Patents by Inventor Yosef Refaeli

Yosef Refaeli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies and processes for preparing the same
    Patent number: 11667695
    Abstract: Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: June 6, 2023
    Assignee: Taiga Biotechnologies, Inc.
    Inventors: Yosef Refaeli, Brian Turner
  • PTD-SMAD7 THERAPEUTICS
    Publication number: 20220370560
    Abstract: The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.
    Type: Application
    Filed: April 22, 2022
    Publication date: November 24, 2022
    Inventors: Xiao-Jing Wang, Qinghong Zhang, Yosef Refaeli
  • MODULATORS OF MYC, METHODS OF USING THE SAME, AND METHODS OF IDENTIFYING AGENTS THAT MODULATE MYC
    Publication number: 20220362377
    Abstract: Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.
    Type: Application
    Filed: May 20, 2022
    Publication date: November 17, 2022
    Applicant: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Yosef REFAELI, Brian Curtis TURNER
  • COMPOSITIONS AND METHODS FOR TREATING T CELL EXHAUSTION
    Publication number: 20220233595
    Abstract: Provided herein are compositions and methods for treating T cell exhaustion in a subject, by administering a PTD-MYC fusion protein (e.g., an HIV TAT-MYC fusion protein) or immune cells treated with a PTD-MYC fusion protein. Kits for use in practicing the methods are also provided herein.
    Type: Application
    Filed: May 13, 2020
    Publication date: July 28, 2022
    Applicant: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Yosef REFAELI, Brian C. Turner, Thomas R. PAYNE
  • Compositions and methods for modulating immune cells
    Patent number: 11369678
    Abstract: Disclosed herein are methods of modulation of the viability of a cell using fusion proteins comprising a transporter peptide sequence and a MYC polypeptide. Further disclosed herein are methods of modulating an immune response using the fusion proteins. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: June 28, 2022
    Assignee: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Yosef Refaeli, Brian Curtis Turner
  • CONDITIONALLY IMMORTALIZED LONG-TERM STEM CELLS AND METHODS OF MAKING AND USING SUCH CELLS
    Publication number: 20220145253
    Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Applicants: NATIONAL JEWISH HEALTH, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: John C. CAMBIER, Yosef REFAELI, Sara Ann JOHNSON, Brian Curtis TURNER
  • COMPOSITIONS AND METHODS FOR THE CRYOPRESERVATION OF IMMUNE CELLS
    Publication number: 20220142149
    Abstract: Provided herein are compositions and methods for the cryopreservation of immune cells, such as peripheral blood mononuclear cells (PBMCs) by pre-treating the cells with a PTD-MYC fusion protein (e.g., an HIV TAT-MYC fusion protein) prior to freezing. Kits for practicing the methods are also provided herein.
    Type: Application
    Filed: April 7, 2020
    Publication date: May 12, 2022
    Inventors: Yosef REFAELI, Brian C. TURNER, Thomas R. PAYNE
  • NANOPARTICLE FORMULATIONS
    Publication number: 20220096545
    Abstract: This present disclosure relates to methods and compositions comprising biologically active nanoparticle formulations of MYC protein. Provided are methods of making the nanoparticle formulations and methods of using the nanoparticle formulations for treatment.
    Type: Application
    Filed: July 27, 2021
    Publication date: March 31, 2022
    Inventors: Brian Curtis TURNER, Yosef REFAELI, Gregory Alan BIRD
  • Nanoparticle formulations
    Patent number: 11116796
    Abstract: This present disclosure relates to methods and compositions comprising biologically active nanoparticle formulations of MYC protein. Provided are methods of making the nanoparticle formulations and methods of using the nanoparticle formulations for treatment.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: September 14, 2021
    Assignee: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Brian Curtis Turner, Yosef Refaeli, Gregory Alan Bird
  • ENHANCED RECONSTITUTION AND AUTORECONSTITUTION OF THE HEMATOPOIETIC COMPARTMENT
    Publication number: 20210177907
    Abstract: The present disclosure relates to the acceleration of hematopoietic compartment reconstitution in a subject in need of hematopoietic stem cell transplantation by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein in combination with hematopoietic stem cell transplantation and to the enhancement of hematopoietic compartment autoreconstitution in a subject in need thereof by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 17, 2021
    Inventors: Brian C. TURNER, Yosef REFAELI, Gregory Alan BIRD
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA
    Publication number: 20210121550
    Abstract: Provided herein are methods and compositions for the treatment of melanoma using anti-tumor immune cells treated with a PTD-MYC fusion protein (e.g., an HIV TAT-MYC fusion protein).
