Patents by Inventor Yoshihiro Urade
Yoshihiro Urade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9181183Abstract: The present invention provides a piperidine compound represented by Formula (I) (wherein X1, X2, X2, A, B and N are as defined in the Description); or a salt thereof.Type: GrantFiled: September 6, 2011Date of Patent: November 10, 2015Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Makoto Kitade, Keiko Yamane, Shinichi Aoki, Hiroyoshi Yamanaka
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Patent number: 9062035Abstract: This invention relates to a piperazine compound represented by Formula (I), wherein R1 is c1-6 alkyl; R2 is hydroxy, c1-6 alkyl that may have one or more substituents, —(C?O)—N(R2)(R4), or —(C?O)—OR5; R3 and R4 are the same or different, and each represents hydrogen or c1-6 alkyl that may have one or more substituents, or R3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; R5 is hydrogen or c1-6 alkyl that may have one or more 15 substituents; and n is 1 or 2; or a salt thereof.Type: GrantFiled: January 8, 2014Date of Patent: June 23, 2015Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Makoto Kitade, Kazuhiko Shigeno, Keiko Yamane, Katsunao Tanaka
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Publication number: 20150147418Abstract: An object of the present invention is to provide a sleep quality improving agent which has a sufficient sleep quality improving effect, can exert makes the effect even through oral administration in any dosage form, and has ensured safety to the body. That is, the present invention provides: a sleep quality improving agent which contains a stilbene-based compound and/or an olive extract as an active ingredient, and a sleep quality improving composition which contains the sleep quality improving agent.Type: ApplicationFiled: June 26, 2013Publication date: May 28, 2015Applicant: LION CORPORATIONInventors: Yoshihiro Urade, Ikuko Kamada, Toshio Gokita, Kiwamu Suzuki, Hiroaki Kambayashi, Michiaki Murakoshi
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Patent number: 8865714Abstract: This invention relates to a piperazine compound represented by Formula (I), wherein R1 is C1-6 alkyl; R2 is hydroxy, C1-6 alkyl that may have one or more substituents, —(C?O)—N(R3)(R4), or —(C?O)—OR5; R3 and R4 are the same or different, and each represents hydrogen or C1-6 alkyl that may have one or more substituents, or R3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; R5 is hydrogen or C1-6 alkyl that may have one or more substituents; and n is 1 or 2; or a salt thereof.Type: GrantFiled: March 8, 2010Date of Patent: October 21, 2014Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Makoto Kitade, Kazuhiko Shigeno, Keiko Yamane, Katsunao Tanaka
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Publication number: 20140248383Abstract: An object is to provide a sleep quality improving agent that can sufficiently exert the effect of improving the quality of sleep and ensures safety for the body. A sleep quality improving agent containing, as an effective ingredient, a plant of the Fraxinus genus such as Fraxinus excelsior L., an extract thereof, Larix sibirica extract, dihydroquercetin, dihydrokaempferol, or naringenin, and a sleep quality improving composition containing the sleep quality improving agent are provided.Type: ApplicationFiled: October 9, 2012Publication date: September 4, 2014Applicant: LION CORPORATIONInventors: Yoshihiro Urade, Toshio Gokita, Ikuko Kamada, Kiwamu Suzuki, Michiaki Murakoshi
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Publication number: 20140227318Abstract: An object is to provide a sleep quality improving agent that has a sufficient effect of improving the quality of sleep, can exert the effect regardless of the form of administration, even by oral administration, and ensures safety for the body. A sleep quality improving agent containing an S-adenosylmethionine-containing yeast as an effective ingredient and a sleep quality improving composition containing the sleep quality improving agent are provided.Type: ApplicationFiled: October 9, 2012Publication date: August 14, 2014Applicant: LION CORPORATIONInventors: Yoshihiro Urade, Toshio Gokita, Ikuko Kamada, Kiwamu Suzuki, Michiaki Murakoshi
