Patents by Inventor Yoshiharu Yokoo
Yoshiharu Yokoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7521079Abstract: The present invention relates to a method for producing a liquid plant extract containing plant powder, which includes concentrating a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the active ingredient; a process for producing a plant extract containing plant powder, which is characterized by concentrating and drying a liquid extract containing an active ingredient in the presence of the plant powder.Type: GrantFiled: June 21, 2002Date of Patent: April 21, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yasushi Sakai, Yoshiharu Yokoo
-
Patent number: 7033580Abstract: Disclosed is a safe and effective hair-growing agent comprising a protein kinase C-specific inhibitor.Type: GrantFiled: December 4, 2002Date of Patent: April 25, 2006Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tomoya Takahashi, Yoshiharu Yokoo, Toshikazu Kamiya, Akio Shirai, Tatsuya Tamaoki
-
Publication number: 20040161524Abstract: The present invention relates to a method for producing a liquid plant extract containing plant powder, which comprises concentrating a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the active ingredient; a process for producing a plant extract containing plant powder, which is characterized by comprises concentrating and drying a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the active ingredient; a liquid plant extract or plant extract containing plant powder which comprises a liquid extract or plant extract containing the active ingredient obtained from a plant containing the active ingredient and comprises plant powder, and in which the content of the active ingredient in the liquid extract or plant extract is higher than that in the plant; and a food and drink or feed to which the liquid plant extract or plant extraType: ApplicationFiled: December 19, 2003Publication date: August 19, 2004Inventors: Yasushi Sakai, Yoshiharu Yokoo
-
Publication number: 20030086885Abstract: Disclosed is a safe and effective hair-growing agent comprising a protein kinase C-specific inhibitor.Type: ApplicationFiled: December 4, 2002Publication date: May 8, 2003Inventors: Tomoya Takahashi, Yoshiharu Yokoo, Toshikazu Kamiya, Akio Shirai, Tatsuya Tamaoki
-
Patent number: 6506370Abstract: Disclosed is a safe and effective hair-growing agent comprising a protein kinase C-specific inhibitor.Type: GrantFiled: March 24, 1997Date of Patent: January 14, 2003Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tomoya Takahashi, Yoshiharu Yokoo, Toshikazu Kamiya, Akio Shirai, Tatsuya Tamaoki
-
Patent number: 6214831Abstract: The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or animals which comprise, as an active ingredient, a compound represented by formula (I): wherein represents (wherein R1 represents hydrogen or hydroxy, and R2 represents hydrogen or lower alkyl; or R1 and R2 are combined together to form a bond) or (wherein R3 represents lower alkyl); n represents 0 when is and represents 1 when is and X− represents an anion, or a salt thereof.Type: GrantFiled: September 15, 1999Date of Patent: April 10, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoshiharu Yokoo, Yoshinori Kobayashi, Yumiko Nakano
-
Patent number: 6126940Abstract: A hair-growing agent comprising proanthocyanidin as the active ingredient. The present invention provides a hair-growing agent having strong pharmaceutical effects.Type: GrantFiled: December 30, 1996Date of Patent: October 3, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tomoya Takahashi, Yoshinori Kobayashi, Michio Kawamura, Yoshiharu Yokoo, Toshikazu Kamiya, Tatsuya Tamaoki
-
Patent number: 6027720Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: July 13, 1994Date of Patent: February 22, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
-
Patent number: 5998421Abstract: The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or animals which comprise, as an active ingredient, a compound represented by formula (I): ##STR1## wherein >A--B-- represents >CR.sup.1 --NR.sup.2 -- (wherein R.sup.1 represents hydrogen or hydroxy, and R.sup.2 represents hydrogen or lower alkyl; or R.sup.1 and R.sup.2 are combined together to form a bond) or >C.dbd.N.sup.+ (R.sup.3)-- (wherein R.sup.3 represents lower alkyl); n represents 0 when >A--B-- is >CR.sup.1 --NR.sup.2 --, and represents 1 when >A--B-- is >C.dbd.N.sup.+ (R.sup.3)--; and X.sup.- represents an anion, or a salt thereof.Type: GrantFiled: February 5, 1998Date of Patent: December 7, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoshiharu Yokoo, Yoshinori Kobayashi, Yumiko Nakano
