Patents by Inventor Yoram Kapulnik

Yoram Kapulnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11833131
    Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: December 5, 2023
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research, Mor Research Applications Ltd.
    Inventors: Hinanit Koltai, Yoram Kapulnik, Moran Mazuz, Timna Naftali
  • Patent number: 11331301
    Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: May 17, 2022
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Mor Research Applications Ltd.
    Inventors: Hinanit Koltai, Yoram Kapulnik, Dvora Namdar, Moran Mazuz, Ido Laish, Timna Naftali
  • Publication number: 20210290712
    Abstract: The present invention is directed to a composition consisting essentially of epigallocatechin, mannofuranose, ?-D-xylopyranose, gallic acid, palmitic acid, stearic acid, trans-catechin, cis-catechin, and an acceptable carrier, and a method of using same, such as for treating an inflammatory disease.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 23, 2021
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Einav MAYZLISH GATI, Nasser AHMED, Shemer BEN ZION
  • Patent number: 10960035
    Abstract: Polar extracts of Erodium plants are disclosed as well as pharmaceutical compositions and cosmetic compositions comprising same. Uses of the polar extracts are also disclosed.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: March 30, 2021
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Voleaui Center), The Economic Company For The Development Of Ramat Hanegev Ltd.
    Inventors: Hinanit Koltai, Yoram Kapulnik, Marcelo Fridlender, Einav Mayzlish Gati, Nasser Ahmed, Shemer Ben Zion
  • Publication number: 20200222359
    Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 16, 2020
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Moran MAZUZ, Timna NAFTALI
  • Publication number: 20200030282
    Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a Cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a Cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises Cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises Cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.
    Type: Application
    Filed: March 5, 2018
    Publication date: January 30, 2020
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Dvora NAMDAR, Moran MAZUZ, Ido LAISH, Timna NAFTALI
  • Publication number: 20190100731
    Abstract: A method of preparing an ex-vivo intestinal culture model is provided. The method comprising: (a) providing an intestinal tissue sample; (b) treating the intestinal tissue sample with a protease cleaving an extracellular matrix (ECM) component so as to break cell-cell contacts and obtain an intestinal preparation which maintains the overall intestinal tissue structure including villi and/or intestinal tissue layer orientation; (c) washing the preparation; and (d) culturing the preparation.
    Type: Application
    Filed: March 17, 2017
    Publication date: April 4, 2019
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Timna NAFTALI
  • Patent number: 10208007
    Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: February 19, 2019
    Inventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi
  • Publication number: 20180235213
    Abstract: A composition comprising at least one polymer, characterized by a surface energy having a value that ranges from 20 mJ/m2 to 60 mJ/m2, and an active agent (e.g., a plant hormone) is disclosed. A delivery device comprising the disclosed composition, adapted for installation on a part of a plant, is further disclosed. A method for applying a plant hormone to a plant is further disclosed.
    Type: Application
    Filed: May 11, 2016
    Publication date: August 23, 2018
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Smadar WEININGER
  • Publication number: 20180092954
    Abstract: Polar extracts of Erodium plants are disclosed as well as pharmaceutical compositions and cosmetic compositions comprising same. Uses of the polar extracts are also disclosed.
    Type: Application
    Filed: March 31, 2016
    Publication date: April 5, 2018
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Einav MAYZLISH GATI, Nasser AHMED, Shemer BEN ZION
  • Publication number: 20140323563
    Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 30, 2014
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Georgetown University
    Inventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi
  • Patent number: 8785721
    Abstract: The present invention relates to tomato plants that are resistant to pathogenic plants of the Orobanchaceae family, to methods for producing said plants and to the use thereof. The invention further relates to a method of controlling parasitic plants of the Orobanchaceae family, particularly O. aegyptiaca, in tomato crops and for securing tomato fruit production.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: July 22, 2014
    Assignee: State of Israel, Ministry of Agriculture
    Inventors: Joseph Hershenhorn, Evgenia Dor, Yoram Kapulnik, Samdar Goldar Weininger, Bruria Ben Dor
  • Publication number: 20110258732
    Abstract: The present invention relates to tomato plants that are resistant to pathogenic plants of the Orobanchaceae family, to methods for producing said plants and to the use thereof. The invention further relates to a method of controlling parasitic plants of the Orobanchaceae family, particularly O. aegyptiaca, in tomato crops and for securing tomato fruit production.
