Patents by Inventor Yoshifumi Yuasa
Yoshifumi Yuasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8252356Abstract: The present invention relates to a flavor composition or fragrance composition which can satisfy diversified requirements for flavored products, as well as to a flavor-improving agent which can improve the quality and release of aroma of a beverage or food. More particularly, the present invention relates to a flavor composition or fragrance composition which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, a flavor- or fragrance-added product, a flavor-improving agent which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, and a beverage or food having an improved flavor. The optically active S-alkyl 2-methylbutanethioate includes S-alkyl(R)-2-methylbutanethioate and S-alkyl(S)-2-methylbutanethioate.Type: GrantFiled: March 22, 2011Date of Patent: August 28, 2012Assignee: Takasago International CorporationInventors: Miharu Ogura, Yoshihiro Yaguchi, Makoto Emura, Toshihiro Takeda, Yoshifumi Yuasa, Shigeyuki Sasaki
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Publication number: 20110171358Abstract: The present invention relates to a flavor composition or fragrance composition which can satisfy diversified requirements for flavored products, as well as to a flavor-improving agent which can improve the quality and release of aroma of a beverage or food. More particularly, the present invention relates to a flavor composition or fragrance composition which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, a flavor- or fragrance-added product, a flavor-improving agent which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, and a beverage or food having an improved flavor. The optically active S-alkyl 2-methylbutanethioate includes S-alkyl(R)-2-methylbutanethioate and S-alkyl(S)-2-methylbutanethioate.Type: ApplicationFiled: March 22, 2011Publication date: July 14, 2011Inventors: Miharu Ogura, Yoshihiro Yaguchi, Makoto Emura, Toshihiro Takeda, Yoshifumi Yuasa, Shigeyuki Sasaki
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Publication number: 20080213451Abstract: The present invention relates to a flavor composition or fragrance composition which can satisfy diversified requirements for flavored products, as well as to a flavor-improving agent which can improve the quality and release of aroma of a beverage or food. More particularly, the present invention relates to a flavor composition or fragrance composition which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, a flavor- or fragrance-added product, a flavor-improving agent which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, and a beverage or food having an improved flavor. The optically active S-alkyl 2-methylbutanethioate includes S-alkyl (R)-2-methylbutanethioate and S-alkyl (S)-2-methylbutanethioate.Type: ApplicationFiled: September 8, 2006Publication date: September 4, 2008Inventors: Miharu Ogura, Yoshihiro Yaguchi, Makoto Emura, Toshihiro Takeda, Yoshifumi Yuasa, Shigeyuki Sasaki
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Publication number: 20050001733Abstract: Herein disclosed is a wireless electric appliance system, comprising an electric appliance having assigned thereto a control code, and a wireless remote control apparatus having assigned thereto an operation code to be matched with the control code. The electric appliance is operably connected with the electric appliance. The electric appliance includes storage means for storing therein the control code; and transmitting means for transmitting a signal including the control code stored in the storage means to the wireless remote control apparatus.Type: ApplicationFiled: December 9, 2003Publication date: January 6, 2005Inventors: Yoichiro Tsuruta, Toshiya Kanamori, Yoshifumi Yuasa
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Patent number: 5959161Abstract: To offer a method of producing useful para-menthane-3,8-diol having the excellent repellent action to harmful living things, including noxious insects, in high purity and high yield, simply, and economically by the use of citronellal as a raw material compound.The above-mentioned problems are resolved by the production method of this invention wherein citronellal is treated with aqueous sulfuric acid solution of 0.02 to 1.0 wt. % in concentration to produce para-menthane-3,8-diol. In case of recovering the produced para-menthane-3,8-diol, a method is preferably adopted, wherein after the reaction product is extracted with an aliphatic hydrocarbon solvent of 5 to 8 in carbon number, the extract is cooled down at temperature higher than the melting point of said aliphatic hydrocarbon solvent and of -10.degree. C. or less to crystallize para-menthane-3,8-diol.Type: GrantFiled: October 27, 1998Date of Patent: September 28, 1999Assignee: Takasago International CorporationInventors: Hiroyuki Kenmochi, Teruyoshi Akiyama, Yoshifumi Yuasa, Toyohiko Kobayashi, Akio Tachikawa