-
Patent number: 5994518Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: July 9, 1997Date of Patent: November 30, 1999Assignee: Kyowa Hakko Co., LtdInventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
-
Patent number: 5876993Abstract: The present invention relates to a process for producing a cholesterol-reduced substance obtained by converting cholesterol in a substance to epicholesterol, as well as to a novel cholesterol oxidase and a novel epicholesterol dehydrogenase which are used in the process, a process for production of these enzymes and a method for the production of epicholesterol with the use of the above mentioned epicholesterol dehydrogenase.Type: GrantFiled: August 23, 1995Date of Patent: March 2, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Chiaki Saito, Hideyo Senda, Yoshiharu Yokoo
-
Patent number: 5795968Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: January 10, 1997Date of Patent: August 18, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
-
Patent number: 5714581Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: May 3, 1995Date of Patent: February 3, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
-
Patent number: 5681720Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: May 3, 1995Date of Patent: October 28, 1997Assignee: Kyowa Hakko Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
-
Patent number: 5503988Abstract: The present invention relates to a process for producing a cholesterol-reduced substance obtained by converting cholesterol in a substance to epicholesterol, as well as to a novel cholesterol oxidase and a novel epicholesterol dehydrogenase which are used in the process, a process for production of these enzymes and a method for the production of epicholesterol with the use of the above mentioned epicholesterol dehydrogenase.Type: GrantFiled: February 10, 1994Date of Patent: April 2, 1996Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Chiaki Saito, Hideyo Senda, Yoshiharu Yokoo
-
Patent number: 5468474Abstract: The present invention relates to N-acylglutamine derivatives of formula (I): ##STR1## The N-acylglutamine derivatives are well compatible with oily bases and have good skin-moisturizing activity and hair growth-stimulative effect. These are useful as cosmetics and hair growth stimulants.Type: GrantFiled: July 27, 1994Date of Patent: November 21, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shinkichi Honda, Kenji Torii, Yoichiro Arai, Masaji Kasai, Hiromasa Kato, Takao Iida, Tomoya Takahashi, Yoshiharu Yokoo, Toshikazu Kamiya, Tatsuya Tamaoki
-
Patent number: 5432160Abstract: A nutrient composition such as infusions and nutrient preparations, which contains .beta.-alanyl-L-glutamine.Type: GrantFiled: August 29, 1994Date of Patent: July 11, 1995Assignee: Kyowa Hakko Kohyo Co., Ltd.Inventors: Takahiro Hara, Yoshiharu Yokoo
-
Patent number: 5376545Abstract: The present invention provides a DNA coding for uricase from the genus Cellulomonas and a process for producing uricase using a microorganism which carries a recombinant DNA containing the DNA.Type: GrantFiled: December 3, 1992Date of Patent: December 27, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Makoto Yagasaki, Shuichi Ishino, Kazuhisa Iwata, Masaki Azuma, Sadao Teshiba, Masaru Hasegawa, Kazuo Yamaguchi, Keiichi Yano, Yoshiharu Yokoo, Yukio Hashimoto
-
Patent number: 5362853Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: December 22, 1992Date of Patent: November 8, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Yoshinori Komatsu
-
Patent number: 5316767Abstract: Disclosed is a whitening cosmetic composition comprising .gamma.-L-glutamyl-L-cystine, .gamma.-L-glutamyl-L-cysteine disulfide, oxidized glutathione or a derivative thereof, the amino group of which is acylated with an alkanoyl group or an aroyl group. The whitening cosmetic composition of the present invention have extremely good in water solubility and heat stability and stability during storage and show a melanin formation inhibitory activity against melanoma cells without any cytotoxicity.Type: GrantFiled: December 3, 1992Date of Patent: May 31, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takahiro Hara, Seigo Takasawa, Yoshiharu Yokoo, Tadayasu Furukawa