Patents by Inventor Yoshifumi Muraki

Yoshifumi Muraki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220249506
    Abstract: To provide a technique for improving the dissolution of meloxicam. A granulated product, including the following components (A), (B), and (C): (A) meloxicam or a salt thereof, or a solvate thereof; (B) one or more basic compounds selected from the group consisting of potassium bicarbonate, sodium bicarbonate, arginine, lysine, magnesium hydroxide, and magnesium oxide; and (C) a water-swellable polymer.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 11, 2022
    Inventors: Ryo CHIBA, Yoshifumi MURAKI
  • Patent number: 7638129
    Abstract: This invention provides for a protein of the TGF-? superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: December 29, 2009
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Shinji Kawai, Michio Kimura, Yoshifumi Muraki, Mieko Katsuura
  • Publication number: 20080318856
    Abstract: This invention provides for a protein of the TGF-? superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
    Type: Application
    Filed: June 6, 2007
    Publication date: December 25, 2008
    Applicant: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Shinji KAWAI, Michio KIMURA, Yoshifumi MURAKI, Mieko KATSUURA
  • Patent number: 7235241
    Abstract: This invention provides for a protein of the TGF-? superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: June 26, 2007
    Assignee: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Shinji Kawai, Michio Kimura, Yoshifumi Muraki, Mieko Katsuura
  • Publication number: 20060019886
    Abstract: This invention provides for a protein of the TGF-? superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
    Type: Application
    Filed: January 6, 2004
    Publication date: January 26, 2006
    Inventors: Shinji Kawai, Michio Kimura, Yoshifumi Muraki, Mieko Katsuura