Abstract: A monoclonal antibody is provided which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment thereof. The monoclonal antibody binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15). An antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment are also provided.

Abstract: A liquid crystal composition including liquid crystalline compounds, polymerizable compounds, and dichroic dyes in which the polymerizable compound includes at least one compound represented by Formula (1), R11-MES-Sp11-P11??(1) in Formula (1), R11 is an alkyl group having 1 to 15 carbon atoms; MES is a mesogenic group having at least one ring, and in the ring in MES, at least one hydrogen atom is optionally substituted with -Sp11-P11; Sp11 is a single bond or an alkylene group having 1 to 10 carbon atoms, and in this alkylene group, at least one —CH2— is optionally substituted with —O—, —CO—, —COO—, —OCO—, or —OCOO—, and at least one —(CH2)2— is optionally substituted with —CH?CH— or —C?C—, and in these groups, at least one hydrogen atom is optionally substituted with a polymerizable group; P11 is a polymerizable group or a polar group, or a group having both polymerization and polarity.

Abstract: The purpose of the invention is to control, by using a colorless alignment control monomer, the alignment of liquid crystal molecules of a liquid crystal display element that does not include an alignment film, and to provide a liquid crystal composition with which the colorless alignment control monomer exhibits excellent compatibility. The invention uses a liquid crystal display element that comprises an alignment control monomer including an aromatic ester that undergoes photo-Fries rearrangement by light irradiation, and that employs a liquid crystal composition having a negative dielectric anisotropy. The invention also uses the liquid crystal composition.

Abstract: The purpose of the invention is to control, by using a colorless alignment control monomer, the alignment of liquid crystal molecules of a liquid crystal display element that does not include an alignment film, and to provide a liquid crystal composition with which the colorless alignment control monomer exhibits excellent compatibility. The invention uses a liquid crystal display element that comprises an alignment control monomer including an aromatic ester that undergoes photo-Fries rearrangement by light irradiation, and that employs a liquid crystal composition having a positive dielectric anisotropy. The invention also uses the liquid crystal composition.

Abstract: Provide is a polar compound having high chemical stability, high capability of aligning liquid crystal molecules, high solubility in a liquid crystal composition, and a large voltage holding ratio when the compound is used in a liquid crystal display device. A compound represented by formula (1) is applied. For example, in formula (1), P1 is any one of formulas (1b) to (1i), Sp is a single bond, Z is —COO—, and A is 1,4-phenylene.

Abstract: A liquid crystal composition including liquid crystalline compounds, polymerizable compounds, and dichroic dyes in which the polymerizable compound includes at least one compound represented by Formula (1), R11-MES-Sp11-P11??(1) in Formula (1), R11 is an alkyl group having 1 to 15 carbon atoms; MES is a mesogenic group having at least one ring, and in the ring in MES, at least one hydrogen atom is optionally substituted with -Sp11-P11; Sp11 is a single bond or an alkylene group having 1 to 10 carbon atoms, and in this alkylene group, at least one —CH2— is optionally substituted with —O—, —CO—, —COO—, —OCO—, or —OCOO—, and at least one —(CH2)2— is optionally substituted with —CH?CH— or —C?C—, and in these groups, at least one hydrogen atom is optionally substituted with a polymerizable group; P11 is a polymerizable group or a polar group, or a group having both polymerization and polarity.

Abstract: A subject is a polymerizable liquid crystal composition in which tilt alignment is easily developed and an optical anisotropic film obtained therefrom. A solution is a polymerizable liquid crystal composition containing one or more polymerizable liquid crystal compounds selected from compounds represented by formulas (1-1), (1-2) and (1-3), and a polymerizable liquid crystal compound represented by formula (2-1). In the following formula, for example, Z11 and Z12 are hydrogen; W1 is independently hydrogen, fluorine or a methoxy; W2 and W3 are independently hydrogen or methyl; X1 is independently a single bond or —CH2CH2—; and for example, W4 is methyl; and X2 is —O—; and m1, m2, n1 and n2 are 2 to 15. Moreover, Z21 is hydrogen or methyl; R1 is an alkyl ester-containing substituent; W5 is hydrogen; X3 is —COO—; X4 is —O—, for example; and m3 is 2 to 15 and q1 is 0 to 2.

