Abstract: A high-strength steel sheet of the present invention has a specific chemical composition. Furthermore, in the steel sheet, a degree of Mn segregation in a specific region is 1.5 or less; a maximum P concentration in a specific region is 0.08 mass % or less; in a specific region, at least one specific MnS particle group is present, the number of specific MnS particle groups is 2.0 or fewer per 1 mm2, and the number of specific oxide-based inclusions is 8 or fewer per 1 mm2; of all oxide-based inclusions, oxide-based inclusions having a specific composition are present in a number ratio of 80% or greater; the microstructure includes, in terms of a volume fraction, 30 to 95% martensite, 5 to 70% ferrite phase, less than 30% (and 0% or greater) bainite, and less than 2.0% (and 0% or greater) austenite phase; and a tensile strength is 980 MPa or greater.

Abstract: Provided are a method for producing a complicated peptide molecule, such as a dimeric peptide, in a simpler manner at lower cost compared with the conventional chemical synthesis methods; and a dimeric peptide which comprises a specific short linker and has a satisfactory activity; and others.

Abstract: Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, or a salt thereof, are represented by the following Formula (I): A-L-B—R??(I) wherein A is an affinity substance to an antibody, L is a cleavable linker that is a divalent group comprising a cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is a reactive group to the antibody, wherein the affinity substance to an antibody is a polypeptide comprising a glutamine residue (Q) at an N-terminal.

Abstract: A novel technique for reducing the mis-cleavage of the TorA signal peptide, and thereby a method for efficient secretory production of a heterologous protein by a coryneform bacterium using a TorA signal peptide is provided. A coryneform bacterium having an ability of secretory production of a heterologous protein using a TorA signal peptide and has been modified so that the activity of a LepB protein is increased is cultured to produce the heterologous protein by secretory production.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria may include a method for secretory production of a heterologous protein. A coryneform bacterium having an ability of secretory production of a heterologous protein and has been modified so as to have a combination of two or more features from among the features (A), (B), and (C) is cultured to produce the heterologous protein by secretory production: (A) the activity of a RegX3 protein is reduced as compared with a non-modified strain; (B) the activity of an HrrSA system is reduced as compared with a non-modified strain; and (C) the activity of an HrcA protein is reduced as compared with a non-modified strain.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, and thereby a method for secretory production of a heterologous protein is provided. A coryneform bacterium able to secrete a heterologous protein modified so that the activity of RegX3 protein is reduced is cultured to produce the heterologous protein by secretory production.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, and thereby a method for secretory production of a heterologous protein is provided. A coryneform bacterium able to secrete a heterologous protein and modified so that the activity of HrrSA system is reduced is cultured to produce the heterologous protein by secretory production.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, as well as a method for secretory production of a heterologous protein. A coryneform bacterium is described that has been modified to have a specific mutation so as to harbor a phoS gene, and when cultured, is able to to produce a heterologous protein by secretory production.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, and thereby a method for secretory production of a heterologous protein is provided. A coryneform bacterium able to secrete a heterologous protein modified so that the activity of RegX3 protein is reduced is cultured to produce the heterologous protein by secretory production.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, and thereby a method for secretory production of a heterologous protein is provided. A coryneform bacterium able to secrete a heterologous protein and modified so that the activity of HrrSA system is reduced is cultured to produce the heterologous protein by secretory production.

Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, as well as a method for secretory production of a heterologous protein. A coryneform bacterium is described that has been modified to have a specific mutation so as to harbor a phoS gene, and when cultured, is able to to produce a heterologous protein by secretory production.

Abstract: A novel technique for improving ability for secretory production of a multimeric protein of a coryneform bacterium is provided, and thereby a method for secretory production of a multimeric protein is provided. A multimeric protein is produced by secretory production utilizing a coryneform bacterium having an ability to produce a multimeric protein by secretory production and modified so that expression of a gene coding for a metallopeptidase is increased as an expression host.

