Patents by Inventor Yoshihide Fujiyama

Yoshihide Fujiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
    Patent number: 7582427
    Abstract: An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform of UGT1, by assaying a mutation in the common regions, particularly a mutation in exon 5 region, and further adding the detection of (a) mutation(s) in a plurality of exon regions, mutations of UGT1 gene can effectively assayed. A nucleic acid chip using nucleic acid probes is used as a way of detecting (a) mutation(s).
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: September 1, 2009
    Assignee: National University Corporation Shiga University of Medical Science
    Inventors: Hiroshi Sato, Yoshihide Fujiyama, Kazuo Yamamoto
  • Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
    Publication number: 20060257960
    Abstract: An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform of UGT1, by assaying a mutation in the common regions, particularly a mutation in exon 5 region, and further adding the detection of (a) mutation(s) in a plurality of exon regions, mutations of UGT1 gene can effectively assayed. A nucleic acid chip using nucleic acid probes is used as a way of detecting (a) mutation(s).
    Type: Application
    Filed: February 13, 2003
    Publication date: November 16, 2006
    Inventors: Hiroshi Sato, Yoshihide Fujiyama, Kazuo Yamamoto
  • Preventive and/or therapeutic drugs for inflammatory intestinal diseases
    Publication number: 20060135588
    Abstract: The object of the present invention is to provide a medicament useful for preventing and/or treating inflammatory bowel disease.
    Type: Application
    Filed: September 9, 2003
    Publication date: June 22, 2006
    Inventors: Yoshio Araki, Akira Andoh, Yoshihide Fujiyama
  • Novel prophylactics/remedies for immunopathy
    Publication number: 20060024322
    Abstract: A prophylactic/remedy for immunopathy for immunopathy comprising, as an active ingredient, modifications of Staphylococcal enterotoxin B (SEB) with substitution of at least one amino acid residues within the amino acid sequence of natural type SEB, or derivatives thereof, wherein the SEB modifications or derivatives thereof have inhibitory activity on T cell activation wherein they interact with specific V? component of T cell receptor (TCR) but are reduced in their immunological responsiveness to SEB without inducing elimination of T cells having specific V? component, the elimination being normally induced by natural type SEB or recombinant wild-type SEB.
    Type: Application
    Filed: May 5, 2005
    Publication date: February 2, 2006
    Inventors: Takumi Sasaki, Kazuhiko Kimachi, Kenji Soejima, Yumi Kimura, Chikateru Nozaki, Yoshihide Fujiyama