Patents by Inventor Yosef Shiloh

Yosef Shiloh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ataxia-telangiectasia gene and its genomic organization
    Publication number: 20030118991
    Abstract: A gene, designated ATM, mutations of which cause ataxia-telangiectasia (A-T), that has been purified, isolated, and sequenced as well as mutations of the gene and the genomic organization of the gene. A method for identifying carriers of the defective A-T gene in a population and effective A-T gene products. The detection of A-T mutation carriers for use in determining cancer predisposition and radiation sensitivity so that carrier exposure to radiation can be properly monitored and avoided.
    Type: Application
    Filed: April 3, 2001
    Publication date: June 26, 2003
    Inventor: Yosef Shiloh
  • Ataxia-telangiectasia gene and its genomic organization
    Patent number: 6265158
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia, its genomic organization, methods for the detection of the defective gene, the purified polypeptide encoded by the defective gene, and antibodies recognizing the defective protein.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: July 24, 2001
    Assignee: Ramot-University Authority for Applied Research and Industrial Development
    Inventor: Yosef Shiloh
  • Ataxia-telangiectasia gene
    Patent number: 6211336
    Abstract: There is provided a purified amino acid sequence selected from the group of Sequence ID No.: 3 and analogs thereof and mutations of Sequence ID No.: 3 which cause ataxia-telangiectasia. Also provided is a purified amino acid sequence as set forth in Sequence ID No.: 3 and analogs thereof.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: April 3, 2001
    Assignees: The United States of America as represented by the Department of Health and Human Services, Ramot University Authority for Applied Research and Industrial Dev.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis Collins
  • Mutated forms of the ataxia-telangiectasia gene and method to screen for a partial A-T phenotype
    Patent number: 6200749
    Abstract: A purified and isolated gene, designated ATM, is described mutations of which cause ataxia-telangiectasia and its genomic organization.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: March 13, 2001
    Assignee: Ramot-University Authority for Applied Research and Industrial Development Ltd.
    Inventor: Yosef Shiloh
  • Ataxia-telangiectasia gene and its genomic organization
    Patent number: 5858661
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia and its genomic organization is disclosed. Methods and a kit for the detection of carriers of mutations of the ATM gene are provided by analysis of nucleic acids isolated from patients including in situ hybridization, Northern blotting and reverse transcriptase--polymerase chain reaction, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification and DNA-chip analysis.
    Type: Grant
    Filed: April 8, 1996
    Date of Patent: January 12, 1999
    Assignee: RAMOT-University Authority for Applied Research and Industrial Development
    Inventor: Yosef Shiloh
  • cDNAs associated with ataxia-telangiectasia
    Patent number: 5777093
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia.
    Type: Grant
    Filed: July 28, 1995
    Date of Patent: July 7, 1998
    Assignee: RAMOT-University Authority for Applied Research & Industrial Development Ltd.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis S. Collins
  • Ataxia-telangiectasai gene
    Patent number: 5756288
    Abstract: A purified, isolated and cloned DNA sequence consisting essentially of a DNA sequence (SEQ ID No:1) partially encoding the gene, designated ATM, mutations in which cause ataxia-telangiectasia and a method for detecting carriers of the defective gene which causes ataxia-telangiectasia. The method includes isolating genetic material from a cell sample of a subject and the genetic material with molecular probes complementary to SEQ ID No:1 and point mutations, deletions or insertions thereof in order to detect carriers of the mutant gene.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: May 26, 1998
    Assignee: Ramot-University of Authority for Applied Research and Industrial Dev. Ltd.
    Inventor: Yosef Shiloh
  • Mutated proteins associated with ataxia-telangiectasia
    Patent number: 5728807
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: March 17, 1998
    Assignee: Ramot-University Authority For Applied Research and Industrial Development, Ltd.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis S. Collins