Abstract: A medicament for therapeutic treatment and/or improvement of sepsis in a patient with severe sepsis accompanied with one or more organ dysfunctions, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4, which comprises thrombomodulin as an active ingredient.

Abstract: A medicament for therapeutic treatment and/or improvement of sepsis in a patient with severe sepsis accompanied with one or more organ dysfunctions, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4, which comprises thrombomodulin as an active ingredient.

Abstract: A method for producing an oxidized cyclic phenol sulfide which comprises the step of oxidizing a cyclic phenol sulfide of the following formula (1) as a raw material: wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, and m is an integer from 4 to 8, in a solvent(s) other than a halogenated hydrocarbon in an amount of 2 or more and less than 10 parts by weight per 1 part by weight of the cyclic phenol sulfide, with an oxidizing agent(s) to obtain an oxidized cyclic phenol sulfide of the following formula (2): wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 8, and n is 1 or 2.

Abstract: The object of the present invention is, in methods for producing cyclic phenol sulfides, to provide methods for producing a number of more macrocyclic products, which comprise the steps of producing a mixture of cyclic phenol sulfides from an inexpensive raw material in one step without inducing the reduction in yield of a cyclic quatromer; and easily separating and purifying a single component from the mixture of cyclic phenol sulfides. The present invention discloses methods for producing a cyclic phenol sulfide which comprises the step of reacting a phenol compound as a raw material, in a one-step reaction, with 1.7 to 2.5 molar equivalent of sulfur and 0.25 to 0.75 molar equivalent of an alkali metal reagent per 1 mol of the phenol compound to obtain a mixture of cyclic phenol sulfide wherein m=4 and at least one kind(s) of cyclic phenol sulfide wherein m=5 to 9, or each separate cyclic phenol sulfide comprised in the mixture.

Abstract: A method for producing an oxidized cyclic phenol sulfide which comprises the step of oxidizing a cyclic phenol sulfide of the following formula (1) as a raw material: wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, and m is an integer from 4 to 8, in a solvent(s) other than a halogenated hydrocarbon in an amount of 2 or more and less than 10 parts by weight per 1 part by weight of the cyclic phenol sulfide, with an oxidizing agent(s) to obtain an oxidized cyclic phenol sulfide of the following formula (2): wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 8, and n is 1 or 2.

Abstract: The present invention discloses a method for continuously producing an oxidized cyclic phenol sulfide which comprises the continuous steps of reacting a para-alkyl phenol compound as a raw material with 1.7 to 2.5 molar equivalent of sulfur and 0.25 to 0.75 molar equivalent of an alkali metal reagent per 1 mol of the phenol compound (the first step); and oxidizing a cyclic phenol sulfide of the formula (2) produced by the above reaction with an oxidizing agent(s) in the same reactor as that of the first step and without taking the cyclic phenol sulfide out of the reactor: wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, and m is an integer from 4 to 8, to obtain an oxidized cyclic phenol sulfide of the formula (3) (the second step): wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 8, and n is 1 or 2.

Abstract: The present invention provides a process for producing N,N?-carbonyldiimidazole, comprising: reacting phosgene, diphosgene, or triphosgene with imidazole in an inert solvent to produce N,N?-carbonyldiimidazole; to imidazole hydrochloride yielded as a by-product in the above step, adding a gaseous or liquid basic compound represented by the below-shown general formula (1) in an inert solvent to conduct neutralization reaction; and circulating the imidazole thus generated to use it as a starting material for N,N?-carbonyldiimidazole production. In the general formula (1), R1, R2, and R3 each independently represents a hydrogen atom, a methyl group, or an ethyl group. The CDI produced by the production process of the invention is a compound useful in the fields of synthesis of pharmaceutical agents, synthesis of agricultural chemicals, peptide synthesis, and the like, e.g.

