Abstract: Means which enables preparation of a thick cell aggregate by a simple process without an operation of detaching and stacking of cells is disclosed. The method for preparing a three-dimensional cell aggregate by the present invention comprises: a cell encasing step of placing a cell suspension in a cell container; and a pressure application step of applying pressure to cells in the container. The cell encasing step and the pressure application step may be carried out a plurality of times. By the present invention, a thick, robust cell aggregate can be obtained by a simple operation of applying pressure to a cell suspension or a medium containing cells. Since the method does not require an operation of stacking a plurality of cell sheets, the cells are hardly damaged, and the conditions of the cells can be favorably maintained, so that the cells can be advantageously used as a tissue piece for transplantation.

Abstract: A battery pack (30) is configured to couple to a power tool (10) by sliding in a sliding direction and it contains a plurality of cells (31). A pair of battery-side, electric-power terminals (312a, 312b, 314a, 314b) and a battery-side signal terminal (313) can be electrically connected to a pair of tool-side, power-supply terminals (212, 214) and a tool-side signal terminal (213), respectively, which are provided on the power tool (10). The pair of battery-side, electric-power terminals (312a, 312b, 314a, 314b) and the battery-side signal terminal (313) are disposed in parallel adjacently in a direction that intersects the sliding direction.

Abstract: A power supply apparatus includes a power supply configured to apply an alternating current to a magnetic field generation apparatus; and a controller configured to control the alternating current applied by the power supply. The controller controls the power supply to apply the alternating current having a waveform pattern including a plurality of current waveforms having different frequency spectrums from each other.

Abstract: A cancer treatment apparatus including a magnetic field generator that generates a magnetic field of 100 kHz to 300 kHz to be applied to affected tissues.

Abstract: A battery pack (30) is configured to couple to a power tool (10) by sliding in a sliding direction and it contains a plurality of cells (31). A pair of battery-side, electric-power terminals (312a, 312b, 314a, 314b) and a battery-side signal terminal (313) can be electrically connected to a pair of tool-side, power-supply terminals (212, 214) and a tool-side signal terminal (213), respectively, which are provided on the power tool (10). The pair of battery-side, electric-power terminals (312a, 312b, 314a, 314b) and the battery-side signal terminal (313) are disposed in parallel adjacently in a direction that intersects the sliding direction.

Abstract: A battery pack (30) is configured to couple to a power tool (10) by sliding in a sliding direction and it contains a plurality of cells (31). A pair of battery-side, electric-power terminals (312a, 312b, 314a, 314b) and a battery-side signal terminal (313) can be electrically connected to a pair of tool-side, power-supply terminals (212, 214) and a tool-side signal terminal (213), respectively, which are provided on the power tool (10). The pair of battery-side, electric-power terminals (312a, 312b, 314a, 314b) and the battery-side signal terminal (313) are disposed in parallel adjacently in a direction that intersects the sliding direction.

Abstract: In a guide vane according to an embodiment of the invention, where in a section perpendicular to a guide vane rotation axis, a curvature of a contour line forming a runner side vane surface of the guide vane is referred to as a positive curvature when the contour line is formed to be convex, while the curvature of the contour line is referred to as a negative curvature when the contour line is formed to be concave, a negative curvature portion where the curvature of the contour line becomes negative is provided on the runner side vane surface. The negative curvature portion is formed from an upper end portion to a lower end portion of the runner side vane surface.

Abstract: Novel means capable of detecting an arteriosclerotic lesion in a body by a less invasive, simple method is disclosed. The method for detecting arteriosclerosis according to the present invention comprises measuring the myosin heavy chain 11 level in a blood sample isolated from a subject. A myosin heavy chain 11 level higher than that of a healthy individual is indicative of the presence of arteriosclerosis in the subject. Since the present invention enables detection of arteriosclerosis by a blood test, a less invasive, simple test can be carried out. Unlike methods for testing only particular regions such as carotid artery ultrasonography, the present invention is expected to reflect the conditions of blood vessels in the whole body.

Abstract: A system capable of designing an optimum administration form of a magnetic drug is provided. The system determines first information about an side-effect-related organ on which a magnetic drug produces a side effect, based on equipment analysis information after administering the magnetic drug; further determines second information about a drug-efficacy-related organ in which drug efficacy of the magnetic drug should be demonstrated; evaluates the administration form of the magnetic drug based on the first information and the second information; corrects the administration form of the magnetic drug based on an evaluation result; and outputs information of the corrected administration form.

Abstract: A water-tree resistance evaluation material including: a material selection selecting a candidate insulation material; a test carrying out a water tree test on a test piece having electrode holes formed on a first surface; and a candidate insulation material evaluation evaluating characteristics of the candidate insulation material, including progress and speed of a water tree. The test includes: a system and condition setting for setting a test system; a voltage application for grounding a ground-side electrode that is immersed in the ground-side aqueous solution, while applying an AC voltage to an application-side electrode that is immersed in the application-side aqueous solution; a measurement step; and a period determination for determining whether a test period has exceeded a predetermined period.

