffraction efficiency. The substrate and diffractive optical elements are designed and constructed to relay at least a portion of a light beam emanating from an object to at least one predetermined eye-box in a manner such that for each point of the object, there is a set of parallel outgoing light rays originating from the point and arriving to the eye-box. The color difference between any two parallel light rays of the set is less than 50 ?E* units.

Abstract: A liquid testing assembly for testing a liquid, the assembly comprising a test vessel and a stopper adapted to fit into a free end of the vessel. The stopper substantially hermetically seals the test vessel from the ambient. Further, the assembly includes a support coated with one or more identifying materials for identifying one or more constituents of the liquid. The support is fixed in the stopper and/or the vessel and extends into its interior for a predetermined distance. The liquid testing assembly when assembled is pre-evacuated to a predetermined vacuum sufficient to draw a predetermined volume of liquid to be sampled into the test vessel. The predetermined volume is of such an amount that it wets the one or more identifying materials ensuring identification of one or more constituents present in the liquid. A kit employing the liquid testing assembly is also discussed.

Abstract: A method of modifying a polymeric, inorganic, or organic-functionalized substrate surface is provided. In one embodiment, an atmospheric pressure (AP) plasma stream is directed at a substrate surface, leading to the formation of surface-bound active sites that function as polymerization initiators. When contacted with a monomer or monomer solution, the active sites facilitate formation of a dense array of graft polymers covalently bound to the substrate surface. In another embodiment, an inorganic substrate is cleaned, conditioned in a humidity chamber, treated with an AP plasma, and contacted with a monomer or monomer solution to facilitate formation and growth of graft polymers on the substrate surface.

Abstract: In one embodiment, a method of modifying a surface of a substrate includes activating the surface of the substrate, and polymerizing the surface of the substrate. The polymerizing including subjecting the surface of the substrate to a monomer solution at a temperature of between 105° C. and 130° C. for a first period of time and subjecting the surface of the substrate to the monomer solution at a temperature of between 70° C. and 90° C. for a second period of time different than the first period of time. In another embodiment, a method of modifying a surface of a substrate includes activating the surface of the substrate, and graft polymerizing a vinyl monomer onto the surface of the substrate. The polymerizing including subjecting the surface of the substrate to a mixture including a monomer solution and 2,2,6,6-tetramethyl-1-piperidinyloxy at a concentration of between 5 and 20 mM. In another embodiment, an apparatus includes a substrate having a surface.

Abstract: In one embodiment, a method of modifying a surface of a membrane includes exposing the surface to an impinging atmospheric pressure plasma source to produce an activated surface, and exposing the activated surface to a solution including a vinyl monomer. In another embodiment, a method of manufacturing a desalination membrane includes treating a surface of the membrane with an impinging atmospheric plasma source for an optimal period of time and rf power, and exposing the surface to an aqueous solution containing a vinyl monomer. In another embodiment, an apparatus includes a membrane having a surface, and polymer chains terminally grafted onto the surface of the membrane.

Abstract: A disposable inoculation loop assembly comprising a test tube and a tube stopper adapted to fit into a free end of the test tube. A first end of the stopper faces into the interior of the test tube substantially hermetically sealing the interior of the test tube. The assembly further includes an inoculation loop fixed to the tube stopper and extending into the interior of the test tube to a predetermined distance when the stopper is positioned in the free end of the test tube. The assembly when assembled is sterilized and pre-evacuated to a predetermined vacuum which is sufficient to draw a volume of a bodily liquid to be sampled into the test tube. The volume is of such an amount so that the liquid level in the test tube substantially just covers a predetermined portion of the inoculation loop.

Abstract: A delivery extractor for use with a vacuum suction source and at least one monitor in vacuum assisted deliveries. The extractor comprises a cup-shaped element and a tubular stem joined to the cup-shaped element and in pneumatic communication with the vacuum suction source. The extractor also includes at least one non-invasive sensor positioned on and in mechanical communication with a sensor support so as to continuously contact the scalp of a fetus when the head of the fetus is positioned in the cup-shaped element. The sensor support is compressible within the cup-shaped element. The at least one sensor is in communication with the at least one monitor which monitors at least one physiological indicator of the well-being of the fetus during its transit through the birth canal. The invention also includes a system and method for using the above extractor.

Abstract: A disposable plastic vaginal speculum constructed for heavy duty use and/or for long duration gynecological procedures including intrauterine device insertion and vaginal surgical procedures. The hinge region of the speculum, as well as other regions, are reinforced so that the speculum can bear forces of a magnitude normally bearable only by metal vaginal specula.

Abstract: A monitoring system and a method for monitoring a reverse osmosis (RO) membrane in an RO unit is capable of detecting the formation of mineral salt crystals on the surface of the RO membrane. The monitoring system includes a reverse osmosis monitoring cell coupled to the RO unit so as to receive a sample stream taken from either the feed stream to, or the concentrate stream from, the RO unit. The cell has a visually observable RO membrane that is visible to an imaging system that creates and collects images of the visually-observable RO membrane, and that conveys an image data signal to a data processing system that is operable to translate the image data signal into visual images for display, and to correlate the data in the image data signal with a scaling condition on the RO membrane in the RO unit.

