Patents by Inventor Yoshihisa Akiyama
Yoshihisa Akiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160152653Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: ApplicationFiled: December 30, 2015Publication date: June 2, 2016Inventors: Yoshihiko KOBAYASHI, Yoshihisa AKIYAMA, Takeshi MURAKAMI, Nobuto MINOWA, Masaki TSUSHIMA, Yukiko HIRAIWA, Shoichi MURAKAMI, Mitsuhiro ABE, Kazushige SASAKI, Shigeru HOSHIKO, Toshiaki MIYAKE, Yoshiaki TAKAHASHI, Daishiro IKEDA
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Patent number: 9260465Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: GrantFiled: August 20, 2013Date of Patent: February 16, 2016Assignees: MEIJI SEIKA PHARMA CO., LTD., MICROBIAL CHEMISTRY RESEARCH FOUNDATIONInventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20130345411Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: ApplicationFiled: August 20, 2013Publication date: December 26, 2013Applicants: MICROBIAL CHEMISTRY RESEARCH FOUNDATION, MEIJI SEIKA PHARMA CO., LTD.Inventors: Yoshihiko KOBAYASHI, Yoshihisa AKIYAMA, Takeshi MURAKAMI, Nobuto MINOWA, Masaki TSUSHIMA, Yukiko HIRAIWA, Shoichi MURAKAMI, Mitsuhiro ABE, Kazushige SASAKI, Shigeru HOSHIKO, Toshiaki MIYAKE, Yoshiaki TAKAHASHI, Daishiro IKEDA
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Patent number: 8541394Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: GrantFiled: March 7, 2012Date of Patent: September 24, 2013Assignees: Meiji Seika Pharma Co., Ltd., Microbial Chemistry Research FoundationInventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20120165283Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: ApplicationFiled: March 7, 2012Publication date: June 28, 2012Inventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Patent number: 8148504Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: GrantFiled: June 1, 2007Date of Patent: April 3, 2012Assignees: Meiji Seika Pharma Co., Ltd., Microbial Chemistry Research FoundationInventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20090186841Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: ApplicationFiled: June 1, 2007Publication date: July 23, 2009Inventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20070161581Abstract: Disclosed are compounds represented by general formula (I) or pharmacologically acceptable salts or solvates thereof having excellent antimicrobial activity against bacteria causative of severe infections such as pneumonia and septicemia, particularly against MRSA, and also antimicrobial agents comprising these compounds, and pharmaceutical compositions comprising these compounds as an active component.Type: ApplicationFiled: January 21, 2005Publication date: July 12, 2007Inventors: Nobuto Minowa, Takayuki Usui, Yoshihisa Akiyama, Hirawa Yukiko, Toshio Yoneta, Toshifumi Hasegawa, Kazunori Maebashi, Takashi Ida, Kazuko Katsumata, Keiko Otsuka, Daishiro Ikeda
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Patent number: 6677331Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1.Type: GrantFiled: August 14, 2002Date of Patent: January 13, 2004Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yuko Kano, Toshiro Sasaki, Yumiko Sambongi, Kiyoshi Tanabe, Yoshihisa Akiyama, Hideo Kitagawa, Takahisa Maruyama, Hiromasa Takizawa, Takashi Ando, Kazuhiro Aihara, Kunio Atsumi, Katsuyoshi Iwamatsu, Takashi Ida
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Publication number: 20030149016Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the, carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1.Type: ApplicationFiled: August 14, 2002Publication date: August 7, 2003Inventors: Yuko Kano, Toshiro Sasaki, Yumiko Sambongi, Kiyoshi Tanabe, Yoshihisa Akiyama, Hideo Kitagawa, Takahisa Maruyama, Hiromasa Takizawa, Takashi Ando, Kazuhiro Aihara, Kunio Atsumi, Katsuyoshi Iwamatsu, Takashi Ida
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Patent number: 6458780Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1.Type: GrantFiled: January 26, 2001Date of Patent: October 1, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yuko Kano, Toshiro Sasaki, Yumiko Sambongi, Kiyoshi Tanabe, Yoshihisa Akiyama, Hideo Kitagawa, Takahisa Maruyama, Hiromasa Takizawa, Takashi Ando, Kazuhiro Aihara, Kunio Atsumi, Katsuyoshi Iwamatsu, Takashi Ida
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Patent number: 4870744Abstract: In a tool exchange system, in which the selection of a tool (8) supported on a magazine (9) is done by the rotation of a main spindle (5) via a pair of gears (20) and (21), an elastic member (71) is provided so as to retain the magazine (9) in a machining position (pause position) which does not interfere with a machining operation. A first cam mechanism (11) is adapted to move the magazine (9) between a tool exchange position and the machining position in response to the vertical move of a Z-slider (3) moving along a column (1). A second cam mechanism (12) is adapted to operate a tool attachment/removal means (6).Type: GrantFiled: June 16, 1988Date of Patent: October 3, 1989Assignee: Fanuc Ltd.Inventors: Hiroshi Araki, Hisao Ishii, Yoshihisa Akiyama, Hiroshi Kamada, Takashi Nagatomi
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Patent number: 4745673Abstract: A spindle head unit having a bell crank lever (24) mounted pivotally on a spindle head (10) of a machining center to depress a drawbar (18) inserted through a spindle (14) mounted on the spindle head (10). One of arms of the bell crank lever (24) is located so as to be capable of being engaged with a guide cam (28) and a depressing end (24a) in the shape of a spherical protrusion which is not connected mechanically to an upper end (18a) of the drawbar (18) is formed in a free end of the other arm of the bell crank lever (24). The bell crank lever (24) is urged continuously by a spring means (32) so that the former arm is urged toward the guide cam (28).Type: GrantFiled: August 12, 1987Date of Patent: May 24, 1988Assignee: Fanuc Ltd.Inventors: Hiroshi Araki, Toshiyuki Aso, Yoshihisa Akiyama