Patents by Inventor Yoram Zilberman

Yoram Zilberman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY ENGINEERED CELLS WHICH EXPRESS BONE MORPHOGENIC PROTEINS
    Publication number: 20110111505
    Abstract: The present invention describes methods of producing cell lines which express recombinant DNA encoding bone morphogenetic proteins (BMP). The cell lines are capable of being implanted in order to enhance the regeneration of tissues through both autocrine and paracrine effects. The cells may further contain DNA encoding receptor proteins which are able to bind to BMPs or enhance or regulate BMP activity.
    Type: Application
    Filed: January 19, 2011
    Publication date: May 12, 2011
    Inventors: Ioannis MOUTSATSOS, Daniel Gazit, Yoram Zilberman, Gadi Turgeman
  • Methods and compositions for enhancing cartilage repair
    Publication number: 20060069053
    Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector, which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition-comprising cell that expresses a factor of the T-box family, which includes inter-alia the brachyury.
    Type: Application
    Filed: September 12, 2005
    Publication date: March 30, 2006
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, Gesellschaft Fuer Biotechnologische Forschung mbH - GBF
    Inventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Andrea Hoffmann
  • Methods and compositions for enhancing cartilage repair
    Patent number: 6849255
    Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: February 1, 2005
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Gesellschaft Fuer Biotechnologische Forschung MBH
    Inventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Stefan Czichos, Andrea Hoffmann
  • Methods of inducing or enhancing cartilage repair
    Publication number: 20040009157
    Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector, which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition-comprising cell that expresses a factor of the T-box family, which includes inter-alia the brachyury.
    Type: Application
    Filed: November 18, 2002
    Publication date: January 15, 2004
    Inventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Andrea Hoffmann
  • Methods of inducing or enhancing connective tissue repair
    Publication number: 20030185807
    Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.
    Type: Application
    Filed: February 8, 2002
    Publication date: October 2, 2003
    Inventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Stefan Czichos, Andrea Hoffmann
  • GENETICALLY ENGINEERED CELLS WHICH EXPRESS BONE MORPHOGENETIC PROTEINS
    Publication number: 20020102728
    Abstract: The present invention describes methods of producing cell lines which express recombinant DNA encoding bone morphogenetic proteins (BMP). The cell lines are capable of being implanted in order to enhance the regeneration of tissues through both autocrine and paracrine effects. The cells may further contain DNA encoding receptor proteins which are able to bind to BMPs or enhance or regulate BMP activity.
    Type: Application
    Filed: September 4, 1998
    Publication date: August 1, 2002
    Inventors: IOANNIS MOUTSATSOS, DAN GAZIT, YORAM ZILBERMAN, GADI TURGEMAN