Patents by Inventor Yosef Ben

Yosef Ben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Encapsulated amorphous calcium carbonate compositions
    Patent number: 12714726
    Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.
    Type: Grant
    Filed: August 16, 2022
    Date of Patent: August 25, 2026
    Assignee: AMORPHICAL LTD.
    Inventors: Ali Abo Riziq, Sharon Hershkovitz, Yosef Ben, Yigal Blum
  • STABILIZED AMORPHOUS CALCIUM CARBONATE FOR TREATMENT OF NEUROLOGICAL, MUSCULAR AND INFERTILITY DISEASES OR CONDITIONS
    Publication number: 20260240902
    Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.
    Type: Application
    Filed: April 13, 2026
    Publication date: August 20, 2026
    Inventors: Yosef Ben, Abraham Shahar, Amir Arav
  • Stabilized amorphous calcium carbonate for treatment of neurological, muscular and infertility diseases or conditions
    Patent number: 12629390
    Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.
    Type: Grant
    Filed: November 29, 2021
    Date of Patent: May 19, 2026
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Abraham Shahar, Amir Arav
  • AMORPHOUS CALCIUM CARBONATE STABILIZED WITH POLYPHOSPHATES OR BISPHOSPHONATES
    Publication number: 20250017957
    Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.
    Type: Application
    Filed: September 30, 2024
    Publication date: January 16, 2025
    Inventors: Yosef Ben, Yigal Dov Blum, Hagay Moshe, Ben Ashkenazi
  • Compositions of amorphous calcium carbonate for inhalation, sublingual or buccal administration
    Patent number: 12121538
    Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Kits for preparing suspension compositions of the present invention are provided as well.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: October 22, 2024
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Yigal Dov Blum
  • Amorphous calcium carbonate stabilized with polyphosphates or bisphosphonates
    Patent number: 12115184
    Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: October 15, 2024
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Yigal Dov Blum, Hagay Moshe, Ben Ashkenazi
  • Stabilized amorphous calcium carbonate as a supplement for cell culture media
    Patent number: 12060573
    Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: August 13, 2024
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Abraham Shahar, Amir Arav
  • STABILIZED AMORPHOUS CALCIUM CARBONATE AS A SUPPLEMENT FOR CELL CULTURE MEDIA
    Publication number: 20230365935
    Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro and particularly in microgravity.
    Type: Application
    Filed: May 23, 2023
    Publication date: November 16, 2023
    Inventors: Yosef Ben, Yigal Dov Blum, Sara NEUMAN, Orit ECKER
  • NON-AQUEOUS LIQUID AND SEMI-SOLID FORMULATIONS OF AMORPHOUS CALCIUM CARBONATE
    Publication number: 20230181627
    Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.
    Type: Application
    Filed: February 7, 2023
    Publication date: June 15, 2023
    Inventors: Yigal Blum, Yosef Ben, Sharon Hershkovitz
  • Non-aqueous liquid and semi-solid formulations of amorphous calcium carbonate
    Patent number: 11602542
    Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: March 14, 2023
    Assignee: AMORPHICAL LTD.
    Inventors: Yigal Blum, Yosef Ben, Sharon Hershkovitz
  • ENCAPSULATED AMORPHOUS CALCIUM CARBONATE COMPOSITIONS
    Publication number: 20230049778
    Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.
    Type: Application
    Filed: August 16, 2022
    Publication date: February 16, 2023
    Inventors: Ali Abo Riziq, Sharon Hershkovitz, Yosef Ben, Yigal Blum
  • Encapsulated amorphous calcium carbonate compositions
    Patent number: 11446327
    Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 20, 2022
    Assignee: AMORPHICAL LTD.
    Inventors: Ali Abo Riziq, Sharon Hershkovitz, Yosef Ben, Yigal Blum
  • STABILIZED AMORPHOUS CALCIUM CARBONATE FOR TREATMENT OF NEUROLOGICAL, MUSCULAR AND INFERTILITY DISEASES OR CONDITIONS
    Publication number: 20220152094
    Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.
    Type: Application
    Filed: November 29, 2021
    Publication date: May 19, 2022
    Inventors: Yosef Ben, Abraham Shahar, Amir Arav
  • Stabilized amorphous calcium carbonate for treatment of neurological, muscular and infertility diseases or conditions
    Patent number: 11207347
    Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: December 28, 2021
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Abraham Shahar, Amir Arav
  • AMORPHOUS CALCIUM CARBONATE STABILIZED WITH POLYPHOSPHATES OR BISPHOSPHONATES
    Publication number: 20210308178
    Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.
    Type: Application
    Filed: June 9, 2021
    Publication date: October 7, 2021
    Inventors: Yosef Ben, Yigal Dov Blum, Hagay Moshe, Ben Ashkenazi
  • AMORPHOUS CALCIUM CARBONATE FOR TREATING A LEUKEMIA
    Publication number: 20210299165
    Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.
    Type: Application
    Filed: June 14, 2021
    Publication date: September 30, 2021
    Inventor: Yosef Ben
  • COMPOSITIONS OF AMORPHOUS CALCIUM CARBONATE FOR INHALATION, SUBLINGUAL OR BUCCAL ADMINISTRATION
    Publication number: 20210260103
    Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Kits for preparing suspension compositions of the present invention are provided as well.
    Type: Application
    Filed: May 13, 2021
    Publication date: August 26, 2021
    Inventors: Yosef Ben, Yigal Dov Blum
  • Amorphous calcium carbonate stabilized with polyphosphates or bisphosphonates
    Patent number: 11052107
    Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((?( (?) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 6, 2021
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Yigal Dov Blum, Hagay Moshe, Ben Ashkenazi
  • Amorphous calcium carbonate for treating a leukemia
    Patent number: 11052108
    Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: July 6, 2021
    Assignee: AMORPHICAL LTD.
    Inventor: Yosef Ben
  • Compositions of amorphous calcium carbonate for inhalation, sublingual or buccal administration
    Patent number: 11033576
    Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: June 15, 2021
    Assignee: AMORPHICAL LTD.
    Inventors: Yosef Ben, Yigal Dov Blum