Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.

Abstract: A cathode-depositing electrodeposition coating composition having excellent low-temperature curability comprising as essential ingredients(A) 100 parts by weight of a reaction product of (1) a high molecular compound having a molecular weight of 500 to 5,000 and containing carbon-carbon double bonds with an iodine number of 50 to 500 and 3 to 12% by weight of oxirane oxygen, and (2) 30 to 300 millimoles, per 100 g of the high molecular compound (1), of a specified amine compound,(B) 10 to 200 parts by weight of a reaction product of a specified diglycidyl compound with 1.9 to 2.1 moles, per molecule of the diglycidyl compound, of an alpha, beta-unsaturated carboxylic acid or an unsaturated fatty acid having a molecular weight of 100 to 350 and containing at least 10% by weight of a carbon-carbon double bond, or a mixture of both,(C) 0.

Abstract: A cathode-depositing electrodeposition coating composition comprising an aqueous solution or dispersion containing(A) a reaction product of (1) epoxidized diene polymer, (2) an amine and optionally, (3) polymerizable unsaturated aliphatic acid;(B) a reaction product of bisphenol epoxy resin and a polymerizable aliphatic acid;(C) a blocked polyisocyanate compound; and(D) manganese dioxide or an organic salt of manganese, cobalt or copper.The composition gives a coating film having excellent properties when electrodepositing and baking at a relatively low baking temperature.

Abstract: A cathode-precipitating electrodeposition coating composition consisting essentially of (A) 100 parts of a high-molecular-weight compound having a molecular weight of 500 to 10,000 and containing an amino group and a carbon-carbon double bond, (B) 3 to 200 parts by weight of a reaction product obtained by reacting an unsaturated carboxylic acid having 3 or 4 carbon atoms with the terminal glycidyl group of a glycidyl compound obtained by reacting a bisphenol with epichlorohydrin, and (C) 0.2 to 20 parts by weight of an oil-soluble manganese salt of a monoester of a 1,2-dicarboxylic acid or a manganese salt of sulfonated or maleinized polybutadiene having a molecular weight of 300 to 3,000.

Abstract: A cathode-precipitating electrodeposition coating having excellent low-temperature curability, said composition consisting essentially of(A) 100 parts by weight of a high molecular compound having a molecular weight of 500 to 10,000 and containing carbon-carbon double bonds with an iodine value of 50 to 500 and 30 to 300 millimoles of amino groups per 100 g,(B) 10 to 200 parts by weight of a product of reaction of a diglycidyl compound represented by the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.

Abstract: A wax emulsion is disclosed which upon application to a material forms a film capable of keeping the material water-proof or otherwise protective against ambient influences. The quality of the wax emulsion is improved by the combination of a hydrocarbon wax with a liquid polybutadiene a polybutene or a polyisobutylene.

Abstract: An aqueous composition for the protection of paint surfaces comprises an aqueous emulsion containing as essential components (a) an oxygen-containing wax, (b) an emulsifying agent, (c) a fine powder of an inorganic material having a silicon content of not less than 23%, and (d) a fine powder of an inorganic or organic material substantially free of silicon.

Abstract: A self-curable coating composition for cathode-precipitating electrodeposition is disclosed which essentially comprises a water-dispersible resin having a carbon-carbon double bond and a tertiary amino group and an epoxy resin having a teritary amino group and an unsaturated group of the formula ##STR1## The two resins are neutralized by an acid to render the composition water-soluble or water-dispersible.

Abstract: In a method for purifying a crude epoxidation product of a liquid conjugated diolefin polymer or a vegetable oil which comprises the steps of adding an aqueous washing agent to a crude epoxidation product which is obtained by the reaction of a liquid conjugated diolefin polymer or a vegetable oil with an organic peracid or an epoxidizing agent capable of generating an organic peracid in situ, stirring the mixture, leaving the mixture to stand to induce phase separation and thereafter withdrawing the organic layer, the improvement wherein 50 to 300 parts by weight, per 100 parts by weight of the crude epoxidation product, of a 10-80% by weight aqueous solution of isopropanol is used as the washing agent.

Abstract: A process for preparing a cathodic electrodepositable coating composition which comprises, in sequence,(i) epoxidizing a high-molecular-weight compound containing a carbon-carbon double bond and having a molecular weight of 500 to 10,000 and an iodine value of 100 to 500 to form an epoxidized high-molecular-weight compound containing 0.5 to 12% by weight of oxirane oxygen,(ii) reacting a part of the epoxy groups of the epoxidized high-molecular-weight compound with a basic amine compound of the general formula ##STR1## wherein R.sub.1 and R.sub.2, independently from each other, represent a hydrocarbon group having 1 to 10 carbon atoms which may be partly replaced by a hydroxyl group, and R.sub.1 and R.sub.2 together may form a cyclic structure,(iii) reacting a part or the whole of the remaining epoxy groups with an .alpha.,.beta.-unsaturated monocarboxylic acid of the general formula ##STR2## wherein R.sub.3 and R.sub.