Abstract: The present invention provides a drug delivery system that overcomes conventional technical problems and that is readily put to practical use. Iron-salen complexes represented by General Formula (I) below. The invention renders iron-salen complexes magnetic, which can thus be used as drugs that can be delivered to affected areas in the body using the inherent magnetic properties of the drug without employing carriers composed of magnetic substances as has been done hitherto.

Abstract: A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing this metal-salen complex compound, and an antineoplastic drug containing this metal-salen complex compound are provided. Regarding the metal-salen complex compound, a metal atom part in each of two molecules of a metal-salen complex or a derivative of the metal-salen complex is dimerized via water, and the metal-salen complex compound is mixed with a base to produce an ointment.

Abstract: An encapsulated agent includes: a central part 1; and an outer part 2 that covers a surface of the central part 1. The central part 1 contains a viscosity-reducing material that reduces the viscosity of a fluid to be used in a hydrofracturing technique. The outer part 2 enables gradual release of the central part 1 in the fluid, and contains a styrene-butadiene copolymer having glass-transition temperature that is equal to or higher than ?20 degrees centigrade and equal to or lower than 80 degrees centigrade.

Abstract: [Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a complex produced by making a metal-salen complex compound, which includes a central metal and (N, N, O, O) as a quadridentate ligand and is magnetic, bind to taxane molecules which are anticancerous; and the anticancer agent is to kill cancer cells regarding which phase transition of its cell cycle occurs between phases including Gap1, Synthesis, Gap2, and Mitosis and Cytokinesis. The present disclosure is suited for use to kill cancer cells of breast cancer and, particularly, cancer cells of triple-negative breast cancer. The present disclosure is designed to make the anticancer agent contact the cancer cells in two or more continuous phases selected from a group consisting of Gap1, Synthesis, Gap2, and Mitosis and Cytokinesis and kill the cancer cells.

Abstract: A battery charger in one aspect of the present disclosure comprises a charging unit, a first voltage detector, a second voltage detector, and a determination unit. The determination unit determines that there is an abnormality in at least one of a charge path or a detection path when an absolute value of a difference between a voltage of a battery detected by the first voltage detector and a voltage of the battery detected by a second voltage detector is equal to or greater than a threshold value.

Abstract: [object] A magnetization technique that enhances magnetic properties of an organic compound is provided without damaging properties of the organic compound or while maintaining the structure of the organic compound. [solution] The present disclosure is a method for manufacturing a magnetic substance composed of crystals of a magnetization target compound and an electron acceptor by combining the magnetization target compound with the electron acceptor; forming a solution by dissolving a mixture of the magnetization target compound and the electron acceptor in a solvent; maintaining the solution in a very low temperature state and allowing the solution to deposit the crystals of the magnetic target compound and the electron acceptor; and separating the crystals from the solvent.

Abstract: [Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a complex produced by making a metal-salen complex compound, which includes a central metal and (N, N, O, O) as a quadridentate ligand and is magnetic, bind to taxane molecules which are anticancerous; and the anticancer agent is to kill cancer cells regarding which phase transition of its cell cycle occurs between phases including Gap1, Synthesis, Gap2, and Mitosis and Cytokinesis. The present disclosure is suited for use to kill cancer cells of breast cancer and, particularly, cancer cells of triple-negative breast cancer. The present disclosure is designed to make the anticancer agent contact the cancer cells in two or more continuous phases selected from a group consisting of Gap1, Synthesis, Gap2, and Mitosis and Cytokinesis and kill the cancer cells.

Abstract: Means which enables preparation of a thick cell aggregate by a simple process without an operation of detaching and stacking of cells is disclosed. The method for preparing a three-dimensional cell aggregate by the present invention comprises: a cell encasing step of placing a cell suspension in a cell container; and a pressure application step of applying pressure to cells in the container. The cell encasing step and the pressure application step may be carried out a plurality of times. By the present invention, a thick, robust cell aggregate can be obtained by a simple operation of applying pressure to a cell suspension or a medium containing cells. Since the method does not require an operation of stacking a plurality of cell sheets, the cells are hardly damaged, and the conditions of the cells can be favorably maintained, so that the cells can be advantageously used as a tissue piece for transplantation.

Abstract: A metal-salen complex derivative with an excellent yield and stability is provided and a method for producing such a metal-salen complex derivative is provided. The present invention provides: metal-salen complex derivative obtained by allowing a target component composed of at least one of an enzyme, an antibody, an antigen, a peptide, an amino acid, an oligonucleotide, a protein, a nucleic acid, and a medical molecule to bind to a metal-salen complex via an amide bond or a disulfide bond; a method for producing such a metal-salen complex derivative.

Abstract: A new self-magnetic metal-salen complex compound and its derivatives are provided. The present invention is a metal-salen complex compound including any one of the following compounds.