Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).

Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).

Abstract: Problem to be Solved To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity. Solution The present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

Abstract: A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof.

Abstract: The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group.

Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).

Abstract: Problem to be Solved To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity. Solution The present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

Abstract: A method of detecting a reactive metabolite which comprises steps of conducting a metabolic reaction of a test compound in the presence of two labeled nucleophiles, and detecting the label of the nucleophiles bound to the reactive metabolite, and a method of detecting a reactive metabolite which further comprises separating liquid layer using ammonium acetate to obtain an organic layer after the aforementioned reaction step are disclosed. In these detection methods, a reactive metabolite can be quantitatively detected by easy preparation. Furthermore, generation of a false positive signal can be prevented, and generation of a false negative signal can be decreased. Accordingly, screening of a test compound can be efficiently performed with higher accuracy.

Abstract: Novel compounds having excellent PPAR ?/? agonist effects and having desirable properties for medicaments are provided. Peroxisome proliferator-activated receptor ?/? agonists of the general formula (I): (wherein Q is an optionally-substituted benzene or pyridine ring; R1 and R2 each are an optionally-substituted phenyl group or 5- or 6-membered aromatic heterocyclic group; X Y, and Z are independently C, O, S or N; R3 to R9 each are a hydrogen atom, a lower alkyl group, etc.; n is an integer of 0 to 3).

Abstract: An optical modulation method operable in an optical transmission path using an optical fiber, wherein an optical fiber bending region is formed by bending a portion of the optical fiber into a U shape having a predetermined bending width. A bending width set point is set in correspondence with a predetermined inclined portion of a characteristic curve representing a dependency ratio of insertion loss of light propagating in said optical fiber bending region relative to the bending width thereof, said predetermined inclined portion of said characteristic curve being located between a predetermined maximum and minimum portion thereof. Intensity modulation of light propagating in the optical fiber is performed using a signal to be transmitted by adjusting the bending width of the optical fiber bending region in correspondence with the signal to be transmitted with reference to the bending width set point as a center.

Abstract: An optical modulation method operable in an optical transmission path using an optical fiber, wherein an optical fiber bending region is formed by bending a portion of the optical fiber into a U shape having a predetermined bending width. A bending width set point is set in correspondence with a predetermined inclined portion of a characteristic curve representing a dependency ratio of insertion loss of light propagating in said optical fiber bending region relative to the bending width thereof, said predetermined inclined portion of said characteristic curve being located between a predetermined maximum and minimum portion thereof. Intensity modulation of light propagating in the optical fiber is performed using a signal to be transmitted by adjusting the bending width of the optical fiber bending region in correspondence with the signal to be transmitted with reference to the bending width set point as a center.

Abstract: In a video tape recorder and/or reproducer, the power of a capstan motor for driving a magnetic tape is utilized as the power for driving reels in a cassette. In order to facilitate controlling the tension of the magnetic tape at the time of a change in the travelling direction of the tape in an intermittent tape travel mode, it is possible to drive a feed-side reel without turning OFF a back tension servo mechanism which applies back tension to the feed-side reel. In this state, the change in the travelling direction of the magnetic tape is performed by only controlling the direction of rotation of the capstan motor.

Abstract: Grooves are formed on the armor portion of a magnetic head. Elastic pieces having nails for linking to the grooves of the head, and a concave portion for positioning the head are integrally molded with a mounting arm for mounting the head. Linkage of the head to the mounting arm is achieved by the linkage of the elastic pieces to the grooves.

Abstract: An automatic cassette loading apparatus in which a tape cassette containing a magnetic tape is held and transported forwardly and returned between a cassette insertion position and a cassette loaded position. The number of switches is reduced by use of a rotary cam and a drive arm, and a drive motor and the switches are combined on the same printed circuit board.

Abstract: A light-emitting element and light-receiving elements are embedded upright in a single printed wiring board for cooperating with one another in detecting the leader tape portion of a magnetic tape. Such a printed wiring board is fixed to a chassis by means of which a magnetic tape cassette is held in position. This arrangement enables a reduction in the number of leads and connectors, and hence greatly decreases the number of connections to the body of a magnetic recording and reproducing apparatus, thereby improving its adaptability with respect to automated assembly.

Abstract: A cassette loading mechanism of a magnetic recording and/or reproducing apparatus including: a cassette holder for accommodating a tape cassette; a bracket having a guide slit along which the cassette holder is guided from a first position to a second position, the bracket accommodating the cassette holder; a cassette holder driving mechanism for driving the cassette holder along the guide slit formed in the bracket, the cassette holder driving mechanism including cassette holder driving arm disposed between the cassette holder and the bracket and connected to the cassette holder; a power source; and a power transmitting means for driving the cassette holder driving arm while being supplied with power from the power source.

Abstract: In a cassette loading apparatus for a video tape recorder equipped with a front loading mechanism, bearing portions of a worm are disposed at predetermined positions in side brackets for supporting a cassette holder which have L-shaped guide holes for guiding the support shaft of the cassette holder in both horizontal and vertical directions, a reference hole is bored on the base of the video tape recorder, a shaft of the worm is inserted through the bearing portions and the reference hole, and the worm shaft keeps constant the axial distance between gears for a cassette loading mechanism and a driving gear for driving the video tape recorder.

Abstract: A method of operating an air-supplied type coating booth in which conditioned air supplied from an air supply blower is enforced downwardly to the inside of a tunnel-shaped coating booth and the air in the coating booth is drawn together with paint mists and the likes down to the beneath of a booth floor by way of an air exhaust blower comprises the steps of detecting the flow velocity of air streams flowing into or out of inlet and the exit of the coating booth, applying primary and secondary averaging processings for signals for averaging variations caused by external disturbances fluctuating at relatively shorter and longer periods of time, judging the thus averaged direction and the flow velocity of the air streams at the inlet and the exit, variably controlling the flow rate of exhaust from the exhaust blower in accordance with the direction and the flow velocity.

Abstract: A method of operating an air-supplied type coating booth in which conditioned air is enforced from an air supply blower downwardly to the inside of a coating booth and then discharged to the beneath of the booth floor by an exhaust blower, in which the booth operation is stopped after memorizing the balanced flow rates for the supply blower and the exhaust blowers kept just before the completion of the booth operation, and the supply blower and the exhaust blower are automatically set to the above-mentioned balanced flow rates respectively upon re-starting the booth operation again. Balanced and stable booth operation where no air streams flow into or out of the inlet and the exit can be attained rapidly at the start of the booth operation.

Abstract: A method of operating an air-supplied type coating booth adapted to enforce conditioned air by an air supply blower through a filter downwardly to the inside of a tunnel-shaped coating booth at a predetermined flow velocity and then drawn to discharge together with coating mists, etc. to the beneath of the floor comprises the step of detecting the flow velocity of conditioned air flowing through the filter to the inside of continuously, applying primary and secondary averaging processings for the detected signals containing variations fluctuating at relatively shorter and longer periods respectively, comparing the value obtained from the signals applied with the secondary averaging processing with a predetermined flow velocity value and variably controlling the flow rate of the air supplied from the air supply blower depending on the deviation and thereby maintaining the flow velocity of the conditioned air flowing to the inside of the coating booth always constant.