Patents by Inventor Yoshihiko Kitaura
Yoshihiko Kitaura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240255477Abstract: A method for estimating a state of wax in a rubber compound according to a first aspect includes the following: acquiring a chromatogram of an extracted component, by separating components thereof, in which the wax is extracted from the rubber compound including the wax; and deriving a distribution of normal hydrocarbons in the wax based on the chromatogram.Type: ApplicationFiled: January 16, 2024Publication date: August 1, 2024Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yuko IWASAKI, Yoshihiko KOMORI, Yumi KITAURA, Hiroaki YAMADA
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Patent number: 9771316Abstract: The invention provides a compound having a selective inhibitory activity against highly-expressed LAT-1 in tumor cell. The compound is represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, and a LAT-1 inhibitor comprising the same.Type: GrantFiled: January 21, 2014Date of Patent: September 26, 2017Assignees: Osaka University, KNC Laboratories Co., Ltd.Inventors: Yoshikatsu Kanai, Shushi Nagamori, Yoshihiko Kitaura, Masahiro Neya, Naohiro Matsushita
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Publication number: 20150336876Abstract: The invention provides a compound having a selective inhibitory activity against highly-expressed LAT-1 in tumor cell. The compound is represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, and a LAT-1 inhibitor comprising the same.Type: ApplicationFiled: January 21, 2014Publication date: November 26, 2015Inventors: Yoshikatsu KANAI, Shushi NAGAMORI, Yoshihiko KITAURA, Masahiro NEYA, Naohiro MATSUSHITA
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Patent number: 5036088Abstract: Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as antiallergy and antiinflammatory agents.Type: GrantFiled: December 3, 1990Date of Patent: July 30, 1991Assignee: Pfizer Inc.Inventors: Yoshihiko Kitaura, Fumitaka Ito, Rodney W. Stevens, Nobuko Asai
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Patent number: 5006541Abstract: Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as antiallergy and antiinflammatory agents.Type: GrantFiled: October 25, 1989Date of Patent: April 9, 1991Assignee: Pfizer Inc.Inventors: Yoshihiko Kitaura, Fumitaka Ito, Rodney W. Stevens, Nobuko Asai
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Patent number: 4904685Abstract: Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as antiallergy and antiinflammatory agents.Type: GrantFiled: February 27, 1989Date of Patent: February 27, 1990Assignee: Pfizer Inc.Inventors: Yoshihiko Kitaura, Fumitaka Ito, Rodney W. Stevens, Nobuko Asai
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Patent number: 4835166Abstract: Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as antiallergy and antiinflammatory agents.Type: GrantFiled: December 7, 1987Date of Patent: May 30, 1989Assignee: Pfizer Inc.Inventors: Yoshihiko Kitaura, Fumitaka Ito, Rodney W. Stevens, Nobuko Asai
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Patent number: 4801580Abstract: The invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R.sup.1 is hydrogen,R.sub.b.sup.1 is methyl,R.sup.2 is carboxy, carboxymethylcarbamoyl, 1-carboxyethylcarbamoyl or ethoxycarbonylmethylcarbamoyl,R.sup.q is carboxy or 3-t-butoxycarbonylcarbazoyl,R.sup.p is carboxy or methoxycarbonyl,R.sup.r is hydrogen, t-butoxycarbonyl or benzyloxycarbonyl,m is the integer 2, andn is the integer 1, or its pharmaceutically acceptable salt.Type: GrantFiled: May 13, 1982Date of Patent: January 31, 1989Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4749691Abstract: The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is hydroxyalkanoyl,R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy, R.sup. 2 is hydrogen or lower alkyl; R.sup.p is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3;or its pharmaceutically acceptable salt.Type: GrantFiled: April 13, 1987Date of Patent: June 7, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4725582Abstract: The invention concerns peptides, having the pharmaceutical property of enhancing the immune response, having the structure: ##STR1## wherein R.sup.1 is alkanoyl,R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl,R.sup.2 is hydrogen, carboxy, protected carboxy or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety is substituted by hydroxy or not substituted,R.sub.b.sup.2 is hydrogen or lower alkyl,R.sup.p is hydrogen, carboxy or protected carboxy,R.sup.q is carboxy, protected carboxy or a group of the formula ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above, R.sup.r is hydrogen or amino protective group,m is an integer 1 to 3, andn is an integer 1.Type: GrantFiled: May 13, 1982Date of Patent: February 16, 1988Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Takeno Hidekazu, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4698349Abstract: The invention relates to novel quinolizinone compounds, of inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is carboxy, carbamoyl Y.sup.1, phenylcarbamoyl which may have hydroxy, cyano or thiocarbamoyl,R.sup.7 is hydrogen or aryl selected from phenyl, tolyl, xylyl, cumenyl, naphthyl and biphenylyl;R.sup.2 is hydrogen, hydroxy, lower alkyl or lower alkoxy; andR.sup.Type: GrantFiled: August 30, 1985Date of Patent: October 6, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Teruo Oku, Hideo Hirai, Tosiyuki Yamamoto, Masashi Hashimoto
