Abstract: It is an object to provide a device for estimating a plurality of mental/nervous system diseases by the voice analysis, the device being capable of estimating either major depression or bipolar disorder. Furthermore, there are provided an estimation device including an extraction means for extracting an acoustic feature amount that is not affected by a location where voices are acquired, and a method for operating the estimation device.

Abstract: Provided is a pathological condition analysis system using voice, the pathological condition analysis system allowing anyone to perform measurement and estimate a disease anywhere, in a short time, non-invasively, and without being known to others. A pathological condition analysis system according to the present invention analyzes a pathological condition of a subject, and includes: an input means that acquires voice data of the subject; an estimation means that estimates a disease of the subject based on a voice feature amount extracted from the voice data acquired by the input means; and a display means that displays an estimation result by the estimation means, in which the voice feature amount includes the intensity of voice.

Abstract: It is an object to provide a device for estimating a plurality of mental/nervous system diseases by the voice analysis, the device being capable of estimating either major depression or bipolar disorder. Furthermore, there are provided an estimation device including an extraction means for extracting an acoustic feature amount that is not affected by a location where voices are acquired, and a method for operating the estimation device.

Abstract: There are provided an estimation system, an estimation program and an estimation method through which voice spoken by a subject is estimated, a disease from which the subject is suffering is distinguished and estimated, aggravation of the disease is prevented, and patients are able to receive appropriate treatment based on accurate distinguishing of the disease.

Abstract: A compounds represented by the formula ##STR1## wherein X represents a fluorine atom,W represents an oxygen atom, sulfur atom or group --OCH.sub.2 --,Z.sup.1 and Z .sup.2 each represent a nitrogen atom or group CH, but when Z.sup.1 is a nitrogen atom, Z.sup.2 represents a nitrogen atom or group CH and when Z.sup.1 is a group CH, Z.sup.2 represents a nitrogen atom,R.sup.1 and R.sup.2 each independently represent either a hydrogen atom, halogen atom or mono- or dilower alkyl-substituted amino, or a lower alkyl, lower alkoxy or lower alkylthio each of which may be substituted with a halogen atom,R.sup.3 and R.sup.4 form together with the carbon atoms to which they bind respectively a 5- to 8-membered carbon ring.