Patents by Inventor Yoshie Nagahashi

Yoshie Nagahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method Of Producing Compound Having Anti-Hcv Activity
    Publication number: 20110098477
    Abstract: There is provided a convenient and inexpensive method of producing a compound which has a high activity of inhibiting replication of hepatitis C virus (HCV) and is useful for preventing and treating a liver disease caused by HCV infection.
    Type: Application
    Filed: June 27, 2006
    Publication date: April 28, 2011
    Inventors: Masahiro Aoki, Yoshie Nagahashi, Hideyuki Kato, Tatsuya Ito, Miyako Masubuchi, Toru Okuda
  • Gene encoding vitamin bphosphate phosphatase and use thereof
    Patent number: 7598066
    Abstract: Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO:10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: October 6, 2009
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Yoshie Nagahashi, Masaaki Tazoe
  • Gene encoding vitamin b6 phosphate phosphatase and use thereof
    Publication number: 20060263862
    Abstract: Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO: 10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).
    Type: Application
    Filed: September 23, 2003
    Publication date: November 23, 2006
    Applicant: DSM IP ASSETS B.V.
    Inventors: Tatsuo Hoshino, Yoshie Nagahashi, Masaaki Tazoe
  • Microorganism and process for preparing vitamin b6
    Publication number: 20060127992
    Abstract: Disclosed is a recombinant microorganism of the genus Sinorhizobium which is transformed with a vector containing pyridoxol 5?-phophate synthase gene and D-erythrose 4-phosphate dehydrogenase gene, and being capable of producing vitamin B6.
    Type: Application
    Filed: September 16, 2003
    Publication date: June 15, 2006
    Inventors: Tatsuo Hoshino, Keiko Ichikawa, Yoshie Nagahashi, Masaaki Tazoe
  • Biotin biosynthetic genes having biotin synthase activity
    Patent number: 6955906
    Abstract: The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: October 18, 2005
    Assignee: DSM Nutritional Products, Inc.
    Inventors: Yasuhiro Furuichi, Tatsuo Hoshino, Hitoshi Kimura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Biotin biosynthetic genes
    Publication number: 20040137584
    Abstract: The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 15, 2004
    Applicant: ROCHE VITAMINS INC.
    Inventors: Yasuhiro Furuichi, Tatsuo Hoshino, Hitoshi Kimura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Biotin biosynthetic genes
    Patent number: 6723544
    Abstract: The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: April 20, 2004
    Assignee: Roche Vitamins, Inc.
    Inventors: Yasuhiro Furuichi, Tatsuo Hoshino, Hitoshi Kimura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Production of biotin
    Publication number: 20040063166
    Abstract: The present invention provides processes for making biotin from desthiobiotin by either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product and/or nifS gene product and isolating the biotin or cultivating a microorganism transformed with DNA encoding the bioB gene product, nifU gene product and nifS gene product and isolating the biotin.
    Type: Application
    Filed: May 15, 2003
    Publication date: April 1, 2004
    Applicant: ROCHE VITAMINS, INC.
    Inventors: Tatsuo Hoshino, Akira Asakura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Production of biotin
    Publication number: 20030096382
    Abstract: The present invention provides process for making biotin from desthiobiotin either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product and/or nifS gene product and isolating the biotin or cultivating a microorganism transformed with DNA encoding the bioB gene product, nifU gene product and nifS gene product and isolating the biotin.
    Type: Application
    Filed: March 22, 2001
    Publication date: May 22, 2003
    Applicant: ROCHE VITAMINS INC.
    Inventors: Tatsuo Hoshino, Akira Asakura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Biotin biosynthetic genes
    Publication number: 20020123109
    Abstract: The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
    Type: Application
    Filed: December 27, 2001
    Publication date: September 5, 2002
    Applicant: ROCHE VITAMINS INC.
    Inventors: Yasuhiro Furuichi, Tatsuo Hoshino, Hitoshi Kimura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Biotin biosynthetic genes
    Patent number: 6365388
    Abstract: The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: April 2, 2002
    Assignee: Roche Vitamins, Inc.
    Inventors: Yasuhiro Furuichi, Tatsuo Hoshino, Hitoshi Kimura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Production of biotin
    Patent number: 6361978
    Abstract: The present invention provides processes for making biotin from desthiobiotin by either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product and/or nifS gene product and isolating the biotin or cultivating a microorganism transformed with DNA encoding the bioB gene product, nifU gene product and nifS gene product and isolating the biotin.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: March 26, 2002
    Assignee: Roche Vitamins, Inc.
    Inventors: Tatsuo Hoshino, Akira Asakura, Tatsuya Kiyasu, Yoshie Nagahashi
  • Biotin biosynthetic genes
    Patent number: 6117669
    Abstract: The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: September 12, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Yasuhiro Furuichi, Tatsuo Hoshino, Hitoshi Kimura, Tatsuya Kiyasu, Yoshie Nagahashi