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Patent number: 4666890Abstract: The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is alkanoyl;R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.P is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group;m is an integer 1 to 3;or its pharmaceutically acceptable salt.Type: GrantFiled: May 20, 1982Date of Patent: May 19, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4650804Abstract: The invention relates to novel quinolizinone compounds having inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is tetrazolylcarbamoyl;R.sup.7 is hydrogen or aryl selected from phenyl, tolyl, xylyl, cumenyl, naphthyl and biphenylyl;R.sup.2 is hydrogen, hydroxy, lower alkyl or lower alkoxy;R.sup.Type: GrantFiled: March 18, 1985Date of Patent: March 17, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Teruo Oku, Hideo Hirai, Tosiyuki Yamamoto, Masashi Hashimoto
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Patent number: 4539155Abstract: The invention relates to compounds and salts of compounds which are diaminopimelyl peptides, N-acetoxypropionyl or N-t-butoxycarbonyl-amino-acid - (.alpha.-OBzl) glutamic acid peptides or N-acylated derivatives of (.alpha.-OBzl) glytamic acid or of (.alpha.-OBzl) aminoadipic acid.The compounds and their salts are starting materials for the preparation of pharmacologically active peptides.Type: GrantFiled: July 21, 1983Date of Patent: September 3, 1985Assignee: Fuisawa Pharmaceutical Company, Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4512980Abstract: The invention relates to novel peptides of pharmacological activity, of the formula ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy;R.sup.p is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 0;m is an interger 3; andn is an integer 1, provided that when R.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula:--CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.p is carboxy, or protected carboxy,R.sup.Type: GrantFiled: July 28, 1982Date of Patent: April 23, 1985Assignee: Fujisawa Pharmaceutical Co. Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto
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Patent number: 4504584Abstract: The invention relates to a biologically pure culture of new strains of the microorganism Streptomyces which are capable upon fermentation of producing a peptide of pharmacological activity.Type: GrantFiled: May 19, 1982Date of Patent: March 12, 1985Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4497729Abstract: This invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R.sup.1 is heptanoyl, stearoyl, 2-hydroxypropionyl or 2-acetoxypropionyl,R.sup.2 is hydrogen or methyl,R.sup.3 is carboxy, benzyloxycarbonyl or hydroxymethyl,R.sup.4 is hydrogen or methyl,R.sup.5 is carboxy or hydroxymethyl,R.sup.6 is carboxy, methoxycarbonyl, 3-t-butoxycarbonylcarbazoyl or hydroxymethyl,R.sup.7 is hydrogen, 3-t-butoxycarbonyl or benzyloxycarbonyl, andn is an integer 0 or 1, with the proviso that when each of R.sup.3 and R.sup.6 is not simultaneously hydroxymethyl, then R.sup.5 is hydroxymethyl.Type: GrantFiled: November 19, 1981Date of Patent: February 5, 1985Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Satoshi Yonishi, Hidekazu Takeno
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Patent number: 4493794Abstract: The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms, having the structure: ##STR1## wherein R.sup.1 is hydrogen, substituted or unsubstituted alkanoyl, or substituted or unsubstituted aralkanoyl,R.sup.2 is carboxy or protected carboxy,R.sup.3 is carboxy, protected carboxy, carbamoyl, or carboxy or protected carboxy(lower)alkylcarbamoyl,R.sup.4 is carboxy, protected carboxy or carbamoyl, andR.sup.5 is hydrogen or an amino protective group, with proviso that at least one of R.sup.3 and R.sup.4 is always carbamoyl and their pharmaceutically acceptable salts.Type: GrantFiled: December 9, 1981Date of Patent: January 15, 1985Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Satoshi Yonishi, Hidekazu Takeno, Satoshi Okada, Masashi Hashimoto
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Patent number: 4487763Abstract: The invention relates to novel peptides and their pharmaceutically acceptable salts, particularly useful for pharmaceutical purposes such as in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. The compounds have the structure ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy,R.sup. is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 2,m is an integer 0 to 2 andn is an integer 1, provided that, whenR.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula: --CONHR.sub.a.sup.2 wherein R.Type: GrantFiled: July 28, 1982Date of Patent: December 11, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto
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Patent number: RE32992Abstract: The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl;R.sup.2 is hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR3## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl or ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.p and R.sup.q are each hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy;R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3, and n is 1 .Iadd.provided that when R.sup.1 is benzyloxycarbonyl R.sub.5.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.Type: GrantFiled: May 18, 1984Date of Patent: July 18, 1989Assignee: Fujisawa Pharaceutical Co., Ltd.Inventors: Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka, Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto