Abstract: A sewing machine with a dust removing device prevents trouble such as faulty sewing caused when dust including waste thread and waste cloth is collected under a throat plate, in performing, for example, interlock stitch sewing by an overlock sewing machine. Specifically, an upward air introducing path is provided, through which the cooling airflow generated by a cooling fan actuated during sewing operation is fed to an air introducing path for oil cooling underneath a lubricating oil storage part, and, through which the cooling airflow passing through the air introducing path for oil cooling is blown up from the underside of a frame to a needle location of the throat plate, in order to blow up the dust. An opening of one end of a suction pipe for collecting dust attached to the frame is disposed sidewise above the throat plate.