Abstract: A subject is to provide a polymerizable liquid crystal composition from which an optically anisotropic substance having twist alignment that is excellent in chemical strength (chemical resistance) and has only a small amount of alignment defects can be obtained. A solution is a polymerizable liquid crystal composition containing an optically active compound having a binaphthol moiety, an achiral polymerizable liquid crystal compound and a photopolymerization initiator having oxime ester.

Abstract: To provide an optically anisotropic substance having a negative uniaxial phase difference film and a positive uniaxial phase difference film, and excellent heat resistance and sputtering resistance. The positive uniaxial phase difference film is formed in combination with a bifunctional polymerizable liquid crystal compound, the negative uniaxial phase difference film is formed in combination of the bifunctional polymerizable liquid crystal compound with an optically active compound having a polymerizable binaphthol moiety, and additional thermosetting treatment (postcure) is applied after the negative uniaxial phase difference film is photocured, and when glass transition temperature after the negative uniaxial phase difference film is cured is 85° C. or higher and 115° C. or lower, additional thermosetting treatment temperature is adjusted to 220° C. or higher and 250° C. or lower, and when the glass transition temperature is higher than 115° C.

Abstract: A polymerizable liquid crystal composition is provided that can exhibit a uniform homogeneous alignment by coating the composition on a supporting substrate having been subjected to an alignment treatment. The polymerizable liquid crystal composition contains a mixture of polymerizable compounds containing a compound selected from a group of compounds represented by the formula (1-1) as a component A and a compound selected from a group of compounds represented by the formula (2-1) as a component B as essential components, and optionally containing a compound selected from a group of compounds represented by the formulae (3-1) to (3-3) as a component C and/or a compound selected from a group of compounds represented by the formula (4-1) as a component D, and contains at least one nonionic surfactant as a component E. Examples of each of the components are shown in the disclosure.

Abstract: To provide an infrared reflecting film that is prepared by using a specific polymerizable liquid crystal compound and a specific optically active compound and is hard to cause an alignment defect, and also to provide a laminated film having the infrared reflecting film. A solution is the infrared reflecting film formed of a polymerizable liquid crystal composition containing a specific amount of optically active compound (2) having a binaphthol moiety and a specific amount of achiral polymerizable liquid crystal compound (1).

Abstract: To provide a polymerizable liquid crystal composition showing good coating properties even when a support substrate has a low solvent resistance, and having uniform alignment properties. A polymerizable liquid crystal composition is prepared by containing as components an acrylate polymerizable liquid crystal compound, a compound represented by formula (3), and a non-liquid crystalline compound having an acryloyl group or a methacryloyl group as a reactive moiety, and having a functional group including a hydroxyl group as a reactive dilution solvent in one molecule. When the polymerizable liquid crystal composition is applied onto the support substrate, dried and irradiated with light, the polymerizable liquid crystal composition showing good coating properties even when the support substrate has the low solvent resistance, and having the uniform alignment properties can be obtained.

Abstract: A compound represented by the formula (1) is provided. A polymerizable liquid crystal composition containing the compound can be controlled in birefringence and is excellent in stability of a liquid crystal phase. An anisotropic polymer excellent in uniformity of alignment is obtained by coating and polymerizing the composition on a supporting substrate. In the formula (1), at least one of Ra represents a polymerizable group, A represents a ring group, Y and Z each represent a single bond or alkylene; in which —CH2— in the alkylene may be replaced by another group, and m and n each represent an integer of from 0 to 5.

Abstract: To provide an optically anisotropic substance having a negative uniaxial phase difference film and a positive uniaxial phase difference film, and excellent heat resistance and sputtering resistance. The positive uniaxial phase difference film is formed in combination with a bifunctional polymerizable liquid crystal compound, the negative uniaxial phase difference film is formed in combination of the bifunctional polymerizable liquid crystal compound with an optically active compound having a polymerizable binaphthol moiety, and additional thermosetting treatment (postcure) is applied after the negative uniaxial phase difference film is photocured, and when glass transition temperature after the negative uniaxial phase difference film is cured is 85° C. or higher and 115° C. or lower, additional thermosetting treatment temperature is adjusted to 220° C. or higher and 250° C. or lower, and when the glass transition temperature is higher than 115° C.

Abstract: A subject is to provide a polymerizable liquid crystal composition from which an optically anisotropic substance having twist alignment that is excellent in chemical strength (chemical resistance) and has only a small amount of alignment defects can be obtained. A solution is a polymerizable liquid crystal composition containing an optically active compound having a binaphthol moiety, an achiral polymerizable liquid crystal compound and a photopolymerization initiator having oxime ester.

Abstract: A subject is a polymerizable liquid crystal composition in which tilt alignment is easily developed and an optical anisotropic film obtained therefrom. A solution is a polymerizable liquid crystal composition containing one or more polymerizable liquid crystal compounds selected from compounds represented by formulas (1-1), (1-2) and (1-3), and a polymerizable liquid crystal compound represented by formula (2-1). In the following formula, for example, Z11 and Z12 are hydrogen; W1 is independently hydrogen, fluorine or a methoxy; W2 and W3 are independently hydrogen or methyl; X1 is independently a single bond or —CH2CH2—; and for example, W4 is methyl; and X2 is —O—; and m1, m2, n1 and n2 are 2 to 15. Moreover, Z21 is hydrogen or methyl; R1 is an alkyl ester-containing substituent; W5 is hydrogen; X3 is —COO—; X4 is —O—, for example; and m3 is 2 to 15 and q1 is 0 to 2.

Abstract: To provide a three-dimensional image display apparatus having patterned retarder 303 that is excellent in adhesion between transparent support substrate 301 and alignment film 302. A mixture containing a polymerizable liquid crystal compound and a peeling preventive agent is prepared. Here, the peeling preventive agent has as a polar group any one of a hydroxyl group, a carboxyl group, a phosphate group, a sulfonate group, an amino group, a mercapto group and an isocyanate group, and also has a polymerizable group. Then, an alignment layer is arranged on a transparent support substrate, and subjected to patterned treatment, and the mixture is coated, and a coated surface is dried and cured to form a patterned retarder, and thus a three-dimensional image display apparatus having excellent reliability, such as adhesion, is obtained.

Abstract: To provide a polymerizable liquid crystal composition showing good coating properties even when a support substrate has a low solvent resistance, and having uniform alignment properties. A polymerizable liquid crystal composition is prepared by containing as components an acrylate polymerizable liquid crystal compound, a compound represented by formula (3), and a non-liquid crystalline compound having an acryloyl group or a methacryloyl group as a reactive moiety, and having a functional group including a hydroxyl group as a reactive dilution solvent in one molecule. When the polymerizable liquid crystal composition is applied onto the support substrate, dried and irradiated with light, the polymerizable liquid crystal composition showing good coating properties even when the support substrate has the low solvent resistance, and having the uniform alignment properties can be obtained.

Abstract: The invention provides a compound represented by formula (1). In the formula (1), R1 is hydrogen, methyl or ethyl; X1 is a single bond, —O— or —OCO—; X2 is a single bond, —O—, —COO— or —OCO—; A1 and A2 are each independently a divalent aromatic ring or a divalent cyclohexane ring, and in these rings, arbitrary hydrogen may be replaced by halogen, alkyl having 1 to 3 carbons or halogenated alkyl having 1 to 3 carbons; Z1 is independently a single bond, —O—, —S—, —COO—, —OCO—, —CH2O—, —OCH2—, —CH?CH—COO—, —OCO—CH?CH—, —CH2CH2—COO—, —OCO—CH2CH2—, —CON(R)— or —N(R)CO—; R is hydrogen or methyl; Y is a terpenoid residue or a steroid residue; m is an integer from 0 to 20; and n is an integer from 0 to 3.

Abstract: The main aim of the invention is to provide a polymerizable compound that is excellent in the stability of a liquid crystal phase, a polymerizable liquid crystal composition, and an anisotropic polymer in which the optical anisotropy can be adjusted and a uniform orientation is excellent. An anisotropic polymer having a uniform orientation formed by polymerization of a paint film that was prepared by application of a polymerizable liquid crystal composition including a compound represented by formula (1) having a benzyl ester moiety in the minor axis direction of the molecule to a supporting substrate; wherein at least one of Ra is a polymerizable group, A is a divalent cyclic-structure group, B is phenyl that may have a substituent, Y and Z are a single bond or alkylene, and m and n are an integer from 0 to 5.