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Patent number: 8765750Abstract: The present invention provides a piperazine compound represented by Formula (I) or a salt thereof, wherein X represents CH or an N atom; R1 represents C1-6 alkyl; R2 represents C1-6 alkyl that may have one or more substituents, C2-6 alkenyl that may have one or more substituents, —(C?O)—N(R3)(R4), or —(C?O)—OR5, R3 and R4 are the same or different, and each represents hydrogen or C1-6 alkyl that may have one or more substituents; or R3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; and R5 represents hydrogen or C1-6 alkyl that may have one or more substituents or aralkyl.Type: GrantFiled: January 19, 2011Date of Patent: July 1, 2014Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Makoto Kitade, Kazuhiko Shigeno, Keiko Yamane, Katsunao Tanaka
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Publication number: 20140128394Abstract: This invention relates to a piperazine compound represented by Formula (I), wherein R1 is c1-6 alkyl; R2 is hydroxy, c1-6 alkyl that may have one or more substituents, —(C=0)-N(R2)(R4), or —(C=0)-0R5; R3 and R4 are the same or different, and each represents hydrogen or c1-6 alkyl that may have one or more substituents, or R3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; R5 is hydrogen or c1-6 alkyl that may have one or more 15 substituents; and n is 1 or 2; or a salt thereof.Type: ApplicationFiled: January 8, 2014Publication date: May 8, 2014Applicant: TAIHO PHARMACEUTICAL CO., LTD.Inventors: Yoshihiro URADE, Makoto KITADE, Kazuhiko SHIGENO, Keiko YAMANE, Katsunao TANAKA
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Patent number: 8658390Abstract: Muscle degenerative diseases can be detected in the early stage and the therapeutic efficacy of a therapeutic agent and/or a therapy method for the diseases can be determined by measuring 11,15-dioxo-9?-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (referred to as “Tetranor-PGDM”, hereinbelow) in a sample isolated from a subject.Type: GrantFiled: March 8, 2010Date of Patent: February 25, 2014Assignees: Osaka Bioscience Institute, National Center of Neurology and Psychiatry, Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Kosuke Aritake, Toshihiko Maruyama, Shinya Kamauchi, Shin'ichi Takeda, Akinori Nakamura
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Patent number: 8568967Abstract: A method is provided for diagnosis of the severity of a condition in an eosinophilic inflammatory disease such as nasal polyp and for prediction of the recurrence of the disease.Type: GrantFiled: May 17, 2006Date of Patent: October 29, 2013Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Naomi Eguchi, Kosuke Aritake, Sawako Hyo, Hiroshi Takenaka, Ryo Kawata
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Publication number: 20130165438Abstract: The present invention provides a piperidine compound represented by Formula (I) (wherein X1, X2, X2, A, B and N are as defined in the Description); or a salt thereof.Type: ApplicationFiled: September 6, 2011Publication date: June 27, 2013Applicant: TAIHO PHARMACEUTICAL CO., LTD.Inventors: Yoshihiro Urade, Makoto Kitade, Keiko Yamane, Shinichi Aoki, Hiroyoshi Yamanaka
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Publication number: 20120309760Abstract: The present invention provides a piperazine compound represented by Formula (I) or a salt thereof, wherein X represents CH or an N atom; R1 represents C1-6 alkyl; R2 represents C1-6 alkyl that may have one or more substituents, C2-6 alkenyl that may have one or more substituents, —(C?O)—N(R3)(R4), or —(C?O)—OR5, R3 and R4 are the same or different, and each represents hydrogen or C1-6 alkyl that may have one or more substituents; or R3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; and R5 represents hydrogen or C1-6 alkyl that may have one or more substituents or aralkyl.Type: ApplicationFiled: January 19, 2011Publication date: December 6, 2012Applicant: Taiho Pharmaceutical Co., Ltd.Inventors: Yoshihiro Urade, Makoto Kitade, Kazuhiko Shigeno, Keiko Yamane, Katsunao Tanaka
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Publication number: 20110319413Abstract: This invention relates to a piperazine compound represented by Formula (I), wherein R1 is C1-6 alkyl; R2 is hydroxy, C1-6 alkyl that may have one or more substituents, —(C?O)—N(R3)(R4), or —(C?O)—OR5; R3 and R4 are the same or different, and each represents hydrogen or C1-6 alkyl that may have one or more substituents, or R3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; R5 is hydrogen or C1-6 alkyl that may have one or more substituents; and n is 1 or 2; or a salt thereof.Type: ApplicationFiled: March 8, 2010Publication date: December 29, 2011Applicant: TAIHO PHARMACEUTICAL CO., LTD.Inventors: Yoshihiro Urade, Makoto Kitade, Kazuhiko Shigeno, Keiko Yamane, Katsunao Tanaka
