Abstract: A high-strength steel sheet of the present invention has a specific chemical composition. Furthermore, in the steel sheet, a degree of Mn segregation in a specific region is 1.5 or less; a maximum P concentration in a specific region is 0.08 mass % or less; in a specific region, at least one specific MnS particle group is present, the number of specific MnS particle groups is 2.0 or fewer per 1 mm2, and the number of specific oxide-based inclusions is 8 or fewer per 1 mm2; of all oxide-based inclusions, oxide-based inclusions having a specific composition are present in a number ratio of 80% or greater; the microstructure includes, in terms of a volume fraction, 30 to 95% martensite, 5 to 70% ferrite phase, less than 30% (and 0% or greater) bainite, and less than 2.0% (and 0% or greater) austenite phase; and a tensile strength is 980 MPa or greater.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A range imaging apparatus includes a light illuminator that emits signal light from a light source toward a subject; a light receiver that receives light reflecting off the subject; a range image generator that calculates a distance value to the subject based on a time difference between emission and light reception, and generates a range image; a distance value distribution analyzer that calculates a distribution characteristic of the distance value calculated by the range image generator; an illumination controller that adjusts output of the light illuminator; an exposure controller that adjusts exposure by the light receiver; and a signal adjuster that adjusts the illumination controller and the exposure controller based on the distribution characteristic. The signal adjuster adjusts at least one of the illumination controller and the exposure controller for the second signal light based on the distribution characteristic obtained through emission and light reception of the first signal light.

Abstract: A range imaging apparatus includes a light illuminator that emits signal light from a light source toward a subject; a light receiver that receives light reflecting off the subject; a range image generator that calculates a distance value to the subject based on a time difference between emission and light reception, and generates a range image; a distance value distribution analyzer that calculates a distribution characteristic of the distance value calculated by the range image generator; an illumination controller that adjusts output of the light illuminator; an exposure controller that adjusts exposure by the light receiver; and a signal adjuster that adjusts the illumination controller and the exposure controller based on the distribution characteristic. The signal adjuster adjusts at least one of the illumination controller and the exposure controller for the second signal light based on the distribution characteristic obtained through emission and light reception of the first signal light.