Abstract: The present invention discloses a mixed cyclic phenol sulfide which is a mixture of the cyclic phenol sulfide wherein m is 8 and the cyclic phenol sulfide wherein m is an integer other than 8, the cyclic phenol sulfide being represented by the following formula (1): wherein R is a straight or branched alkyl group having 1 to 6 carbon atoms, and m is an integer from 4 to 9; or a cyclic phenol sulfide of formula (1) wherein m is 8. The present invention also discloses a charge control agent which comprises the above sulfide(s) as the active ingredient; and a toner which comprises the charge control agent, a coloring agent and a binder resin. This charge control agent is particularly useful for color toners, and it speeds up charging risetime, and has a high charge amount and charging characteristics excellent in the environmental stability. Further, the charge control agent is safe since it does not have any problem with the waste regulations.

Abstract: The present invention discloses a charge control agent which comprises a metal compound of a cyclic phenol sulfide of the following formula (1) as an active ingredient: wherein at least one of several Y is a metal atom. The present invention also discloses a toner which comprises one or more kinds of said metal compound, a coloring agent and a binder resin. The charge control agent of the present invention overcomes disadvantages such as lack of sharpness of first copied images and instability of the quality of the copied images in continuously copying, and it is those applicable to recent high speed printers, which have a quick charging rise time, an excellent environmental stability since the charge amount thereof less varies depending on the changes of temperature and humidity, and a high frictional charge amount. In addition, by using said charge control agent, a toner having a negative electric with high charging performance can be provided.

Abstract: The present invention discloses a method for continuously producing an oxidized cyclic phenol sulfide which comprises the continuous steps of reacting a para-alkyl phenol compound as a raw material with 1.7 to 2.5 molar equivalent of sulfur and 0.25 to 0.75 molar equivalent of an alkali metal reagent per 1 mol of the phenol compound (the first step); and oxidizing a cyclic phenol sulfide of the formula (2) produced by the above reaction with an oxidizing agent(s) in the same reactor as that of the first step and without taking the cyclic phenol sulfide out of the reactor; wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, and m is an integer from 4 to 8, to obtain an oxidized cyclic phenol sulfide of the formula (3) (the second step): wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 8, and n is 1 or 2.

Abstract: A developing device has a developer bearing member, a housing adapted to accommodate a developer, and a supply roller adapted to supply the developer within the housing for the developer bearing member. The supply roller has an outer circumferencial foam layer made of resin or rubber. The foam layer has an air permeability of 150-200 ml/cm2/s, a hardness of 50-200 N, and an average cell density of 20-40 per 25 mm width.

Abstract: The present invention discloses an oxidized mixed cyclic phenol sulfide which is a mixture of the oxidized cyclic phenol sulfide wherein m is 8 and the oxidized cyclic phenol sulfide wherein m is an integer other than 8, the oxidized cyclic phenol sulfide being represented by the following formula (1): wherein R is a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 9, and n is 1 or 2; or an oxidized cyclic phenol sulfide of formula (1) wherein m is 8. The present invention also discloses a charge control agent which comprises the above sulfide(s) as the active ingredient; and a toner which comprises the charge control agent, a coloring agent and a binder resin. This charge control agent is particularly useful for color toners, and it speeds up charging risetime, and has a high charge amount and charging characteristics excellent in environmental stability. Further, the charge control agent is safe since it does not have any problem with the waste regulations.

Abstract: It is an object of the present invention to provide a therapeutically effective agent for therapy and/or improvement of DIC, or a method for treating and/or improving DIC. The present invention provides an agent for therapy and/or improvement of disseminated intravascular coagulation comprising thrombomodulin as an active ingredient, which is administered to antithrombin-reduced patients having a low plasma antithrombin activity of less than 50%.

Abstract: A multiplexer according to an embodiment of the present invention multiplexes a video ES and an audio ES to generate a transport stream TS, and includes a video buffer, an audio buffer, and a multiplexing unit. A multiplexing unit executes simulation of a buffer occupation necessary for a video ES upon decoding the TS, and controls multiplexing of the video ES not to cause overflow of a buffer based on the simulation result. In the simulation, a predetermined time ?t is divided by N ((main buffer leak rate/system clock frequency)×N (N is an integer)=integer), the remainder R is carried over to the next calculation, and a current main buffer leak data amount is calculated by integer arithmetic based on the integral quotient.