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Publication number: 20110318764Abstract: Muscle degenerative diseases can be detected in the early stage and the therapeutic efficacy of a therapeutic agent and/or a therapy method for the diseases can be determined by measuring 11,15-dioxo-9?-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (referred to as “Tetranor-PGDM”, hereinbelow) in a sample isolated from a subject.Type: ApplicationFiled: March 8, 2010Publication date: December 29, 2011Applicants: OSAKA BIOSCIENCE INSTITUTE, TAIHO PHARMACEUTICAL CO., LTD., NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRYInventors: Yoshihiro Urade, Kosuke Aritake, Toshihiko Maruyama, Shinya Kamauchi, Shin'ichi Takeda, Akinori Nakamura
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Patent number: 7951956Abstract: The present invention provides a benzimidazole compound represented by Formula (I) wherein X1 is oxygen or carbonyl, and R1 is a furan ring having 1 to 3 substituents or a pyrrole ring that may have 1 to 3 substituents; excluding compounds represented by Formula (I) wherein at least one of the substituents is a phosphoric acid group or a phosphoric ester group; or a salt thereof. The benzimidazole compound or salt thereof has excellent prostaglandin synthase inhibitory activity, and is useful as an agent for preventing and/or treating diseases in which prostaglandin D2 or metabolites thereof participates, such as allergic and inflammatory diseases, and as inhibitor for the exacerbation of Alzheimer's disease or cerebral damage.Type: GrantFiled: July 12, 2006Date of Patent: May 31, 2011Assignee: Taiho Pharmaceuticals Co., Ltd.Inventors: Yoshihiro Urade, Yoshiki Tanaka, Keiko Yamane, Michinori Togawa
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Publication number: 20100286415Abstract: The invention provides a sleep-improving agent and a sedative agent containing, as an active ingredient, oxypinnatanine or its derivative represented by the following chemical formula (I):Type: ApplicationFiled: May 29, 2008Publication date: November 11, 2010Applicants: OSAKA BIOSCIENCE INSTITUTE, THE DOSHISHA, KUREI OKINAWA CO., LTD.Inventors: Yoshihiro Urade, Zhi-Li Huang, Masashi Wada, Nahoko Uchiyama, Tenji Konishi, Norio Nakamura
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Publication number: 20100138937Abstract: A method for diagnosis of the severity of a condition in an eosinophilic inflammatory disease such as nasal polyp or for prediction of the recurrence of the disease, the method comprising detecting H-PGDS induced by eosinophilic leukocytes accumulated in a lesion or determining pGD2 in a nasal alveolar lavage fluid or Bronchoalveolar lavage fluidType: ApplicationFiled: May 17, 2006Publication date: June 3, 2010Inventors: Yoshihiro Urade, Naomi Eguchi, Kosuke Aritake, Sawako Hyo, Hiroshi Takenaka, Ryo Kawata
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Publication number: 20090281098Abstract: The present invention provides a benzimidazole compound represented by Formula (I) wherein X1 is oxygen or carbonyl, and R1 is a furan ring having 1 to 3 substituents or a pyrrole ring that may have 1 to 3 substituents; excluding compounds represented by Formula (I) wherein at least one of the substituents is a phosphoric acid group or a phosphoric ester group; or a salt thereof. The benzimidazole compound or salt thereof has excellent prostaglandin synthase inhibitory activity, and is useful as an agent for preventing and/or treating diseases in which prostaglandin D2 or metabolites thereof participates, such as allergic and inflammatory diseases, and as inhibitor for the exacerbation of Alzheimer's disease or cerebral damage.Type: ApplicationFiled: July 12, 2006Publication date: November 12, 2009Applicant: TAIHO PHARMACEUTICAL CO., LTD.Inventors: Yoshihiro Urade, Yoshiki Tanaka, Keiko Yamane, Michinori Togawa
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Publication number: 20090263784Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.Type: ApplicationFiled: January 30, 2009Publication date: October 22, 2009Inventors: Yoshihiro URADE, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
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Patent number: 7547532Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.Type: GrantFiled: September 27, 2002Date of Patent: June 16, 2009Assignee: Japan Science and Technology AgencyInventors: Yoshihiro Urade, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano