Abstract: Disclosed herein are methods and compositions for the treatment of age-related dysfunction, particularly, age-related motor impairment.

Abstract: A material which promotes ammonia metabolism in the body, as well as a material which has excellent ammonia metabolism improving effect and is effective for endurance enhancement and anti-fatigue are provided. An ammonia metabolism promoting agent, comprising catechins as an active ingredient. An agent for preventing or ameliorating hyperammonemia, hepatic encephalopathy or chronic fatigue syndrome, comprising catechins compound as an active ingredient. An ammonia metabolism promoting agent, an endurance enhancing agent and an anti-fatigue agent, comprising catechins, citrulline and arginine as active ingredients.

Abstract: A material which has excellent ammonia metabolism improving effect and is effective for endurance enhancement, anti-fatigue or the like is provided. An ammonia metabolism promoting agent, comprising catechins and ornithine as active ingredients. An endurance enhancing agent, comprising catechins and ornithine as active ingredients. An anti-fatigue agent, comprising catechins and ornithine as active ingredients. An agent for suppressing a reduction in blood glucose level by exercise, comprising catechins and ornithine as active ingredients. An agent for promoting recovery from reduced blood glucose level by exercise, comprising catechins and ornithine as active ingredients. An agent for suppressing a reduction in muscle glycogen by exercise, comprising catechins and ornithine as active ingredients. A muscle endurance enhancing agent, comprising catechins and ornithine as active ingredients.

Abstract: Provided is a tyrosine formulation excellent in bioabsorbability of tyrosine when ingested orally. An oral formulation with improved bioabsorbability of tyrosine, including glycyltyrosine or a salt thereof or a solvate thereof.

Abstract: A material which promotes ammonia metabolism in the body, as well as a material which has excellent ammonia metabolism improving effect and is effective for endurance enhancement and anti-fatigue are provided. An ammonia metabolism promoting agent, comprising catechins as an active ingredient. An agent for preventing or ameliorating hyperammonemia, hepatic encephalopathy or chronic fatigue syndrome, comprising catechins compound as an active ingredient. An ammonia metabolism promoting agent, an endurance enhancing agent and an anti-fatigue agent, comprising catechins, citrulline and arginine as active ingredients.

Abstract: Provided is a tyrosine formulation excellent in bioabsorbability of tyrosine when ingested orally. An oral formulation with improved bioabsorbability of tyrosine, including glycyltyrosine or a salt thereof or a solvate thereof.

Abstract: A material which has excellent ammonia metabolism improving effect and is effective for endurance enhancement, anti-fatigue or the like is provided. An ammonia metabolism promoting agent, comprising catechins and ornithine as active ingredients. An endurance enhancing agent, comprising catechins and ornithine as active ingredients. An anti-fatigue agent, comprising catechins and ornithine as active ingredients. An agent for suppressing a reduction in blood glucose level by exercise, comprising catechins and ornithine as active ingredients. An agent for promoting recovery from reduced blood glucose level by exercise, comprising catechins and ornithine as active ingredients. An agent for suppressing a reduction in muscle glycogen by exercise, comprising catechins and ornithine as active ingredients. A muscle endurance enhancing agent, comprising catechins and ornithine as active ingredients.

Abstract: A method for enhancing endurance and/or for removing fatigue by administering to a subject in need thereof a composition containing an effective amount of nootkatone. The method may be further combined with exercise.

Abstract: Provision of a pharmaceutical product, a quasi-drug, a food, a beverage, a pet food, a feed, and others which are highly safe, have excellent action of promoting energy consumption, promoting fat burning, promoting carbohydrate burning, or improving an effect of exercise, and which are effective for the prevention or amelioration of obesity or metabolic syndrome or the improvement of motor functions. An agent for promoting energy consumption, an agent for promoting fat burning, an agent for promoting carbohydrate burning, an agent for improving an effect of exercise, an agent for improving motor functions, an agent for inhibiting acetyl-CoA carboxylase 2, and an agent for inhibiting pyruvate dehydrogenase kinase 4 containing chlorogenic acids or salts thereof as an active ingredient.

Abstract: A method for enhancing endurance and/or for removing fatigue by administering to a subject in need thereof a composition containing an effective amount of nootkatone. The method may be further combined with exercise.

Abstract: To provide an endurance improver, anti-fatigue agent and anti-aging agent having an ingredient taken for long years as a food, having high safety, easily available, and excellent in processability. An endurance improver, anti-fatigue agent, muscle strength improver, motor performance enhancer and anti-aging agent containing resveratrol and/or grape leaf extract as an effective ingredient.

Abstract: The present invention relates to provision of AMPK activating agent, endurance enhancing agent, and antifatigue agent, which have rich history of use in foods, high safety, readily available, and high workability, a method of activating AMPK, and a method of preventing, treating and/or ameliorating a life-style-related disease. The present invention provides AMPK activating agent, endurance enhancing agent, and antifatigue agent, each of which contains nootkatone as an active agent. The present invention provides a method of activating AMPK characterized by administering nootkatone in an effective amount, and a method of preventing, treating and/or ameliorating a life-style-related disease characterized by administering nootkatone in an effective amount.