Patents by Inventor Yoshiji Yamada
Yoshiji Yamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7745137Abstract: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.Type: GrantFiled: March 6, 2009Date of Patent: June 29, 2010Assignee: Nagoya Industrial Science Research InstituteInventors: Yoshiji Yamada, Mitsuhiro Yokota
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Patent number: 7645572Abstract: It is intended to provide a means of diagnosing genetic risk of restenosis after coronary angioplasty which shows a high accuracy and a high estimation ratio. The risk of restenosis after coronary angioplasty is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 6 gene polymorphisms proved as relating to restenosis after balloon expansion or 5 gene polymorphisms proved as relating to restenosis after stent insertion; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of restenosis after coronary angioplasty form the genotype thus determined.Type: GrantFiled: March 20, 2003Date of Patent: January 12, 2010Assignee: Nagoya Industrial Science Research InstituteInventors: Yoshiji Yamada, Mitsuhiro Yokota
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Publication number: 20090239227Abstract: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.Type: ApplicationFiled: March 6, 2009Publication date: September 24, 2009Applicant: Nagoya Industrial Science Research InstituteInventors: Yoshiji Yamada, Mitsuhiro Yokota
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Patent number: 7572576Abstract: It is intended to provide a means of predicting genetic risk for hypertension at a high accuracy and high prediction possibility. Namely, risk for hypertension is predicted by a method involving the following steps: (i) the step of analyzing two or more polymorphisms selected from among 4 gene polymorphisms having been revealed as relating to hypertension; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of predicting the genetic risk for hypertension from the genotype thus determined.Type: GrantFiled: September 22, 2003Date of Patent: August 11, 2009Assignee: Nagoya Industrial Science Research InstituteInventors: Yoshiji Yamada, Mitsuhiro Yokota
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Patent number: 7521181Abstract: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.Type: GrantFiled: March 20, 2003Date of Patent: April 21, 2009Assignee: Nagoya Industrial Science Research InstituteInventors: Yoshiji Yamada, Mitsuhiro Yokota
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Publication number: 20060099590Abstract: It is intended to provide a means of diagnosing genetic risk of restenosis after coronary angioplasty which shows a high accuracy and a high estimation ratio. The risk of restenosis after coronary angioplasty is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 6 gene polymorphisms proved as relating to restenosis after balloon expansion or 5 gene polymorphisms proved as relating to restenosis after stent insertion; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of restenosis after coronary angioplasty form the genotype thus determined.Type: ApplicationFiled: March 20, 2003Publication date: May 11, 2006Inventors: Yoshiji Yamada, Mitsuhiro Yokota
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Publication number: 20060099594Abstract: It is intended to provide a means of predicting genetic risk for hypertension at a high accuracy and high prediction possibility. Namely, risk for hypertension is predicted by a method involving the following steps: (i) the step of analyzing two or more polymorphisms selected from among 4 gene polymorphisms having been revealed as relating to hypertension; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of predicting the genetic risk for hypertension from the genotype thus determined.Type: ApplicationFiled: September 22, 2003Publication date: May 11, 2006Applicant: NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTEInventors: Yoshiji Yamada, Mitsuhiro Yokota
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Patent number: 6998242Abstract: A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. Monoclonal antibodies recognizing equally both of monomer type and dimer type of OCIF. Monoclonal antibodies recognizing selectively dimer type of OCIF. And to provide an assay kit for determination of OCIF concentration comprising the aforementioned two antibodies recognizing different epitope of OCIF and having high affinity showing dissociation constant of less than 2×10?7 M with antigen. It is useful for a method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis or for an assay reagent for research thereof.Type: GrantFiled: August 15, 2003Date of Patent: February 14, 2006Assignee: Sankyo Co., Ltd.Inventors: Kazuki Yano, Fumie Kobayashi, Masaaki Goto, Naohiro Washida, Eisuke Tsuda, Kaoji Higashio, Yoshiji Yamada
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Publication number: 20050260124Abstract: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.Type: ApplicationFiled: March 20, 2003Publication date: November 24, 2005Inventors: Yoshiji Yamada, Mitsuhiro Yokota
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Publication number: 20040033533Abstract: A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. Monoclonal antibodies recognizing equally both of monomer type and dimer type of OCIF. Monoclonal antibodies recognizing selectively dimer type of OCIF. And to provide an assay kit for determination of OCIF concentration comprising the aforementioned two antibodies recognizing different epitope of OCIF and having high affinity showing dissociation constant of less than 2×10−7 M with antigen. It is useful for a method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis or for an assay reagent for research thereof.Type: ApplicationFiled: August 15, 2003Publication date: February 19, 2004Inventors: Kazuki Yano, Fumie Kobayashi, Masaaki Goto, Naohiro Washida, Eisuke Tsuda, Kaoji Higashio, Yoshiji Yamada
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Patent number: 6693175Abstract: A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. Monoclonal antibodies recognizing equally both of monomer type and dimer type of OCIF. Monoclonal antibodies recognizing selectively dimer type of OCIF. And to provide an assay kit for determination of OCIF concentration comprising the aforementioned two antibodies recognizing different epitope of OCIF and having high affinity showing dissociation constant of less than 2×10−7 M with antigen. It is useful for a method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis or for an assay reagent for research thereof.Type: GrantFiled: May 24, 1999Date of Patent: February 17, 2004Assignee: Sankyo Co., Ltd.Inventors: Kazuki Yano, Fumie Kobayashi, Masaaki Goto, Naohiro Washida, Eisuke Tsuda, Kanji Higashio, Yoshiji Yamada
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Publication number: 20020004207Abstract: A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor.Type: ApplicationFiled: May 24, 1999Publication date: January 10, 2002Inventors: KAZUKI YANO, FUMIE KOBAYASHI, MASAAKI GOTO, NAOHIRO WASHIDA, EISUKE TSUDA, KANJI HIGASHIO, YOSHIJI YAMADA
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Patent number: 4827795Abstract: A connecting rod having a pair of spaced apart flanges parallel to a plane defined by a crankshaft axis and a piston pin axis. A web connects the flanges to form a rod portion having an I-shaped cross section. The inner surfaces of the flanges include a lateral rounded projection adjacent to the flange edges to improve bending and stress characteristics.Type: GrantFiled: September 27, 1988Date of Patent: May 9, 1989Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Isao Machida, Yasunori Sato, Yoshiji Yamada