    Type: Application
    Filed: November 9, 2020
    Publication date: April 29, 2021
    Inventors: Yosef REFAELI, Brian C. TURNER, Gregory Alan BIRD
  • Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
    Patent number: 10953048
    Abstract: The present disclosure relates to the acceleration of hematopoietic compartment reconstitution in a subject in need of hematopoietic stem cell transplantation by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein in combination with hematopoietic stem cell transplantation and to the enhancement of hematopoietic compartment autoreconstitution in a subject in need thereof by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: March 23, 2021
    Assignee: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Brian C. Turner, Yosef Refaeli, Gregory Alan Bird
  • PRODUCTION AND USE OF RED BLOOD CELLS
    Publication number: 20210052655
    Abstract: The present disclosure relates to the production of red blood cells from hematopoietic stem cells, by differentiating such cells in the presence of a protein that induces cell survival and proliferation.
    Type: Application
    Filed: September 1, 2020
    Publication date: February 25, 2021
    Inventors: Brian C. TURNER, Yosef REFAELI, Gregory A. BIRD
  • Methods and compositions for the treatment of melanoma
    Patent number: 10864259
    Abstract: Provided herein are methods and compositions for the treatment of melanoma using anti-tumor immune cells treated with a PTD-MYC fusion protein (e.g., an HIV TAT-MYC fusion protein).
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: December 15, 2020
    Assignee: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Yosef Refaeli, Brian C. Turner, Gregory Alan Bird
  • CONDITIONALLY IMMORTALIZED LONG-TERM STEM CELLS AND METHODS OF MAKING AND USING SUCH CELLS
    Publication number: 20200308545
    Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 1, 2020
    Inventors: John C. CAMBIER, Yosef REFAELI, Sara Ann JOHNSON, Brian Curtis TURNER
  • Production and use of red blood cells
    Patent number: 10786534
    Abstract: The present disclosure relates to the production of red blood cells from hematopoietic stem cells, by differentiating such cells in the presence of a protein that induces cell survival and proliferation.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: September 29, 2020
    Assignee: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Brian C. Turner, Yosef Refaeli, Gregory A. Bird
  • Conditionally immortalized long-term stem cells and methods of making and using such cells
    Patent number: 10760055
    Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: September 1, 2020
    Assignees: NATIONAL JEWISH HEALTH, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: John C. Cambier, Yosef Refaeli, Sara Ann Johnson, Brian Curtis Turner
  • NANOPARTICLE FORMULATIONS
    Publication number: 20200222464
    Abstract: This present disclosure relates to methods and compositions comprising biologically active nanoparticle formulations of MYC protein. Provided are methods of making the nanoparticle formulations and methods of using the nanoparticle formulations for treatment.
    Type: Application
    Filed: January 14, 2020
    Publication date: July 16, 2020
    Inventors: Brian Curtis TURNER, Yosef REFAELI, Gregory Alan BIRD
  • MODULATORS OF MYC, METHODS OF USING THE SAME, AND METHODS OF IDENTIFYING AGENTS THAT MODULATE MYC
    Publication number: 20200215188
    Abstract: Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.
    Type: Application
    Filed: January 14, 2020
    Publication date: July 9, 2020
    Inventors: Yosef REFAELI, Brian Curtis TURNER
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
    Publication number: 20200155600
    Abstract: Provided herein are methods for adoptive cell transfer for the treatment of cancer, comprising administering a therapeutically effective amount of immune cells having antitumor activity to a subject, wherein the immune cells are contacted with a protein transduction domain (PTD)-MYC fusion polypeptide prior to administration to the subject. In some embodiments, the PTD-MYC fusion polypeptide comprises: (i) an HIV TAT protein transduction domain; and (ii) a MYC polypeptide sequence.
    Type: Application
    Filed: August 1, 2018
    Publication date: May 21, 2020
    Inventors: Yosef REFAELI, Brian C. TURNER, Gregory Alan BIRD