Patents by Inventor Yosef Levy

Yosef Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF GENERATING MESENCHYMAL STEM CELLS WHICH SECRETE NEUROTROPHIC FACTORS
    Publication number: 20210338739
    Abstract: A method of generating MSCs which secrete neurotrophic factors (NTFs) comprising incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 4, 2021
    Applicant: BrainStorm Cell Therapeutics Ltd.
    Inventors: Yael GOTHELF, Yosef LEVY, Alex BURSHTEIN
  • Populations of mesenchymal stem cells that secrete neurotrophic factors
    Patent number: 10564149
    Abstract: A method of qualifying whether a cell population is a suitable therapeutic is disclosed. The method comprises: (a) incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP for at least two days to obtain a population of differentiated MSCs; and (b) analyzing the expression of CD49 a in the differentiated MSC population, wherein an amount of CD49 a above a predetermined level indicative of the cell population being suitable as a therapeutic.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: February 18, 2020
    Assignee: BrainStorm Cell Therapeutics Ltd.
    Inventors: Yael Gothelf, Yosef Levy
  • METHODS OF GENERATING MESENCHYMAL STEM CELLS WHICH SECRETE NEUROTROPHIC FACTORS
    Publication number: 20180296607
    Abstract: A method of generating MSCs which secrete neurotrophic factors (NTFs) comprising incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 18, 2018
    Applicant: BrainStorm Cell Therapeutics Ltd.
    Inventors: Yael GOTHELF, Yosef LEVY, Alex BURSHTEIN
  • Methods of generating mesenchymal stem cells which secrete neurotrophic factors
    Patent number: 10046010
    Abstract: A method of generating MSCs which secrete neurotrophic factors (NTFs) comprising incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP.
    Type: Grant
    Filed: August 4, 2013
    Date of Patent: August 14, 2018
    Assignee: BrainStorm Cell Therapeutics Ltd.
    Inventors: Yael Gothelf, Yosef Levy, Alex Burshtein
  • METHOD OF QUALIFYING CELLS
    Publication number: 20160334392
    Abstract: A method of qualifying whether a cell population is a suitable therapeutic is disclosed. The method comprises: (a) incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP for at least two days to obtain a population of differentiated MSCs; and (b) analyzing the expression of CD49a in the differentiated MSC population, wherein an amount of CD49a above a predetermined level indicative of the cell population being suitable as a therapeutic.
    Type: Application
    Filed: February 11, 2015
    Publication date: November 17, 2016
    Inventors: Yael GOTHELF, Yosef LEVY
  • METHODS OF GENERATING MESENCHYMAL STEM CELLS WHICH SECRETE NEUROTROPHIC FACTORS
    Publication number: 20150209389
    Abstract: A method of generating MSCs which secrete neurotrophic factors (NTFs) comprising incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP.
    Type: Application
    Filed: August 4, 2013
    Publication date: July 30, 2015
    Inventors: Yael Gothelf, Yosef Levy, Alex Burshtein
  • METHODS, NUCLEIC ACID CONSTRUCTS AND CELLS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20130236964
    Abstract: A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.
    Type: Application
    Filed: March 4, 2013
    Publication date: September 12, 2013
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Eldad MELAMED, Daniel Offen, Yosef Levy, Pnina Green
  • Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
    Publication number: 20050265983
    Abstract: A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.
    Type: Application
    Filed: May 17, 2005
    Publication date: December 1, 2005
    Inventors: Eldad Melamed, Daniel Offen, Yosef Levy, Pnina Green