Patents by Inventor Yoshiharu Takazawa

Yoshiharu Takazawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biphenylamidine derivatives
    Patent number: 6706745
    Abstract: The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically applicable FXa inhibitor.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: March 16, 2004
    Assignee: Teijin Limited
    Inventors: Takayuki Hara, Tomohisa Nakada, Yasunobu Takano, Satoshi Sugiura, Takaharu Tsutsumi, Yoshiharu Takazawa, Reiko Takarada
  • Biphenylamidine derivatives
    Patent number: 6348478
    Abstract: The present invention is a biphenylamidine derivative represented by the formula (1) or a pharmaceutically acceptable derivative thereof: and the biphenylamidine derivative or the pharmaceutically acceptable derivative thereof is a novel compound which can be used as a clinically applicable FXa inhibitor.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: February 19, 2002
    Assignee: Teijin Limited
    Inventors: Takayuki Hara, Tomohisa Nakada, Yasunobu Takano, Satoshi Sugiura, Takaharu Tsutsumi, Yoshiharu Takazawa, Reiko Takarada
  • Medium for culturing animal cells
    Patent number: 5824552
    Abstract: A method is disclosed for culturing animal cells in a medium characterized n that said medium contains a compound represented by the general formula ##STR1## wherein, R denotes COOM or CHO, herein M denotes hydrogen, an alkali metal or a C.sub.1 to C.sub.3 alkyl group, and n is an integer of 1 to 3.According to the present method, proliferation of animal cells can be enhanced with good reproducibility.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: October 20, 1998
    Assignees: Teijin Limited, Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Yoshiharu Takazawa, Takami Arai, Masamichi Motoki, Kenji Nagura, Seiichi Yokoyama, Yoshinobu Miyatsu, Hiroshi Mizokami
  • Fed batch culture method for protein secreting cells
    Patent number: 5443968
    Abstract: In a process of production of a useful protein by culturing a human embryonal kidney cell-derived 293 strain which is introduced with a useful protein-expressing gene, it becomes possible to obtain a culture fluid containing the useful protein in a high concentration using an extremely small amount of the medium, by carrying out a fed-batch culture and adding a sugar or a sugar and a calcium in a specified stage of the culture.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: August 22, 1995
    Assignee: Teijin Limited
    Inventors: Yoshiharu Takazawa, Seiichi Yokoyama
  • Process for continuously culturing adherent animal cells
    Patent number: 5219752
    Abstract: Adherent 293 human kidney cells are continuously cultured in suspension in serum-free medium. Fresh medium is fed into a culture vessel and spent medium is withdrawn from the vessel. The 293 cells are maintained in small aggregates in suspension at a density of at least 3.times.10.sup.6 cells/ml for 30 days. The formation of large cell clumps is prevented by maintaining the concentration of calcium in the serum-free medium at 0.002 mM to 0.3 mM.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: June 15, 1993
    Assignee: Teijin, Limited
    Inventors: Yoshiharu Takazawa, Michiyuki Tokashiki