Abstract: A curable resin composition consisting essentially of an amidated polybutadiene and a phenolic resin, and a laminate containing the resin composition in cured form and having excellent electrical properties and cold punching workability.

Abstract: A curable resin composition is disclosed for use in the manufacture of laminates applied to electronics equipment. The composition essentially comprises a resol type phenolic resin which is obtained from the reaction of an amidated drying oil and a phenol-formal dehyde in the presence of an alkali catalyst. Another form of the composition includes an amidated butadiene polymer to provide improved flexibility and chemicals resistance.

Abstract: In a method for producing a low molecular weight polymer or copolymer by introducing metallic sodium or an organic sodium compound as a polymerization initiator, an alkyl aryl compound as a chain transfer agent, an inert hydrocarbon as a solvent and a conjugated diolefin or both a conjugated diolefin and a vinyl compound having anionic copolymerization activity with diolefins as a monomer or monomers, into a polymerization vessel and polymerizing or copolymerizing therein successively at a temperature of 0.degree. to 100.degree. C., the improvement in the method for producing a low molecular weight polymer or copolymer having a number average molecular weight of 300 to 10,000 with good reproducibility is characterized in that 0.05 to 10 mole % per 1 mole of the said polymerization initiator, of oxygen is fed into said polymerization vessel.

Abstract: A coating composition for cathode-precipitating electrodeposition consisting essentially of(A) 100 parts by weight of an unsaturated organic compound having a molecular weight of 500 to 10,000 containing a carbon-carbon double bond in an amount corresponding to an iodine value of 100 to 500, said unsaturated organic compound having bonded thereto, through a carbon-carbon bond, basic groups of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as defined in claim 1, the amount of said basic groups in said component (A) being 0.02 to 0.3 mole per 100 g of said component (A), and(B) 3 to 100 parts by weight of at least one compound represented by the general formula ##STR2## wherein R.sub.5, R.sub.6, n, m, Y and Y' are as defined in claim 1, said component (A) and said component (B) being neutralized with an organic acid or an inorganic acid and dissolved or dispersed in water.

Abstract: A coating composition for cathode-precipitating electrodeposition consisting essentially of (A) 100 parts by weight of an unsaturated organic compound having a molecular weight of 300 to 5,000 containing a carbon-carbon double bond in an amount corresponding to an iodine value of 100 to 500, said unsaturated organic compound having bonded thereto, through a carbon-carbon bond, basic groups of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as defined in claim 1,the amount of said basic groups in said component (A) being 0.05 to 0.5 mole per 100 g of said component (A), and (B) 3 to 100 parts by weight of at least one compound represented by the general formula ##STR2## wherein R.sub.5, R.sub.6, n, m, Y and Y' are as defined in claim 1, said component (A) and said component (B) being neutralized with an organic acid or an inorganic acid and dissolved or dispersed in water.

Abstract: An aqueous pigment dispersion is obtained by using a reactive dispersing agent for the dispersion of a pigment, and the aforesaid reactive dispersing agent is prepared by neutralizing a homopolymer and/or a copolymer of butadiene having a required amount of an acidic group selected from the group consisting of unsaturated dicarboxylic acids, the anhydrides thereof, and sulfonic acid group, by a water soluble base.

Abstract: An improved electrocoating composition is described for cathodic electrodepositions, which composition comprises a water-miscible mixture of a substituted conjugated diene polymer or copolymer of a specific general formula, with not more than 30 parts by weight for 100 part of said diene of an epoxy resin, a petroleum resin or mixtures thereof, the mixture being neutralized with an acid.

Abstract: A process of transmetalating organoalkali metals is disclosed, wherein organoalkali metal compounds are reacted with hydrocarbon compounds in the presence of predetermined amounts of oxygen.

Abstract: An electrophoretic coating composition comprising as an essential component a film-forming ingredient containing (1) an adduct of an .alpha.,.beta.-unsaturated dicarboxylic acid or anhydride thereof to a mixture of a liquid conjugated diene polymer and a polyunsaturated rubber or an 1,2-polybutadiene resin, (2) a mixture of said adduct (1) and an adduct of an .alpha.,.beta.-unsaturated dicarboxylic acid or anhydride thereof to a natural drying oil or thermally polymerized product thereof or (3) an adduct of the same acid or anhydride to a mixture of the liquid conjugated diene polymer, 1,2-polybutadiene or polyunsaturated rubber and natural drying oil or thermally polymerized product thereof. In one embodiment, the adducts (1), (2) and (3) may be substituted with modified ones prepared by reaction of the former with an alcohol, respectively.

Abstract: A paint comprising as a film-forming component a resinous substance obtained by reacting epoxidized polybutadiene containing an unsaturated group and having a low degree of polymerization with a primary or secondary amine. The resinous substance can be easily rendered water-soluble, and is useful as water-base paints, particularly electrodeposition paints that deposit on a cathode. Instead of the epoxidized polybutadiene, epoxidized drying oils or semi-drying oils or epoxidized petroleum resins can also be used.