Abstract: A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that the activity of a penicillin-binding protein is reduced and in which the activity of a cell surface layer protein has been reduced as an expression host, a heterologous protein is produced by secretory production.

Abstract: A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that the activity of a penicillin-binding protein is reduced and in which the activity of a cell surface layer protein has been reduced as an expression host, a heterologous protein is produced by secretory production.

Abstract: A novel technique for improving ability for secretory production of a multimeric protein of a coryneform bacterium is provided, and thereby a method for secretory production of a multimeric protein is provided. A multimeric protein is produced by secretory production utilizing a coryneform bacterium having an ability to produce a multimeric protein by secretory production and modified so that expression of a gene coding for a metallopeptidase is increased as an expression host.

Abstract: A commutation type DC breaker comprising a main switch inserted in series into a main circuit for connecting a DC source and a load, a commutation capacitor, a reactor, and a commutation switch for supplying charges stored in the commutation capacitor to the main switch in an opposite direction to a main circuit current, producing a current zero point, thereby breaking the main switch, characterized in that the commutation capacitor, the reactor, and the commutation switch which are composed a commutation circuit and a control circuit for controlling the turning on or off of the main switch and the commutation switch are loaded on a frame with the main switch loaded.

Abstract: A circuit breaker includes a vacuum valve, an electromagnet including a first coil for driving an operating shaft of the vacuum valve toward an opening direction by electromagnetic repulsion, a movable core and a permanent magnet. Further, an operating mechanism is provided which excites the first coil to close the vacuum valve, holds the vacuum valve closed by an attractive force of the permanent magnet and excites the first coil in a direction reverse to an excitation direction in closing operation to open the vacuum valve. In the circuit breaker, together with the first coil, a second coil is disposed which is excited simultaneously with an electromagnetic repulsion coil for a quick opening operation by electromagnetic repulsion is provided in the electromagnet.

Abstract: A DC switchgear is provided with a commutation-type DC circuit breaker having a main circuit provided with a main switch for interconnecting a DC power supply and a load, and a commutating circuit provided with a commutating capacitor and a commutating switch, which is connected electrically parallel to the main switch. The switchgear further has a DC circuit breaker accommodating box that includes the main circuit provided with the main switch, and the commutation-type DC circuit breaker; a front accommodating box disposed on the front of the DC circuit breaker accommodating box, which accommodates devices having functions for controlling the switchgear and indicating a status, such as a failure status thereof; and a rear accommodating box disposed on the back of the DC circuit breaker accommodating box. The front and rear accommodating boxes are connected to the DC circuit breaker accommodating box to form an integrated DC switchgear.

Abstract: A commutation type DC breaker comprising a main switch inserted in series into a main circuit for connecting a DC source and a load, a commutation capacitor, a reactor, and a commutation switch for supplying charges stored in the commutation capacitor to the main switch in an opposite direction to a main circuit current, producing a current zero point, thereby breaking the main switch, characterized in that the commutation capacitor, the reactor, and the commutation switch which are composed a commutation circuit and a control circuit for controlling the turning on or off of the main switch and the commutation switch are loaded on a frame with the main switch loaded.

Abstract: A DC switchgear provided with a commutation-type DC circuit breaker having a main circuit provided with a main switch for interconnecting a DC power supply and a load and for enabling and disabling a main circuit current flow, and a commutating circuit provided with a commutating capacitor and a commutating switch, which is connected electrically parallel to the main switch, comprising: a DC circuit breaker accommodating box includes, as a standard arrangement, the main circuit provided with the main switch, and the commutation-type DC circuit breaker having the commutating circuit provided with the commutating capacitor and the commutating switch, which are connected electrically parallel to the main switch; a front accommodating box disposed on the front of the DC circuit breaker accommodating box, which accommodates devices having functions for controlling the switchgear and indicating a status of the switchgear including a failure status thereof; and a rear accommodating box disposed on the back of the DC