Abstract: The present invention discloses an oxidized mixed cyclic phenol sulfide which is a mixture of the oxidized cyclic phenol sulfide wherein m is 8 and the oxidized cyclic phenol sulfide wherein m is an integer other than 8, the oxidized cyclic phenol sulfide being represented by the following formula (1): wherein R is a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 9, and n is 1 or 2; or an oxidized cyclic phenol sulfide of formula (1) wherein m is 8. The present invention also discloses a charge control agent which comprises the above sulfide(s) as the active ingredient; and a toner which comprises the charge control agent, a coloring agent and a binder resin. This charge control agent is particularly useful for color toners, and it speeds up charging risetime, and has a high charge amount and charging characteristics excellent in environmental stability. Further, the charge control agent is safe since it does not have any problem with the waste regulations.

Abstract: An image forming apparatus has an electrostatic latent image bearing member capable of bearing an electrostatic latent image thereon, and a developer apparatus having a developer material for visualizing the electrostatic latent image into a visualized image. The developer apparatus includes a developer material bearing member, a housing adapted to accommodate a developer material, and a supply roller adapted to supply the developer material within the housing for the developer material bearing member. The supply roller has an outer circumferential foam layer. The foam layer is made of resin foam or rubber foam and has an air permeability of 5 ml/cm2/s or less, a density of 50-200 kg/m3, and a hysteresis loss ratio of 35-45%.

Abstract: A method for producing an oxidized cyclic phenol sulfide which comprises the step of oxidizing a cyclic phenol sulfide of the following formula (1) as a raw material: wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, and m is an integer from 4 to 8, in a solvent(s) other than a halogenated hydrocarbon in an amount of 2 or more and less than 10 parts by weight per 1 part by weight of the cyclic phenol sulfide, with an oxidizing agent(s) to obtain an oxidized cyclic phenol sulfide of the following formula (2): wherein R represents a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 8, and n is 1 or 2.

Abstract: The object of the present invention is, in methods for producing cyclic phenol sulfides, to provide methods for producing a number of more macrocyclic products, which comprise the steps of producing a mixture of cyclic phenol sulfides from an inexpensive raw material in one step without inducing the reduction in yield of a cyclic quatromer; and easily separating and purifying a single component from the mixture of cyclic phenol sulfides. The present invention discloses methods for producing a cyclic phenol sulfide which comprises the step of reacting a phenol compound as a raw material, in a one-step reaction, with 1.7 to 2.5 molar equivalent of sulfur and 0.25 to 0.75 molar equivalent of an alkali metal reagent per 1 mol of the phenol compound to obtain a mixture of cyclic phenol sulfide wherein m=4 and at least one kind(s) of cyclic phenol sulfide wherein m=5 to 9, or each separate cyclic phenol sulfide comprised in the mixture.

Abstract: The present invention discloses an oxidized mixed cyclic phenol sulfide which is a mixture of the oxidized cyclic phenol sulfide wherein m is 8 and the oxidized cyclic phenol sulfide wherein m is an integer other than 8, the oxidized cyclic phenol sulfide being represented by the following formula (1): wherein R is a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 9, and n is 1 or 2; or an oxidized cyclic phenol sulfide of formula (1) wherein m is 8. The present invention also discloses a charge control agent which comprises the above sulfide(s) as the active ingredient; and a toner which comprises the charge control agent, a coloring agent and a binder resin. This charge control agent is particularly useful for color toners, and it speeds up charging risetime, and has a high charge amount and charging characteristics excellent in environmental stability. Further, the charge control agent is safe since it does not have any problem with the waste regulations.

Abstract: The present invention provides a process for producing N,N?-carbonyldiimidazole, comprising: reacting phosgene, diphosgene, or triphosgene with imidazole in an inert solvent to produce N,N?-carbonyldiimidazole; to imidazole hydrochloride yielded as a by-product in the above step, adding a gaseous or liquid basic compound represented by the below-shown general formula (1) in an inert solvent to conduct neutralization reaction; and circulating the imidazole thus generated to use it as a starting material for N,N?-carbonyldiimidazole production. In the general formula (1), R1, R2, and R3 each independently represents a hydrogen atom, a methyl group, or an ethyl group. The CDI produced by the production process of the invention is a compound useful in the fields of synthesis of pharmaceutical agents, synthesis of agricultural chemicals, peptide synthesis, and the like, e.g.