Abstract: A coolant supply device includes a coolant tank having first and second coolant reservoirs arranged in parallel with a predetermined space therebetween and a communicating part arranged between the first and second coolant reservoirs to allow them to communicate with each other, and formed to have a U-shaped overall shape. The coolant supply device further includes pumps pumping up coolant from the second coolant reservoir and supplying the coolant to predetermined destinations. The coolant supplied by the pumps is returned to the first coolant reservoir and flows into the second coolant reservoir through the communicating part. The first coolant reservoir has a first agitating nozzle body disposed therein for discharging coolant to assist a flow of coolant flowing toward the communicating part, and the second coolant reservoir has a second agitating nozzle body disposed therein for discharging coolant to assist a flow of coolant flowing therein from the communicating part.

Abstract: A method of manufacturing a shoe insole includes an upper cover layer and a lower cover layer conforming in shape to the inner bottom of the shoe, and an insole body retained between the upper cover layer and the lower cover layer, taking a foot sole form to which pads are applied to selected regions of a sole taking a foot sole form; manufacturing an insole frame having a shape conforming to a three-dimensional shape of the foot sole form and applying insole pads to an upper surface of the insole frame, based on positions of marks of the test pads of the foot sole form to which the pads are applied, wherein the insole body includes the insole frame to which the insole pads are applied.

Abstract: A coolant supply device includes a coolant tank having first and second coolant reservoirs arranged in parallel with a predetermined space therebetween and a communicating part arranged between the first and second coolant reservoirs to allow them to communicate with each other, and formed to have a U-shaped overall shape. The coolant supply device further includes pumps pumping up coolant from the second coolant reservoir and supplying the coolant to predetermined destinations. The coolant supplied by the pumps is returned to the first coolant reservoir and flows into the second coolant reservoir through the communicating part. The first coolant reservoir has a first agitating nozzle body disposed therein for discharging coolant to assist a flow of coolant flowing toward the communicating part, and the second coolant reservoir has a second agitating nozzle body disposed therein for discharging coolant to assist a flow of coolant flowing therein from the communicating part.

Abstract: A method of manufacturing a shoe insole, comprising including an upper cover layer and a lower cover layer conforming in shape to the inner bottom of the shoe, and an insole body retained between the upper cover layer and the lower cover layer, taking a foot sole form to which pads are applied to selected regions of a sole; taking a foot sole form; manufacturing an insole frame having a shape conforming to a three-dimensional shape of the foot sole form; and applying insole pads to an upper surface of the insole frame, based on positions of marks of the test pads of the foot sole form to which the pads are applied, wherein the insole body includes the insole frame to which the insole pads are applied.

Abstract: A horizontal machining center includes: a table driven in first and second directions (directions indicated by arrows 530p and 530q, respectively) allowing the table to approach and move away from a spindle, respectively; a magazine having a plurality of tool gripping claws; and a coupling mechanism for coupling the table and the magazine together and moving the magazine in one of the first and second directions when the table is driven in the other of the first and second directions. When a tool attached to the spindle is removed from the spindle, the table is driven in the first direction, and when a tool accommodated by the magazine is attached to the spindle, the table is driven in the second direction. A horizontal machining center having a simple structure and prevented from having a bulky structure can thus be accomplished.

Abstract: [PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.

Abstract: [PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.

Abstract: [Problems] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [Means for Solving Problems] A novel soluble polypeptide protein.

Abstract: A horizontal machining center includes: a table driven in first and second directions (directions indicated by arrows 530p and 530q, respectively) allowing the table to approach and move away from a spindle, respectively; a magazine having a plurality of tool gripping claws; and a coupling mechanism for coupling the table and the magazine together and moving the magazine in one of the first and second directions when the table is driven in the other of the first and second directions. When a tool attached to the spindle is removed from the spindle, the table is driven in the first direction, and when a tool accommodated by the magazine is attached to the spindle, the table is driven in the second direction. A horizontal machining center having a simple structure and prevented from having a bulky structure can thus be accomplished.

