Patents by Inventor Yoshihiro Tampo

Yoshihiro Tampo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyaluronic acid derivative having amino acid and steryl group introduced thereinto
    Patent number: 11564971
    Abstract: The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: January 31, 2023
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takashi Nakai, Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tsuyoshi Shimoboji
  • SELF-EMULSIFYING DRUG FORMULATION FOR IMPROVING MEMBRANE PERMEABILITY OF COMPOUND
    Publication number: 20220096379
    Abstract: An objective of the present invention is to provide lymphatically-transported self-emulsifying formulations for enhancing membrane permeability of poorly membrane-permeable compounds in oral administration of the compounds. It was discovered that by applying lymphatically-transported self-emulsifying formulations containing a surfactant containing oleic acid as a moiety or oily component to poorly membrane-permeable compounds containing a cyclic peptide and having features (i) and (ii) below, the membrane permeability and absorbability of the compounds can be improved: (i) log D (pH 7.4) value of the compounds is 3.2 or greater; and (ii) Caco-2 Papp (cm/sec) value of the compounds is 1.8E-6 or less.
    Type: Application
    Filed: October 15, 2021
    Publication date: March 31, 2022
    Inventors: Yoshihiro TAMPO, Ryusuke Takano, Nozomi Hisada, Kenichi Sakai, Kazuhisa Ozeki, Yuji Sakurai, Atsuko Higahida
  • SELF-EMULSIFYING DRUG FORMULATION FOR IMPROVING MEMBRANE PERMEABILITY OF COMPOUND
    Publication number: 20190380958
    Abstract: An objective of the present invention is to provide lymphatically-transported self-emulsifying formulations for enhancing membrane permeability of poorly membrane-permeable compounds in oral administration of the compounds. It was discovered that by applying lymphatically-transported self-emulsifying formulations containing a surfactant containing oleic acid as a moiety or oily component to poorly membrane-permeable compounds containing a cyclic peptide and having features (i) and (ii) below, the membrane permeability and absorbability of the compounds can be improved: (i) log D (pH 7.4) value of the compounds is 3.2 or greater; and (ii) Caco-2 Papp (cm/sec) value of the compounds is 1.8E-6 or less.
    Type: Application
    Filed: December 27, 2017
    Publication date: December 19, 2019
    Inventors: Yoshihiro TAMPO, Ryusuke TAKANO, Nozomi HISADA, Kenichi SAKAI, Kazuhisa OZEKI, Yuji SAKURAI, Atsuko HIGASHIDA
  • Derivative of hyaluronic acid modified with amino-carboxylic acid
    Patent number: 9243077
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: January 26, 2016
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji
  • HYALURONIC ACID DERIVATIVE HAVING AMINO ACID AND STERYL GROUP INTRODUCED THEREINTO
    Publication number: 20150231268
    Abstract: The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.
    Type: Application
    Filed: September 5, 2013
    Publication date: August 20, 2015
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takashi Nakai, Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tsuyoshi Shimoboji
  • DERIVATIVE OF HYALURONIC ACID MODIFIED WITH AMINO-CARBOXYLIC ACID
    Publication number: 20130338352
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 19, 2013
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji