Abstract: A differential amplifier circuit is provided with an operational amplifier and a modulator. The operational amplifier includes a feedback capacitance, and amplifies an analog input signal and outputs an amplified analog output signal. The modulator is connected to a virtual ground point of an input terminal of the operational amplifier, and the modulator switches between a pair of inputted analog differential signals to alternately select one of the analog differential signals based on a predetermined modulation control signal, and outputs a selected analog differential signal. The differential amplifier circuit alternately folds and amplifies the analog input signal within a predetermined input level limit range to generate a signal having different polarities sequentially so as to start from a voltage potential of the virtual ground point at a timing of the modulation control signal. In addition, an converter apparatus is provided with the differential amplifier circuit.

Abstract: A differential amplifier circuit is provided with an operational amplifier and a modulator. The operational amplifier includes a feedback capacitance, and amplifies an analog input signal and outputs an amplified analog output signal. The modulator is connected to a virtual ground point of an input terminal of the operational amplifier, and the modulator switches between a pair of inputted analog differential signals to alternately select one of the analog differential signals based on a predetermined modulation control signal, and outputs a selected analog differential signal. The differential amplifier circuit alternately folds and amplifies the analog input signal within a predetermined input level limit range to generate a signal having different polarities sequentially so as to start from a voltage potential of the virtual ground point at a timing of the modulation control signal. In addition, an converter apparatus is provided with the differential amplifier circuit.

Abstract: In a feedback amplifier circuit, a first switching device executes an auto-zero operation by inputting a signal outputted from an amplifier to an input terminal of the amplifier during an auto-zero operation interval prior to an amplification interval. A first capacitor accumulates and holds an offset voltage at the output terminal of the amplifier during the auto-zero operation interval, and cancels an offset voltage at the input terminal of the amplifier by an accumulated and held offset voltage during an amplification interval subsequent to the auto-zero operation interval. A second switching device grounds the feedback point of the feedback circuit during the auto-zero operation interval. A second capacitor blocks a DC voltage, and accumulates and holds an offset voltage at an output terminal of the amplifier, and cancels an offset voltage at an input terminal of the amplifier by the accumulated and held offset voltage during an amplification interval.

Abstract: In a feedback amplifier circuit, a first switching device executes an auto-zero operation by inputting a signal outputted from an amplifier to an input terminal of the amplifier during an auto-zero operation interval prior to an amplification interval. A first capacitor accumulates and holds an offset voltage at the output terminal of the amplifier during the auto-zero operation interval, and cancels an offset voltage at the input terminal of the amplifier by an accumulated and held offset voltage during an amplification interval subsequent to the auto-zero operation interval. A second switching device grounds the feedback point of the feedback circuit during the auto-zero operation interval. A second capacitor blocks a DC voltage, and accumulates and holds an offset voltage at an output terminal of the amplifier, and cancels an offset voltage at an input terminal of the amplifier by the accumulated and held offset voltage during an amplification interval.

Abstract: In a chopper amplifier circuit operable at a low voltage utilizing a switched operational amplifier, a chopper modulator chopper-modulates an input signal according to a predetermined control signal, and outputs a chopper-modulated signal. An amplifier circuit constituted by the switched operational amplifier amplifies the chopper-modulated signal outputted from the chopper modulator, and outputs an amplified chopper-modulated signal. A chopper-demodulator of the switched operational amplifier chopper-demodulates the amplified chopper-modulated signal outputted from the amplifier circuit according to the control signal, and outputs a demodulated output signal as a chopper-amplified output signal from an output terminal. A chopper modulator chopper-modulates a demodulated signal outputted from the chopper demodulator according to the control signal, and outputs a chopper-modulated signal to an input terminal of the amplifier circuit.

Abstract: In a chopper amplifier circuit operable at a low voltage utilizing a switched operational amplifier, a chopper modulator chopper-modulates an input signal according to a predetermined control signal, and outputs a chopper-modulated signal. An amplifier circuit constituted by the switched operational amplifier amplifies the chopper-modulated signal outputted from the chopper modulator, and outputs an amplified chopper-modulated signal. A chopper-demodulator of the switched operational amplifier chopper-demodulates the amplified chopper-modulated signal outputted from the amplifier circuit according to the control signal, and outputs a demodulated output signal as a chopper-amplified output signal from an output terminal. A chopper modulator chopper-modulates a demodulated signal outputted from the chopper demodulator according to the control signal, and outputs a chopper-modulated signal to an input terminal of the amplifier circuit.

Abstract: The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

Abstract: A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and GPT activities in blood which are markers of liver diseases, and also suppresses symptoms such as choloplania.

Abstract: The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

Abstract: An improved two-split carrying barge according to the present invention is aimed at solving the problem of ensuring watertightness at the opening portion of a hold of the barge. The carrying barge of the present invention has left and right parts of a hull that are rotated through hinges to open or close the hold at the bottom of the barge. The left and right parts of the hull are positively coupled by a coupling device which can be released with great ease by remote control when loaded cargo is to be expelled from the hold of the barge. Moreover, the carrying barge of the present invention is equipped with a rubber packing arrangement at the opening portion between the left and right parts of the hull. Since the rubber packing arrangement can flexibly cope with a change in the width of the opening portion due to rolling or pitching, the watertightness of the carrying barge of the present invention is ensured.

Abstract: Methods and compositions are provided for regulated expression of polypeptides in transformed bacterial hosts. A novel class of plasmid cloning vehicles includes a DNA sequence coding for the desired polypeptide (or an insertion site therefor) linked for transcriptional expression in reading phase with one or more functional fragments derived from an outer membrane protein gene of a Gram-negative bacterium. The plasmids also include an inducible promoter sequence positioned in the proper orientation for transcriptional expression of the desired polypeptide, as well as a separate DNA sequence coding for a repressor molecule which can interact with the inducible promoter to prevent transcription therefrom. Expression of the desired polypeptide is under the control of both the constitutive promoter and the inducible promoter, although transcription from either promoter is normally blocked by the repressor molecule.

Abstract: Methods and compositions are provided for regulated expression and secretion of polypeptides in transformed bacterial hosts. A novel class of plasmid cloning vehicles includes a DNA sequence coding for the desired polypeptide (or an insertion site therefor) linked for transcriptional expression in reading phase with four functional fragments derived from the lipoprotein gene of E. coli. The plasmids also include a DNA fragment coding for the signal peptide of the ompA protein of E. coli, positioned such that the desired polypeptide is expressed with the ompA signal peptide at its amino terminus, thereby allowing efficient secretion across the cytoplasmic membrane. The plasmids further include a DNA sequence coding for a specific segment of the E. coli lac promoter-operator, which is positioned in the proper orientation for transcriptional expression of the desired polypeptide, as well as a separate functional E.

Abstract: Methods and compositions are provided for regulated expression of polypeptides in transformed bacterial hosts. A novel class of plasmid cloning vehicles includes a DNA sequence coding for the desired polypeptide (on an insertion site therefor) linked for transcriptional expression in reading phase with four functional fragments derived from the lipoprotein gene of E. coli. The plasmids further include a DNA sequence coding for a specific segment of the E. coli lac promoter-operator, which is positioned in the proper orientation for transcriptional expression of the desired polypeptide, as well as a separate functional E. coli lacI gene coding for the associated repressor molecule which can interact with the lac promoter-operator to prevent transcription therefrom. Expression of the desired polypeptide is under the control of both the constitutive promoter and the inducible promoter, although transcription from either promotor is normally blocked by the repressor molecule.