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Patent number: 5945559Abstract: A novel process for producing 3-oxocarboxylic acid esters, which are useful as intermediates in the synthesis of ceramides to be used as a humectant, biodegradable polymers, drugs, etc., at a high purity and a high yield without requiring any troublesome procedure, is disclosed. The process comprises reacting an acetoacetic ester with a calcium compound, a barium compound or a strontium compound in the presence of an organic solvent at a temperature of 10 to 120.degree. C., further reacting the obtained product with a carboxylic acid chloride to thereby acylate it, and then adding thereto an alcohol in an amount 1 to 5 times by mol as much as the calcium compound, barium compound or strontium compound to thereby deacetylate the same.Type: GrantFiled: May 23, 1997Date of Patent: August 31, 1999Assignee: Takasago International CorporationInventors: Tsukasa Sotoguchi, Yoshifumi Yuasa, Akio Tachikawa, Shunichi Harada
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Patent number: 5942629Abstract: A production process for obtaining optically active (3R,1'S)-1-benzyl-3-?(1'-N-methylamino)ethyl!pyrrolidine or (3R,1'S)-3-?(1'-N-methylamino)ethyl!pyrrolidine used as an intermediate for the synthesis of pharmaceutical preparations such as anti-fungal agents in high purity and in high yield using a reduced number of processing steps. The process comprises asymmetrically hydrogenating 3-acetyl-1-benzyl-2-pyrrolidinone in the presence of a complex formed from bidentate phosphine and ruthenium as a catalyst to provide (3S,1'R)-1-benzyl-3-?(1'-hydroxy)ethyl!-2-pyrrolidinone, then reducing with a hydride to provide (3R,1'R)-1-benzyl-3-?(1'-hydroxy)ethyl!pyrrolidine, mesylating or tosylating to provide (3R,1'R)-1-benzyl-3-?(1'-methanesulfonyloxy)ethyl!pyrrolidine or (3R,1'R)-1-benzyl-3-?(1'-p-toluenesulfonyloxy)ethyl!pyrrolidine, and reacting with methylamine to obtain (3R,1'S)-1-benzyl-3-?(1'-N-methylamino)ethyl!pyrrolidine.Type: GrantFiled: November 24, 1997Date of Patent: August 24, 1999Assignee: Takasago International CorporationInventors: Yoshifumi Yuasa, Tsukasa Sotoguchi, Nobuo Seido
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Patent number: 5859249Abstract: Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative. The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.Type: GrantFiled: July 16, 1997Date of Patent: January 12, 1999Assignee: Takasago International CorporationInventors: Nobuo Seido, Takenobu Nishikawa, Tsukasa Sotoguchi, Yoshifumi Yuasa, Takashi Miura, Hidenori Kumobayashi
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Patent number: 5801271Abstract: Disclosed is a 7-(N-substituted amino)-3-oxo-2-phenylheptanoate derivative, 7-(N-substituted amino)-3-hydroxy-2-phenylheptanoate derivative, and 7-(N-substituted amino)-3-benzenesulfonyloxy-2-phenylheptanoate derivative, which are quite important major intermediates for an antidepressant. The 7-(N-substituted amino)-3-oxo-2-phenylheptanoate derivative can be manufactured by condensing an enolate of phenylacetates with a 5-(N-substituted amino) pentanoate derivative.Type: GrantFiled: July 16, 1997Date of Patent: September 1, 1998Assignee: Takasago International CorporationInventors: Nobuo Seido, Takenobu Nishikawa, Tsukasa Sotoguchi, Yoshifumi Yuasa, Takashi Miura, Hidenori Kumobayashi
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Patent number: 5780649Abstract: A process for preparing optically active 3-hydroxy-.gamma.-butyrolactone or optically active 3-hydroxytetrahydrofuran through a short route and by using an easily available and inexpensive starting material and an inexpensive reagent easy to handle is disclosed. The process comprises cyclizing an optically active compound represented by formula (II): ##STR1## wherein Q represents an alkoxycarbonyl group having 1 to 4 carbon atoms or a hydroxymethyl group; X represents a halogen atom; and the asterisk * means an asymmetric carbon atom, under an acidic condition.Type: GrantFiled: September 4, 1996Date of Patent: July 14, 1998Assignee: Takasago International CorporationInventors: Yoshifumi Yuasa, Masao Konno, Noboru Sano