Abstract: The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27 bladder, 38 cervical, and 17 prostate cancers, for the BRAF T1796A mutation by polymerase chain reaction (PCR)-restriction enzyme analysis of BRAF exon 15. In 24 (69%) of the 35 papillary thyroid carcinomas examined, we found a missense thymine (T)?adenine (A) transversion at nucleotide 1796 in the BRAF gene (T1796A). The T1796A mutation was detected in four lung cancers and in six head and neck cancers but not in bladder, cervical, or prostate cancers. Our data suggested that activating BGRAF mutations may be an important even in the development of papillary thyroid cancer. Moreover, BRAF mutation reliably predicts a poor prognosis for papillary thyroid carcinomas.

Abstract: The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27 bladder, 38 cervical, and 17 prostate cancers, for the BRAF T1796A mutation by polymerase chain reaction (PCR)-restriction enzyme analysis of BRAF exon 15. In 24 (69%) of the 35 papillary thyroid carcinomas examined, we found a missense thymine (T)?adenine (A) transversion at nucleotide 1796 in the BRAF gene (T1796A). The T1796A mutation was detected in four lung cancers and in six head and neck cancers but not in bladder, cervical, or prostate cancers. Our data suggest that activating BRAF mutations may be an important event in the development of papillary thyroid cancer. Moreover, BRAF mutation reliably predicts a poor prognosis for papillary thyroid carcinomas.

Abstract: An instrument guard for a MIS medical device includes an attachment portion and an instrument holding portion. The attachment portion is removably attachable to a containment tube of a medical device used for minimally invasive surgery. The instrument holding portion is used to contain and insulate surgical instruments used for the procedure. The instrument guard may be removed after use, exposing the surgical instruments and allowing for cleaning thereof, by washing, brushing, ultrasonic cleaning and visual inspection. A clean instrument guard is then placed on the device, enabling the device to be reused in another procedure.

Abstract: The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27 bladder, 38 cervical, and 17 prostate cancers, for the BRAF T1796A mutation by polymerase chain reaction (PCR)-restriction enzyme analysis of BRAF exon 15. In 24 (69%) of the 35 papillary thyroid carcinomas examined, we found a missense thymine (T)?adenine (A) transversion at nucleotide 1796 in the BRAF gene (T1796A). The T1796A mutation was detected in four lung cancers and in six head and neck cancers but not in bladder, cervical, or prostate cancers. Our data suggest that activating BRAF mutations may be an important event in the development of papillary thyroid cancer. Moreover, BRAF mutation reliably predicts a poor prognosis for papillary thyroid carcinomas.

Abstract: A method for spatial imaging of neuronal biological material using diffusion based magnetic resonance imaging (MRI) techniques. The method is comprised of (i) exposing a neuronal biological material region to a series of diffusion weighted MRI sequences producing plurality of non mono-exponential decay signals; (ii) analyzing the non mono-exponential decay signals and obtaining a parameter reflecting the diffusion characteristic of the slow diffusing component; and (iii) forming an array of these parameters thereby obtaining the spatial image of the neuronal biological material region.

Abstract: A ceramic-supported polymer membrane is disclosed where a porous ceramic membrane support of average pore size no larger than 500 Å is activated by attaching a vinyl terminated lower alkoxy silane to the surface of the ceramic membrane pores. The resulting membrane retains at least 10 micromoles of the vinyl terminated loweralkoxy silane per square meter of the ceramic membrane surface. A method for optimizing the amount of vinyl loweralkoxy silane reacted with the ceramic support surface is also disclosed. The large amount of vinyl terminated loweralkoxy silane which is chemically bonded to the surface of the ceramic porous support produces activated ceramic membrane support surface which is useful for graft polymerization of vinyl monomers onto the porous ceramic membrane support surface. A vinyl monomer is then graft polymerized onto the activated membrane.

Abstract: According to the teachings of the present invention there is provided a videophone system utilizing a set-top box (STB) and a server to provide full duplex transmission of audio and video signals over a cable television network, comprising: (a) a first element providing data signals; (b) a compression unit for compressing the signals into a first set of compressed signals; (c) a server designed and configured for converting the first set of compressed signals to a second set of compressed signals, and (d) an STB having a built-in, hardware decompression unit, and operationally connected to the first element and to the server, wherein the STB is designed and configured for: (i) transferring the first set of compressed signals to a server, and (ii) decompressing a set of compressed signals received from the server.

Abstract: Separation resins are disclosed where silica particles are surface activated by attaching a vinyl terminated lower alkoxy silane to the silica particle and then hydrolyzing the particles. The resulting hydrolyzed particles are hydrophilic and retain at least 10 micromoles of the hydrolyzed vinyl terminated lower alkoxy silane per square centimeter of the silica. A water soluble polymer is then graft polymerized onto the activated and hydrolyzed silica particles. The large amount of hydrolyzed vinyl terminated lower alkoxy silane which remains on the silica along with the hydrophilic nature of the hydrolyzed silica produces an activated particle which is useful for graft polymerization of water soluble polymers onto the particles in large amounts not previously possible. A method for preparing the separation resins is also disclosed.