Abstract: A plug member integrally includes a base portion (35a) attached to a plug holder (31) to be mounted on a mouth portion of a container, a plug (34) engaged with an engagement portion (31c) provided in an outlet passage of the plug holder (31), and a resilient connection portion (35b) resiliently connecting the plug (34) to the base portion (35a). Before the first use, the outlet passage is closed with the plug member. In the first use, the container is squeezed to increase the internal pressure of the container. Thus, the plug (34) is disengaged from the engagement portion (31c) by the internal pressure. The outlet passage is thereafter constantly kept open.

Abstract: A filtering discharge container employing a delaminatable bottle was provided, which reliably prevents a content liquid from leaking out before the first use, and reduces a discharging resistance during the second and subsequent use. An engagement portion (31c) is provided in an outlet passage of a mouth cap (3). A plug (34) is engaged with the engagement portion (31c) in such a manner that the plug (34) can be disengaged from the engagement portion (31c) by an internal pressure of an inner layer bag (22) increased by squeeze-deforming a body of an outer layer bottle (21). The outlet passage is closed with the plug (34) engaged with the engagement portion (31c). After the plug (34) is disengaged from the engagement portion (31c), liquid communication is established between the inside of the inner layer bag (22) and a filter (33).

Abstract: A plug member integrally includes a base portion (35a) attached to a plug holder (31) to be mounted on a mouth portion of a container, a plug (34) engaged with an engagement portion (31c) provided in an outlet passage of the plug holder (31), and a resilient connection portion (35b) resiliently connecting the plug (34) to the base portion (35a). Before the first use, the outlet passage is closed with the plug member. In the first use, the container is squeezed to increase the internal pressure of the container. Thus, the plug (34) is disengaged from the engagement portion (31c) by the internal pressure. The outlet passage is thereafter constantly kept open.

Abstract: A filtering discharge container employing a delaminatable bottle was provided, which reliably prevents a content liquid from leaking out before the first use, and reduces a discharging resistance during the second and subsequent use. An engagement portion (31c) is provided in an outlet passage of a mouth cap (3). A plug (34) is engaged with the engagement portion (31c) in such a manner that the plug (34) can be disengaged from the engagement portion (31c) by an internal pressure of an inner layer bag (22) increased by squeeze-deforming a body of an outer layer bottle (21). The outlet passage is closed with the plug (34) engaged with the engagement portion (31c). After the plug (34) is disengaged from the engagement portion (31c), liquid communication is established between the inside of the inner layer bag (22) and a filter (33).

Abstract: In a filtering dispenser container which includes a plug attached to a mouth portion of a bottle thereof and having a liquid discharge passage, and a filter and a check valve provided in the discharge passage, air lock is prevented, even if the container contains a highly percolative liquid, by preventing a very small amount of liquid percolating the check valve from reaching the filter. In the filtering dispenser container, a dam (14) is provided between the check valve (23) and the filter (25) for retaining a very small amount of the liquid percolating the check valve (23) when the check valve is closed. Thus, the filter (25) is prevented from being wetted with the liquid percolating the closed check valve (23) during storage or delivery of the container before the first use of the container.

Abstract: An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to opthalmological fields, and provide an opthalmological composition having this minimum unit as an effective component. This invention provides an opthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1) (Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH2, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.

Abstract: A filter-equipped container which, particularly in a small-sized eyedrop bottle or the like, is capable of accurate dropping while preventing bubbles from being involved when a contents liquid is to be delivered through a delivery port. To solve such problem, a plug body 12 disposed in the mouth of a bottle 10 is provided with a delivery passage for delivering contents liquid received in the bottle 10, the delivery passage being provided with a filter 25. The filter 25 is composed of a filter film 25a for filtering bacteria to prevent the latter from permeating from upstream to downstream as seen in the direction of delivery, and a contents liquid holding member 25b of porous material that has microscopic pores, disposed upstream of the filter film 25a, the contents liquid holding member 25b being in planar contact with the filter film 25a.

Abstract: In a filtering dispenser container which includes a plug attached to a mouth portion of a bottle thereof and having a liquid discharge passage, and a filter and a check valve provided in the discharge passage, air lock is prevented, even if the container contains a highly percolative liquid, by preventing a very small amount of liquid percolating the check valve from reaching the filter. In the filtering dispenser container, a dam (14) is provided between the check valve (23) and the filter (25) for retaining a very small amount of the liquid percolating the check valve (23) when the check valve is closed. Thus, the filter (25) is prevented from being wetted with the liquid percolating the closed check valve (23) during storage or delivery of the container before the first use of the container.

Abstract: An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to opthalmological fields, and provide an opthalmological composition having this minimum unit as an effective component. This invention provides an opthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1) (Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH2, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.

Abstract: This invention provides a filter-equipped container which, particularly in a small-sized eyedrop bottle or the like, is capable of accurate dropping while preventing bubbles from being involved when a contents liquid is to be delivered through a delivery port. To solve such problem, a plug body 12 disposed in the mouth of a bottle 10 is provided with a delivery passage for delivering contents liquid received in the bottle 10, the delivery passage being provided with a filter 25. The filter 25 is composed of a filter film 25a for filtering bacteria to prevent the latter from permeating from upstream to downstream as seen in the direction of delivery, and a contents liquid holding member 25b of porous material disposed upstream of the filter film 25a, the contents liquid holding member 25b being in planar contact with the filter film 25a.

Abstract: An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to ophthalmological fields, and provide a ophthalmological composition having this minimum unit as an effective component. This invention provides an ophthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1)(Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH2, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.

Abstract: A particularly small eyedropper or the like is provided, which has a construction such that, when a body thereof is squeezed, an introduction hole thereof can be easily closed to compress air in a space between an inner layer and an outer layer thereof even in the absence of a check valve in the introduction hole, and defectiveness of the introduction hole can be easily checked. To this end, a test hole (19) communicating with an introduction hole (17) via a space between an outer layer bottle. (1) and an inner layer bag (16) is provided in an outer layer mouth portion (4). The test hole (19) is closed by the inner layer bag (16) and an inside plug (21) fitted in the mouth portion (4). Further, the introduction hole (17) is provided in a middle portion of a body which is pressed by a finger when the bottle is squeezed. The introduction hole (17) is closed by the finger.

Abstract: The present invention provides a discharging container whose main part is a squeeze-bottle adapted for use as eyedroppers and transparent to such a degree as required. This container has to perfectly shut off ambient air and bacteria not to flowing into a liquid content of the container so as to keep it sterilized even after unsealed for use. The discharging container has a laminated bottle 2, and a stopper 3 attached to a finish 2a of the laminated bottle, the bottle being composed of an outer layer 21 and an inner layer 22 delaminating from the outer layer 21. A vent hole 4 is formed in the outer layer so as to introduce ambient air in between the outer and inner layers 21, 22. A discharging passage 10 is formed in the stopper 3 so as to exude through it a liquid content inside the inner layer 22, and the stopper further has a check valve 8 and a filter 7 disposed on the downstream side of the valve.

Abstract: The present invention provides a discharging container whose main part is a squeeze-bottle adapted for use as eyedroppers and transparent to such a degree as required. This container has to perfectly shut off ambient air and bacteria not to flowing into a liquid content of the container so as to keep it sterilized even after unsealed for use.