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Patent number: 5599954Abstract: Compounds represented by the following general structural formula (1) and methods for producing the compounds: ##STR1## R.sup.1 represents a group such as benzyloxycarbonyl, R.sup.2 represents a lower alkyl group, R.sup.3 represents a hydrogen atom or a protecting group, each of M.sup.1 and M.sup.2 represents a metal atom, and n represents the atomic valence of M.sup.1. Intermediates for HMG-CoA reductase inhibitors can be prepared safely and easily from these compounds.Type: GrantFiled: January 26, 1996Date of Patent: February 4, 1997Assignee: Takasago International CorporationInventors: Sigeru Mitsuhashi, Tsukasa Sotoguchi, Yoshifumi Yuasa, Hidenori Kumobayashi
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Patent number: 5587510Abstract: The present invention provides a novel 2-aralkyl-3-chloropropionic acid and a process for the preparation thereof. A novel 2-aralkyl-3-chloropropionic acid is represented by the general formula (1): ##STR1## and can be prepared by asymmetrically hydrogenating a (Z)-2-aralkylidene-3-chloropropionic acid represented by the general formula (II): ##STR2## with a complex of a bidentate phosphine with ruthenium as a catalyst in the presence of a tertiary amine.Type: GrantFiled: May 23, 1995Date of Patent: December 24, 1996Assignee: Takasago International CorporationInventors: Masao Konno, Yoshifumi Yuasa
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Patent number: 5581007Abstract: A process for preparing an optically active (2S,3S)-allophenylnorstatin derivative (I) is disclosed, comprising asymmetrically hydrogenating a 4-phenyl-2-halogeno-3-oxobutyric ester (III) in the presence of a ruthenium-phosphine complex to obtain a 4-phenyl-(2S)-halogeno-(3R)-hydroxybutyric ester (IV), epoxidizing the ester (IV) in the presence of a base to obtain a 4-phenyl-(2S,3R)-epoxybutyric ester (V), reacting the ester (V) with a tri(lower alkyl)silylazide or a (lower alkyl)diarylsilylazide in the presence of a Lewis to obtain a (3S)-azido-4-phenyl-(2S)-trisubstituted silyloxybutyric ester (VI), hydrogenolyzing the ester (VI) into a (2S,3S)-allophenylnorstatin derivative (VII), protecting the amino group of the compound (VII), and, if desired, hydrolyzing the compound before or after the amino group protection. Compounds (I) can be obtained at high optical purity safely and in good yield.Type: GrantFiled: March 1, 1996Date of Patent: December 3, 1996Assignee: Takasago International CorporationInventors: Noboru Sayo, Tetsuro Yamasaki, Hidenori Kumobayashi, Yoshifumi Yuasa, Tsukasa Sotoguchi
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Patent number: 5463118Abstract: (2R,3R)-3-N-(L-aspartyl)amino-1-(1-methyl-2-norbornyl)-2-butanol and (2R,3R)-3-N-(L-aspartyl)amino-1-(3-methyl-2-norbornyl)-2-butanol as well as a sweetener comprising the same are disclosed. These compounds, which have excellent sweetness characteristics and are stable in acidic aqueous solutions, are highly useful as a sweetener in various fields.Type: GrantFiled: June 2, 1994Date of Patent: October 31, 1995Assignee: Takasago International CorporationInventors: Yoshifumi Yuasa, Yoshiki Okeda, Akio Tachikawa, Akira Nagakura, Haruki Tsuruta
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Patent number: 5246949Abstract: (A) a diacylated dopamine derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 3 to 7 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, substituted or unsubstituted phenyl group or a substituted or unsubstituted nitrogen-containing heterocyclic group; and R.sup.2 represents a hydrogen atom or a lower alkyl group; or a salt thereof; and(B) one or more compounds selected from lactic acid esters, fatty acid monoglycerides and higher alcohols; optionally together with(C) an unsaturated fatty acid monohydric alcohol ester. This preparation has a sustained effect, a high skin permeability and a low skin irritativeness.Type: GrantFiled: July 8, 1992Date of Patent: September 21, 1993Assignees: Sansho Co., Ltd., Takasago International Corp.Inventors: Mitsuhiro Yoshida, Hiroyuki Fujimori, Yoshio Ishino, Akira Sasaki, Masayoshi Kasai, Keiji Ohmori, Noriko Konita, Yoshifumi Yuasa, Toyohiko Kobayashi