Patents by Inventor Yoshihiro Kozuki

Yoshihiro Kozuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compound
    Patent number: 8912180
    Abstract: Provided is a novel compound which is an agent for treating rejection reactions in various organ transplantations, allergy diseases, autoimmune diseases, and hematologic tumor, and based on a PI3K? selective inhibitory action and/or an IL-2 production inhibitory action and/or a B cell proliferation inhibitory action (including an activation inhibitory action). The provided compound has a PI3K? selective inhibitory action, an IL-2 production inhibitory action, and/or a B cell proliferation inhibitory action, including an activation inhibitory action.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: December 16, 2014
    Assignee: Astellas Pharma Inc.
    Inventors: Fumie Takahashi, Sunao Imada, Toru Asano, Yoshihiro Kozuki, Junko Maeda, Koji Kato, Hidehiko Fukahori, Masahiko Shiwaku
  • FUSED HETEROCYCLES AS LCK INHIBITORS
    Publication number: 20100216798
    Abstract: There is provided fused heterocycles of imidazopyridazine or pyrazolopyrimidine derivative represented by the formula (I), which have excellent Lck inhibitory activity and are useful for a medicament particularly an immunosuppressive agent. [wherein one of Y and Z is C atom, and the other is N atom; —X— is —N(R1)— or the like, —R1 represents hydrogen or the like, -A- represents bond or the like, —R2 is cycloalkyl, aryl or the like, -E- is bond or the like, —R3 is aryl, aromatic heterocycle or the like, —R4, —R5 and —R6 are the same or different, each being hydrogen or the like.
    Type: Application
    Filed: July 27, 2006
    Publication date: August 26, 2010
    Applicant: ASTELLAS PHARMA INC
    Inventors: Kazuo Nakai, Fumie Takahashi, Kazuya Fujita, Yoshihiro Kozuki, Koichiro Mukoyoshi, Masamichi Inami, Norio Asai
  • Pyrazinyl hydroxyacrylamide compounds having an inhibitory effect on the activity of histone deacetylase
    Patent number: 7750155
    Abstract: This invention relates to novel N-hydroxyacrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof. More particularly, it relates to novel N-hydroxyacrylamide compounds and pharmaceutically acceptable salts thereof which act as a HDAC inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of HDAC-related disease.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: July 6, 2010
    Assignee: Astellas Pharma Inc.
    Inventors: Fumiyuki Shirai, Hideo Tsutsumi, Hiromichi Itani, Yoshihiro Kozuki, Yoshiteru Eikyu, Taro Masunaga
  • N-HYDROXYACRYLAMIDE COMPOUNDS
    Publication number: 20090054465
    Abstract: This invention relates to novel N-hydroxyacrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof. More particularly, it relates to novel N-hydroxyacrylamide compounds and pharmaceutically acceptable salts thereof which act as a HDAC inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of HDAC-related disease.
    Type: Application
    Filed: February 6, 2007
    Publication date: February 26, 2009
    Applicant: Astella Pharma Inc.
    Inventors: Fumiyuki Shirai, Hideo Tsutsumi, Hiromichi Itani, Yoshihiro Kozuki, Yoshiteru Eikyu, Taro Masunaga