    Type: Application
    Filed: November 18, 2009
    Publication date: October 20, 2011
    Inventors: Joseph Hershenhorn, Evgenia Dor, Yoram Kapulnik, Samdar Goldar Weininger, Bruria Ben Dor
  • Patent number: 7385106
    Abstract: A method of generating a plant tolerant of environmental stress conditions, the method comprising the step of expressing within the plant exogenous polynucleotides encoding enzymes capable of catalyzing proline production, wherein the exogenous polynucleotides are expressed in a manner so as to allow accumulation of the enzymes within a subcellular organelle of the plant. The invention further describes novel polynucleotides and nucleic acid constructs useful in implementing the methods and a transgenic plant resultant therefrom.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: June 10, 2008
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Hanan Stein, Aviah Zilberstein, Gadi Miller, Yoram Kapulnik
  • Patent number: 7060872
    Abstract: The inventions are methods of generating a plant having modified canopy size or having seedless fruit by transformation with a construct encoding streptavidin operably linked to a secretion signal peptide capable and selecting plants with degeneration of young leaf and/or shoot tissue or degeneration of embryonic tissue, respectively.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: June 13, 2006
    Assignee: The State of Israel-Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Yoram Kapulnik, Idit Ginzberg
  • Patent number: 6844484
    Abstract: A recombinant promoter which is functional in plant cells, the recombinant promoter comprises SEQ ID NO: 9.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: January 18, 2005
    Assignee: The State of Israel - Ministry of Agriculture & Rural Development
    Inventors: Yoram Kapulnik, Anat Kahana, Ayelet Bar-Akiva, Rozalina Ben-D V, Smadar Wininger, Idit Ginzberg
  • Publication number: 20040268438
    Abstract: A recombinant promoter which is functional in plant cells, the recombinant promoter comprises at least a minimal functional plant promoter region derived from SEQ ID NOs: 7 or 8.
    Type: Application
    Filed: July 23, 2004
    Publication date: December 30, 2004
    Applicant: Agricultural Research Organization, The Volcani Center
    Inventors: Yoram Kapulnik, Anat Kahana, Ayelet Bar-Akiva, Rozalina Ben-Dov, Smadar Wininger, Idit Ginzberg
  • Publication number: 20030211490
    Abstract: A method of generating a plant tolerant of environmental stress conditions, the method comprising the step of expressing within the plant exogenous polynucleotides encoding enzymes capable of catalyzing proline production, wherein the exogenous polynucleotides are expressed in a manner so as to allow accumulation of the enzymes within a subcellular organelle of the plant. The invention further describes novel polynucleotides and nucleic acid constructs useful in implementing the methods and a transgenic plant resultant therefrom.
    Type: Application
    Filed: October 30, 2002
    Publication date: November 13, 2003
    Inventors: Hanan Stein, Aviah Zilberstein, Gadi Miller, Yoram Kapulnik
  • Publication number: 20030101475
    Abstract: A recombinant promoter which is functional in plant cells, the recombinant promoter comprises at least a minimal functional plant promoter region derived from SEQ ID NOs: 7, 8 or 9.
    Type: Application
    Filed: October 23, 2001
    Publication date: May 29, 2003
    Applicant: Agricultural Research Organization, The Volcani Center
    Inventors: Yoram Kapulnik, Anat Kahana, Ayelet Bar-Akiva, Rozalina Ben-Dov, Smadar Wininger, Idit Ginzberg
  • Patent number: 5917117
    Abstract: The present invention provides methods by which hyperaccumulation of metals in plant shoots is induced by exposure to inducing agents. Hyperaccumulation occurs as part of a two-step process in which metals are first accumulated into plant roots; subsequent transport to plant shoots is induced by exposure to the agent. In preferred embodiments, manipulations that increase availability of metals to the plant are employed prior to application of the inducing agent. Effective inducing agents include conditions of low pH, chelators, herbicides, and high levels of heavy metals. Other phytotoxic agents are also useful. Application of multiple inducing agents results in synergistic effects.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: June 29, 1999
    Assignee: Phytotech, Inc.
    Inventors: Burt D. Ensley, Michael J. Blaylock, Slavik Dushenkov, Nanda P.B.A. Kumar, Yoram Kapulnik