Patents by Inventor Yoshihiro Tokudome

Yoshihiro Tokudome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triterpenic acid derivative and preparation for external application for skin comprising the same
    Patent number: 7718635
    Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: May 18, 2010
    Assignee: Pola Chemical Industries Inc.
    Inventors: Michio Ochiai, Kenichi Goto, Yoshihiro Tokudome, Shigenari Hirokawa
  • NOVEL TRITERPENIC ACID DERIVATIVE AND PREPARATION FOR EXTERNAL APPLICATION FOR SKIN COMPRISING THE SAME
    Publication number: 20090075946
    Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.
    Type: Application
    Filed: April 13, 2006
    Publication date: March 19, 2009
    Applicant: Pola Chemical Industries Inc.
    Inventors: Michio Ochiai, Kenichi Goto, Yoshihiro Tokudome, Shigenari Hirokawa
  • Compositions for electroporation
    Patent number: 7197359
    Abstract: The present invention relates to compositions for electroporation which are useful in elevating percutaneous absorbability of drugs, etc. By controlling electrolyte concentration of compositions for electroporation so as to make an osmotic pressure of the compositions not more than a physical osmotic pressure, the percutaneous absorbability of drugs can be elevated.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: March 27, 2007
    Assignee: Pola Chemical Industries Inc.
    Inventors: Yoshihiro Tokudome, Koji Owaku, Kenichi Goto, Kenji Sugibayashi
  • Compositions for drug administration by electroporation
    Patent number: 7089053
    Abstract: The present invention relates to compositions for electroporation which are useful in elevating a percutaneous absorbability of drugs, etc. By adding polyhydric alcohols to compositions for electroporation, the percutaneous absorbability of drugs is elevated.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: August 8, 2006
    Assignee: Pola Chemical Industries Inc
    Inventors: Yoshihiro Tokudome, Koji Owaku, Kenichi Goto, Kenji Sugibayashi
  • Composition for use in electroporation
    Patent number: 6878548
    Abstract: The present invention is a composition for percutaneous administration suitable for electroporation. Percutaneous absorption of a drug and so forth in a composition for electroporation can be promoted by adding alkaline earth metal ions to the composition.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: April 12, 2005
    Assignee: Pola Chemical Industries Inc.
    Inventors: Yoshihiro Tokudome, Toshihiro Hinokitani, Kenichi Goto, Kenji Sugibayashi, Koji Owaku, Yasunori Inaoka
  • Composition for use in electroporation
    Publication number: 20040071763
    Abstract: The present invention is a composition for percutaneous administration suitable for electroporation. Percutaneous absorption of a drug and so forth in a composition for electroporation can be promoted by adding alkaline earth metal ions to the composition.
    Type: Application
    Filed: August 13, 2003
    Publication date: April 15, 2004
    Inventors: Yoshihiro Tokudome, Toshihiro Hinokitani, Kenichi Goto, Kenji Sugibayashi, Koji Owaku, Yasunori Inaoka
  • Percutaneous absorption promoters for electroporation
    Patent number: 6721595
    Abstract: The present invention relates to percutaneous sorbefacients for electroporation consisting of monoterpene and being useful in elevating percutaneous absorbability of drugs, etc. By adding these percutaneous sorbefacients to compositions for electroporation, the percutaneous absorbability of drugs can be elevated.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: April 13, 2004
    Assignee: Pola Chemical Industries Inc.
    Inventors: Yoshihiro Tokudome, Koji Owaku, Kenichi Goto, Kenji Sugibayashi
  • Method of making valve sleeves
    Patent number: 4689864
    Abstract: A method of making valve sleeves used for controlling the flow of hydraulic fluid in devices, such as power steering units in motorized vehicle, and the product of the utilized method. The method utilizes a grooving male die which forms a groove on an interior surface of a valve sleeve.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: September 1, 1987
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Nobuo Fukuma, Hisayasu Hasegawa, Kimimasa Murayama, Kunio Hayashi, Yoshihiro Tokudome