Abstract: An object of the present invention is to provide a drug delivery system capable of sustainedly releasing a drug noninvasively at any given point in time. The present invention relates to a liposome complex comprising a liposome membrane-constituting substance bonded to a light-absorbing compound having an absorption wavelength in the near-infrared region, selected from the group consisting of indocyanine green dyes, phthalocyanine dyes, squarylium dyes, croconium dyes, and diimmonium dyes.

Abstract: Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.

Abstract: A manufacturing apparatus and a manufacturing method of pet food are provided. The manufacturing apparatus comprises a material inlet through which a kneaded material is fed, the kneaded material being obtained through kneading a raw pet food material; an extrusion molding section configured to extrude the kneaded material through an extruding outlet; a cutter configured to cut the kneaded material extruded through the extruding outlet at desired intervals to form material grains; a reservoir disposed in a location to receive the material grains falling due to the cutting; an agitating section provided in the reservoir and configured to agitate the material grains; a heating section configured to heat the material grains while the material grains are agitated by the agitating section; and a drying section configured to dry the material grains within the reservoir after the heating.

Abstract: An object of the present invention is to provide a drug delivery system capable of sustainedly releasing a drug noninvasively at any given point in time. The present invention relates to a liposome complex comprising a liposome membrane-constituting substance bonded to a light-absorbing compound having an absorption wavelength in the near-infrared region, selected from the group consisting of indocyanine green dyes, phthalocyanine dyes, squarylium dyes, croconium dyes, and diimmonium dyes.

Abstract: Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.

Abstract: A manufacturing apparatus and a manufacturing method of pet food are provided. The manufacturing apparatus comprises a material inlet through which a kneaded material is fed, the kneaded material being obtained through kneading a raw pet food material; an extrusion molding section configured to extrude the kneaded material through an extruding outlet; a cutter configured to cut the kneaded material extruded through the extruding outlet at desired intervals to form material grains; a reservoir disposed in a location to receive the material grains falling due to the cutting; an agitating section provided in the reservoir and configured to agitate the material grains; a heating section configured to heat the material grains while the material grains are agitated by the agitating section; and a drying section configured to dry the material grains within the reservoir after the heating.

Abstract: Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.

Abstract: Disclosed is a medium-molecular weight fucoidan which can be used in treating and/or preventing proliferative diseases, in particular, cancer. Specifically disclosed are a medium-molecular weight fucoidan, a method for producing the same, a medicinal composition containing the same, and use of the medium-molecular weight fucoidan in producing a drug for treating and/or preventing preventing proliferative diseases, in particular, cancer. The aforesaid medium-molecular weight fucoidan has an average molecular weight of about 6,000 to about 2,000,000, preferably an average molecular weight of about 40,000 to about 330,000, more preferably an average molecular weight of about 40,000 to about 244,000, and still more preferably an average molecular weight of about 80,000 to about 200,000.

Abstract: A photodynamic hyperthermic chemotherapy of cancer comprising topically injecting a photosensitive dye agent, specifically indocyanine green, in the form of an acidic liquid formulation to a tumor or cancer tissue, or a surgically removed site thereof of a patient, and irradiating the tissue or site with light having such an output wavelength that the photosensitive dye agent absorbs the light and generates heat; and an apparatus and a system for photodynamic hyperthermic chemotherapy of cancer comprising a light source and a probe having a light introducing portion capable of topically irradiating a tumor or cancer tissue or a surgically removed site thereof of a patient with light derived from the light source by a continuous wave or a pulse wave at an output wavelength of 600 to 1600 nm and an output of 5000 mW or more.

Abstract: The present invention has an object of revealing an epidermis regeneration effect of various chitin derivatives and providing an agent for therapy or treatment for wound which can be clinically used effectively. According to the present invention, it has been evidenced that N-acetyl-D-glucosamine has an effect of promoting proliferation of an epidermis keratinized cell. Accordingly, the present invention provides a proliferation promoting agent for epidermis keratinized cell comprising N-acetyl-D-glucosamine. According to another aspect of the present invention, there is provided a regeneration promoting agent or protecting agent for epithelium, skin or dermis comprising the proliferation promoting agent. Further, a therapeutic agent for wound is provided.

Abstract: The present invention has an object of revealing an epidermis regeneration effect of various chitin derivatives and providing an agent for therapy or treatment for wound which can be clinically used effectively. According to the present invention, it has been evidenced that N-acetyl-D-glucosamine has an effect of promoting proliferation of an epidermis keratinized cell. Accordingly, the present invention provides a proliferation promoting agent for epidermis keratinized cell comprising N-acetyl-D-glucosamine. According to another aspect of the present invention, there is provided a regeneration promoting agent or protecting agent for epithelium, skin or dermis comprising the proliferation promoting agent. Further, a therapeutic agent for wound is provided.