Abstract: An object of the present invention is to provide a preventive drug and a therapeutic drug for diseases caused by abnormal bone metabolism, especially osteoporosis, which is more effective than conventional drugs. Combined use of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or a salt thereof; and at least one compound selected from the group consisting of etidronic acid, clodronic acid, pamidronic acid, tiludronic acid, risedronic acid, minodronic acid, ibandronic acid, zoledronic acid, and salts thereof can exert higher bone resorption inhibitory effect and provide a preventive effect and a therapeutic effect for diseases caused by abnormal bone metabolism, especially osteoporosis as compared with administration of the respective agents respectively.

Abstract: A method enabling a destroyed part of a joint or joint cartilage to be extracted accurately and at a high speed with a good repeatability and enabling quantitative and simple 3D analysis of the joint and the destroyed part, that is, a method of 3D image processing comprising filling in a medullary cavity region, comprised of a hollow region inside a joint, of a digitalized image of a cross-section of the examined joint using the Expansion and Shrinkage method, performing 3D labeling by a 3D image obtained by stacking digitalized images of cross-sections of the examined joint generated at a step of extracting a contour of the cross-sectional image of the joint or digitalized images of cross-sections of the examined joint not pre-processed, and defining the joint image to be evaluated.

Abstract: [PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.

Abstract: [Problems] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [Means for Solving Problems] A novel soluble polypeptide protein.

Abstract: As a method of promoting natural HDR and curing disc herniation an apparatus is provided for shortening the time period of HDR, by ultrasonic irradiation. The apparatus is equipped with at least one ultrasonic transducer, an ultrasonic oscillator and mount means for mounting the ultrasonic transducer to an bone joint site, and is means for irradiating ultrasonic waves of 1.3 to 2 MHz in frequency, 100 to 1,000 Hz in repetition frequency, 10 to 2000 ?s in burst width and 100 mW/cm2 or less in power (SATA: Spatial Average-Temporal Average).

Abstract: This invention relates to a bone measurement method for measuring a bone shape, structure and architecture on the basis of the tomographic images of a test bone or joint, in more detail, to a bone measurement method characterized by having a template image extraction step for obtaining a wholly continued template image of a bone inner portion surrounded by a cortical bone from the binary image of a test bone cross section, and separating a cortical bone and a cancellous bone by the product of said template image and said binary image, as a bone measurement method which enables the automatic, high-speed and repeatable separation of a cortical bone and a cancellous bone on the basis of the binary image of a test bone or joint cross section and by which a separated three-dimensional image of the cortical bone portion and the cancellous bone portion is obtained as the bases for a non-invasive analyses of three-dimensional bone structure, bone strength, and the like.

Abstract: A method enabling a destroyed part of a joint or joint cartilage to be extracted accurately and at a high speed with a good repeatability and enabling quantitative and simple 3D analysis of the joint and the destroyed part, that is, a method of 3D image processing comprising filling in a medullary cavity region, comprised of a hollow region inside a joint, of a digitalized image of a cross-section of the examined joint using the Expansion and Shrinkage method, performing 3D labeling by a 3D image obtained by stacking digitalized images of cross-sections of the examined joint generated at a step of extracting a contour of the cross-sectional image of the joint or digitalized images of cross-sections of the examined joint not pre-processed, and defining the joint image to be evaluated.

Abstract: The present invention provides an apparatus and a method for treating joint diseases. In order to lower a matrix metalloprotease (MMP) activity which has been enhanced in accompany with a joint disease such as osteoarthritis or rheumatoid arthritis, and to improve the joint disease, the apparatus lowers the MMP activity at the joint site by applying ultrasonic waves on it. The apparatus is a means provided with at least an ultrasonic transducer, an ultrasonic generator and a means for mounting the ultrasonic transducer on the joint site, and applying ultrasonic waves having a frequency of 1.3 to 2 MHz, a repeating frequency of 100 to 1,000 Hz, a burst width of 10 to 2,000 &mgr;s and an intensity of 100 mW/cm2 or less (SATA: Spatial Average-Temporal Average).

Abstract: A lactone compound, useful as an osteogenetic accelerator, having the formula (I): ##STR1## wherein n is zero or 1 and m is zero or 1, provided that both n and m are not zero at the same time, or a stereoisomer thereof at the 23- and/or 25-positions or any mixture thereof and a production process thereof.