Abstract: Provided is an N-alkyl chitosan derivative having an ultraviolet ray-curable functional group represented by formula (I) given below: where l+m+n=1, 0<l<1, 0<m<0.5, 0<n<1 and R1 is represented by formula (II) given below: where R2 denotes a hydrogen atom or a methyl group.

Abstract: Apparatus is disclosed for grading and measuring surfaces such as roadbeds which have curved and inclined profiles which may have different shapes in successive transverse sections of the roadbed. A blade and screw cutter are supported by a frame which extends over the surface being worked, and these tools are movable along this frame. The tools are movable toward and away from the surface being shaped in response to a control means which has memorized the appropriate positions, or by reference to a deformable rule which may also be reshaped in response to computer-memorized data. According to a disclosed method, the rule is reshaped for different sections of the surface.An apparatus for checking and measuring a surface which has a curved profile includes a plurality of piston-cylinder units which are mounted on a main frame.

Abstract: An inclined roadbed is paved by vehicles which are connected by wires to uphill anchor vehicles. A paving vehicle on the inclined surface has a device for projecting a laser beam to a beam-receiving device on its respective anchor vehicle. The height of the wire connection point on the anchor vehicle is changed in response to signals from the beam-receiving device, so as to equalize the forces exerted on the inclined surface by the left and right sides of the paving vehicle. For paving surfaces such as automobile test tracks which have compound curvatures, a pavement laying apparatus has a curved surface formed by a plurality of interconnected screed plates which are each connected to a respective screw jack. A microcomputer stores data representing the desired shape of the pavement at different points along the travel path of the apparatus.

Abstract: An inclined roadbed is paved by vehicles which are connected by wires to uphill anchor vehicles. A paving vehicle on the inclined surface has a device for projecting a laser beam to a beam-receiving device on its respective anchor vehicle. The height of the wire connection point on the anchor vehicle is changed in response to signals from the beam-receiving device, so as to equalize the forces exerted on the inclined surface by the left and right sides of the paving vehicle. For paving surfaces such as automobile test tracks which have compound curvatures, a pavement laying apparatus has a curved surface formed by a plurality of interconnected screed plates which are each connected to a respective screw jack. A microcomputer stores data representing the desired shape of the pavement at different points along the travel path of the apparatus.

Abstract: Apparatus is disclosed for grading and measuring surfaces such as roadbeds which have curved and inclined profiles which may have different shapes in successive transverse sections of the roadbed. A blade and screw cutter are supported by a frame which extends over the surface being worked, and these tools are movable along this frame. The tools are movable toward and away from the surface being shaped in response to a control means which has memorized the appropriate positions, or by reference to a deformable rule which may also be reshaped in response to computer-memorized data. According to a disclsoed method, the rule is reshaped for different sections of the surface.An apparatus for checking and measuring a surface which has a curved profile includes a plurality of piston-cylinder units which are mounted on a main frame.

Abstract: A compactor having the roller shafts mounted for changing the inclination of the roller through a linkage system. The compactor is connected to an anchor vehicle by a tension member which deters lateral shifting and has a sensor indicating the inclination angle. The sensor is connected to a control which varies the tension.

Abstract: A space diversity reception system which minimizes the inband amplitude and/or phase dispersion by controlling the phase shifter is described. According to the present invention, the interference waves in the two antenna outputs are combined in anti-phase condition. The phase shifter control direction is decided by the sign of the two parameters. One of them is difference between two antenna levels at the center frequency of the pass-band, and the other is the difference of the combined signal levels at the extreme edges of the pass-band. The control means comprises four detectors for detecting said levels, two subtractors for providing said level differences between them, and the control circuit for deciding the phase shifter control direction.

Abstract: A process for producing a liquid seasoning, which comprises allowing a hydrolyzate of soy sauce raw materials, in liquid state at a pH of 4.0 to 9.0, to contact with immobilized cells of soy sauce lactic acid bacteria for 30 minutes or more to obtain a lactic fermentation mixture, and subjecting the mixture to the fermentation by a soy sauce yeast.

Abstract: A space diversity reception system which minimizes the inband amplitude and/or phase dispersion by controlling the phase shifter is described. According to the present invention, the interference waves in the two antenna outputs are combined in anti-phase condition. The phase shifter control direction is decided by the sign of the two parameters. One of them is difference between two antenna levels at the center frequency of the pass-band, and the other is the difference of the combined signal levels at the extreme edges of the pass-band. The control means comprises four detectors for detecting said levels, two subtractors for providing said level difference between them, and the control circuit for deciding the phase shifter control direction.